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Cytokines And Synthetic Double-Stranded Rna Augment The T Helper 1 Immune Response Of Swine To Porcine Reproductive And Respiratory Syndrome Virus, William A. Meier, Robert J. Husmann, William M. Schnitzlein, Fernando A. Osorio, Joan K. Lunney, Federico A. Zuckermann

School of Veterinary and Biomedical Sciences: Faculty Publications

Immunization of pigs with a modified live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine initially elicits a weak interferon (IFN)-γ response. To improve the immune response, an adjuvant consisting of plasmid encoding either porcine interleukin (IL)-12 or IFN-α was co-administered during vaccination. In the presence of either adjuvant, at least a threefold increase in the primary virus-specific IFN-γ response was observed. While this enhancement was only transient (1 week) when the IL-12 expressing plasmid was used, the effect was not only still apparent at 6 weeks after vaccination in the presence of the IFN-α expressing plasmid but even after …