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Articles 1 - 15 of 15
Full-Text Articles in Medicine and Health Sciences
Protein Aggregates And Polyglutamine Tracts In Neurodegenerative Disease, John Mack
Protein Aggregates And Polyglutamine Tracts In Neurodegenerative Disease, John Mack
Senior Honors Theses
The incidence of neurodegenerative diseases such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease and other Polyglutamine Diseases is projected to dramatically increase throughout the developed world, and yet the pathology of these diseases remains poorly understood. One pathway that these neurodegenerative diseases share is the accumulation of pathologic proteins which are not only harmful in their soluble form but may go on to form toxic aggregates. In many cases, a consensus has yet to be reached concerning the mechanism for protein aggregation. Therefore, the exploration of the roles of these proteins and their possible mechanisms, along with potential techniques for …
The Advancements Of Feline Renal Allograft Transplantation Techniques And Treatments, Morgan Simon
The Advancements Of Feline Renal Allograft Transplantation Techniques And Treatments, Morgan Simon
Senior Honors Theses
In recent years, kidney transplants have become a viable treatment option for chronic kidney disease in felines. Chronic kidney disease is the leading disease in geriatric cats with 20% of these geriatric cats being affected. Feline kidney transplantation has been met with many different issues regarding ethics, diagnosis, methods, and complications. There are some individuals that believe kidney transplants should not be done in felines because consent from the feline cannot be obtained. The diagnosis of chronic kidney disease has been on the rise in recent years which may be due to new classification standards. There have been many different …
Nursing With The Heart Of Christ, Gwen E. Boda
Nursing With The Heart Of Christ, Gwen E. Boda
Senior Honors Theses
Within the nursing profession it is necessary for the nurse to learn to have love, compassion, joy, peace, patience, humility, and integrity within his/her character. After reviewing numerous peer reviewed journals and personal examples, the following paper reveals how these traits – love, compassion, joy, peace, patience, humility, and integrity – are beneficial within the nursing profession. The paper defines the mentioned characteristics, shows how they can be used and implemented within the nursing practice, demonstrates how their implementation leads to greater patient care, and then compares these traits and actions to the character and person of Christ.
Social Work Trauma Interventions: Dialectical Behavioral Therapy, Kassie Baumann
Social Work Trauma Interventions: Dialectical Behavioral Therapy, Kassie Baumann
Senior Honors Theses
According to Lynne Weilart (2013), in her article on the reasons why people seek out therapy, trauma is the number one reason people attend counseling. Many different trauma-informed approaches are designed specifically to address the consequences of trauma and to facilitate healing. Some of these approaches are as follows: Cognitive Behavioral Therapy (CBT); Dialectical Behavioral Therapy (DBT);Mentalization Based Therapy (MBT); Trauma Systems Therapy (TST); Trauma Assessment Pathway (TAP); and Attachment, Self-Regulation, and Competency (ARC) (de Arellano, Danielson, Ko, & Sprauge, 2008). The effectiveness of each trauma intervention will be examined. DBT is one of these trauma interventions that is growing …
Supplemental Training And Injury Prevention In The Sport Of Ultra-Running, Jessica M. Heidebrink
Supplemental Training And Injury Prevention In The Sport Of Ultra-Running, Jessica M. Heidebrink
Senior Honors Theses
By definition, ultra-marathon running is a sport that covers any distance above the 26.2-mile marathon distance in a single race. The mountains of Virginia host many ultra-marathon races that attract endurance runners from all over the nation to participate. Training is an essential component of running an ultra. Although there is not one specific way to train for an ultra, there is research that correlates the success of the top ultra-runners and their training preferences regarding supplemental training and injury prevention. To gain a more complete understanding of how to prepare for a successful ultra-marathon, an online survey was created …
Spinal Cord Trauma: An Overview Of Normal Structure And Function, Primary And Secondary Mechanisms Of Injury, And Emerging Treatment Modalities, Daniel Morin
Senior Honors Theses
The structures of the spinal cord and vertebral column are designed to provide flexibility, while still providing ample protection for the spinal cord deep within. While it does offer remarkable protection against most routine trauma, the spinal cord is still vulnerable to high-force etiologies of trauma and may become damaged as a result. These events are referred to as primary injury. Following the initial injury, the body’s own physiological responses cause a cascade of deleterious effects, known as secondary injury. Secondary injury is a major therapeutic target in mitigating the effects of spinal cord injury (SCI), and much research is …
The Impact Of Diabetes Mellitus On Burns And Standard Burn Treatments, Emma Shepard
The Impact Of Diabetes Mellitus On Burns And Standard Burn Treatments, Emma Shepard
Senior Honors Theses
Burns are complex injuries that trigger the stress response and result in increased blood glucose. Diabetes mellitus, an endocrine disorder with abnormal glucose regulation, can significantly alter the risk for burns and the treatment of burns. Pre-existing diabetes mellitus complicates burn treatments and healing ability. Diabetes mellitus may also develop directly from an unregulated stress response to the burn. The consideration of diabetes mellitus affects wound care, medications, and nutrition for burn patients. As patient advocates, nurses are responsible for caring for burn patients with awareness of endocrine complications. This paper provides a detailed overview of the pathophysiology, complications, and …
Infections Not Fought: Antibiotic Resistance In Underserved Communities, Derek Lillestolen
Infections Not Fought: Antibiotic Resistance In Underserved Communities, Derek Lillestolen
Senior Honors Theses
In 1928, the profound effects of penicillin were discovered and antibiotic treatments became extremely popular. Broad-spectrum antibiotics, like tetracyclines, have been since branded as cure-all prescriptions and used profusely in the Western World and abroad. Due to ignorance of specific biochemical mechanisms and the misuse of antibiotics these drugs inadvertently allowed the rise in prevalence of antibiotic resistant strains of certain bacteria as the century progressed. Now, the specific genetic causes and mechanisms of antibiotic resistance are being understood, but the fight against antimicrobial resistance is far from over. In the United States, thousands of fatalities are caused annually by …
The Effects Of The Type And Timing Of Dietary Folate On Memory, Learning, And Gene Expression In Mice, Caleb Schreiner
The Effects Of The Type And Timing Of Dietary Folate On Memory, Learning, And Gene Expression In Mice, Caleb Schreiner
Senior Honors Theses
Folate has been known as an important vitamin for several decades. It is vital in development and epigenetics and is especially known for its involvement in the prevention of neural tube defects in newborns. Due to this ability, a synthetic form of folate, folic acid, was mandated by the government to be reinforced into cereals and grains. This study used a mouse model to determine the effects folic acid and 5-methyltetrahydrofolate have on gene expression and behavior. Since folate is known to be important for epigenetics and neuronal development, this study examined the effects of folate by applying behavioral tests …
Herpes Zoster Patient Education: A Coloring Book Approach, Sophia Charuhas
Herpes Zoster Patient Education: A Coloring Book Approach, Sophia Charuhas
Senior Honors Theses
Shingles, the disease caused by the herpes zoster virus, is a widespread and widely misunderstood illness in the United States. It is preventable, but many at-risk patients do not know what measures they may take to prevent it. Clear communication from physician to patient is crucial for patient understanding of diseases. Many patient education materials on herpes zoster currently available are often unused. It is therefore beneficial to public health to disseminate new mediums of medical communication, and one way of accomplishing this is through adult coloring books. The pathophysiology of herpes zoster virus is here explored and the idea …
Maternal Obesity And Fetal Macrosomia: An Integrative Review Of The Literature Regarding Interventions, Charity Stalcup
Maternal Obesity And Fetal Macrosomia: An Integrative Review Of The Literature Regarding Interventions, Charity Stalcup
Senior Honors Theses
Research suggests pre-pregnancy obesity is associated with an increased risk of macrosomia in the newborn. Since women are expected to gain weight during pregnancy, the standard recommendation of weight loss for obesity is not ideal for this population. In this systematic review of the literature regarding interventions for maternal obesity to reduce fetal macrosomia, 149 articles were screened using three different databases to identify recent randomized controlled trials related to this topic. A total of 11 full text articles were analyzed and included in the review. The articles addressed nutritional, lifestyle, and pharmacological interventions. The results indicated there is currently …
Hutchinson-Gilford Progeria Syndrome Vascular Pathology: A Focused Review, Danielle M. Eschedor
Hutchinson-Gilford Progeria Syndrome Vascular Pathology: A Focused Review, Danielle M. Eschedor
Senior Honors Theses
Hutchinson-Gilford Progeria is an accelerated aging disorder caused by a de novo point mutation in the LMNA gene which codes for an intermediate filament of the nuclear lamina called lamin A. The point mutation at c.1824C>T causes a 50-amino-acid deletion that removes the binding site for Zmpste24, a metalloprotease responsible for defarnesylating prelamin A and producing mature lamin A. Without the ability to be defarnesylated, the mutated protein, called progerin, is more lipophilic and has a myriad of cytotoxic effects. As cardiovascular disease is the most common cause of death in HGPS patients, it is important for both healthcare …
Towards The Development Of A Novel Dna Binding Fluorescent Cell Stain; An Analysis Of Common Dna Dyes And Their Applications, Lauren Kapteyn
Towards The Development Of A Novel Dna Binding Fluorescent Cell Stain; An Analysis Of Common Dna Dyes And Their Applications, Lauren Kapteyn
Senior Honors Theses
Fluorescent deoxyribonucleic acid (DNA) stains that permeate cells are used to observe cellular processes in vivo, making them valuable tools. For the proposal of a new stain, ethidium bromide, cyanine dyes, Hoechst stains, macarpine, DAPI and DRAQ5 are first examined. Features contributing to DNA binding mechanism, toxicity, and cell membrane transport are analyzed for these compounds. The mechanism of DNA binding contributes to the toxicity of the compound. For dyes with well-understood transport mechanisms, multi-drug protein transporters are vital players, though this remains an area for ongoing research as many mechanisms are not well studied. A novel anthraquinone-based compound …
Pediatric Type Ii Diabetes Mellitus: Examining The Upward Trend, Allison Foering
Pediatric Type Ii Diabetes Mellitus: Examining The Upward Trend, Allison Foering
Senior Honors Theses
In recent years, there has been a significant increase in pediatric onset of type II diabetes. This paper will examine elements contributing to this trend. Type II diabetes will be discussed, including related pathophysiology, manifestations, diagnosis, and complications, with differentiation between adult and pediatric onset. Possible prevention and treatment methods appropriate for pediatric patients will also be discussed, along with possible outcomes in pediatric patients that could result from this disease. Overall, this paper will provide insight on the causes of this growing trend, and ways to improve the risks imposed on pediatric patients.
A Closer Look At The Global Management Of Spina Bifida: The Implementation Of Endoscopic Third Ventriculostomy In The Treatment Of Spina Bifida-Related Hydrocephalus In Africa, Caryssa Burckart
Senior Honors Theses
Spina bifida, specifically myelomeningocele, is a debilitating neural tube defect that affects patients and families throughout the world. Traditional management and treatment methods are described, followed by an explanation of why this is often inadequate in providing care for those in impoverished areas of the world, including many regions of Africa. Endoscopic third ventriculostomy is proposed as a promising alternative to traditional methods for treating hydrocephalus, an often associated condition, and the implementation of this treatment method in Africa is explored. In order to relieve Africa of the burden of spina bifida-related hydrocephalus and improve global management of spina bifida, …