Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Chemicals and Drugs (2)
- Other Chemicals and Drugs (2)
- Bacteria (1)
- Bacterial Infections and Mycoses (1)
- Bioethics and Medical Ethics (1)
-
- Chemistry (1)
- Community Health and Preventive Medicine (1)
- Diseases (1)
- Genetics and Genomics (1)
- Health and Medical Administration (1)
- Immunology and Infectious Disease (1)
- Infectious Disease (1)
- International Public Health (1)
- Life Sciences (1)
- Medical Microbiology (1)
- Medical Sciences (1)
- Medical Specialties (1)
- Medicinal-Pharmaceutical Chemistry (1)
- Microbiology (1)
- Organisms (1)
- Pharmacology, Toxicology and Environmental Health (1)
- Physical Sciences and Mathematics (1)
- Primary Care (1)
- Public Health (1)
- Public Health Education and Promotion (1)
- Skin and Connective Tissue Diseases (1)
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Modern Approaches To Treating Hospital Acquired Infections: An Overview Of Current Treatments Using Antibiotics And New Therapies Centered Around Photo-Activated Porphyrins, Meghan Johns
Senior Honors Theses
Annually, hospital-acquired infections (HAIs) affect hundreds of thousands of people in the U.S. and impose a great economic burden. The current problem is further exacerbated due to the failure of traditional treatment strategies considering the rise in antimicrobial resistance rates. Besides the fact that antimicrobial resistances complicates clinical treatment strategies, patients are also more vulnerable to secondary infections and complications from prolonged antibiotic use. As a result, research investigating novel treatment strategies for bacterial infections has recently increased. A strategy using porphyrin-based compounds is showing promise. Porphyrins and their derivatives have exhibited bactericidal effects against Gram-positive bacteria by the destruction …
Infections Not Fought: Antibiotic Resistance In Underserved Communities, Derek Lillestolen
Infections Not Fought: Antibiotic Resistance In Underserved Communities, Derek Lillestolen
Senior Honors Theses
In 1928, the profound effects of penicillin were discovered and antibiotic treatments became extremely popular. Broad-spectrum antibiotics, like tetracyclines, have been since branded as cure-all prescriptions and used profusely in the Western World and abroad. Due to ignorance of specific biochemical mechanisms and the misuse of antibiotics these drugs inadvertently allowed the rise in prevalence of antibiotic resistant strains of certain bacteria as the century progressed. Now, the specific genetic causes and mechanisms of antibiotic resistance are being understood, but the fight against antimicrobial resistance is far from over. In the United States, thousands of fatalities are caused annually by …
Antibiotic Overuse: The History, Consequences, And Possible Solutions, Brooke A. Bost
Antibiotic Overuse: The History, Consequences, And Possible Solutions, Brooke A. Bost
Senior Honors Theses
Antibiotic overuse has become alarmingly accepted in the developed world. This overuse is leading to drug resistance in microbes, resulting in bacterial infections that are impossible to treat. Steps must be taken to reverse the damage that has already been done and prevent further resistance from developing. This thesis will examine the context and societal situations that led to this acceptance of antibiotic overuse and misuse seen in both health care professionals and the public, the biochemical and genetic pathways that allow a microbe to develop drug resistance, the various methods that have been suggested by experts to prevent and …
Current Antibiotics And Future Herbal Extract Methods To Treat Methicillin-Resistant Staphylococcus Aureus (Mrsa): Focusing On Inhibition Of Penicillin-Binding Protein 2a (Pbp2a), Mgayya R. Makullah
Current Antibiotics And Future Herbal Extract Methods To Treat Methicillin-Resistant Staphylococcus Aureus (Mrsa): Focusing On Inhibition Of Penicillin-Binding Protein 2a (Pbp2a), Mgayya R. Makullah
Senior Honors Theses
Methicillin-Resistant Staphylococcus aureus (MRSA) has developed resistance towards a number of antibiotics. This resistance creates a challenge when trying to treat MRSA with a number of antibiotics. This is mainly caused by the penicillin-binding proteins 2a (PBP2a). PBP2a have significantly less affinity for beta-lactam antibiotics compared to the other penicillin-binding proteins (PBPs) expressed by non-resistant strains. New treatments involving a combination of antibiotics and herbal extracts are being developed and used to inactivate PBP2a, allowing the previous ineffective antibiotics to be more effective.