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Decreased Shedding Of Escherichia Coli O157:H7 By Cattle Following Vaccination With Type Iii Secreted Proteins, Andrew A. Potter, Sandra Klashinsky, Yuling Li, Elizabeth Frey, Hugh Townsend, Dragan Rogan, Galen E. Erickson, Susanne Hinkley, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith, B. Brett Finlay
Decreased Shedding Of Escherichia Coli O157:H7 By Cattle Following Vaccination With Type Iii Secreted Proteins, Andrew A. Potter, Sandra Klashinsky, Yuling Li, Elizabeth Frey, Hugh Townsend, Dragan Rogan, Galen E. Erickson, Susanne Hinkley, Terry J. Klopfenstein, Rodney A. Moxley, David R. Smith, B. Brett Finlay
School of Veterinary and Biomedical Sciences: Faculty Publications
Cattle are an important reservoir of Escherichia coli O157:H7 leading to contamination of food and water, and subsequent human disease. This pathogen colonizes its hosts by producing several proteins such as Tir and EspA that are secreted by a type III secretion system. These proteins play a role in colonization of the intestine, suggesting that they might be useful targets for the development of a vaccine to reduce levels of this organism in cattle. Vaccination of cattle with proteins secreted by E. coli O157:H7 significantly reduced the numbers of bacteria shed in feces, the numbers of animals that shed, and …