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Full-Text Articles in Medicine and Health Sciences
The Bovine Herpesvirus 1 Immediate-Early Protein (Bicp0) Associates With Histone Deacetylase 1 To Activate Transcription, Yange Zhang, Clinton J. Jones
The Bovine Herpesvirus 1 Immediate-Early Protein (Bicp0) Associates With Histone Deacetylase 1 To Activate Transcription, Yange Zhang, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Infected-cell protein 0 encoded by bovine herpesvirus 1 (BHV-1) (bICP0) is necessary for efficient productive infection, in large part, because it activates all 3 classes of BHV-1 genes (U. V. Wirth, C. Fraefel, B. Vogt, C. Vlcek, V. Paces, and M. Schwyzer, J. Virol. 66:2763–2772, 1992). Although bICP0 is believed to be a functional homologue of herpes simplex virus type 1-encoded ICP0, the only well-conserved domain between the proteins is a zinc ring finger located near the amino terminus of both proteins. Our previous studies demonstrated that bICP0 is toxic to transfected cells but does not appear to directly induce …
A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Leads To Impaired Ocular Shedding In Acutely Infected Calves, Melissa Inman, Luciane Lovato, Alan R. Doster, Clinton J. Jones
A Mutation In The Latency-Related Gene Of Bovine Herpesvirus 1 Leads To Impaired Ocular Shedding In Acutely Infected Calves, Melissa Inman, Luciane Lovato, Alan R. Doster, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
Bovine herpesvirus 1 (BHV-1) is an important pathogen of cattle, and infection is usually initiated in the ocular or nasal cavity. Like other alphaherpesviruses, BHV-1 establishes latency in sensory neurons but has the potential of reactivating from latency and spreading. The only abundant viral transcript expressed during latency is the latency-related (LR) RNA, which is alternatively spliced in trigeminal ganglia during acute infection (L. R. Devireddy and C. Jones, J. Virol. 72:7294–7301, 1998). LR gene products inhibit cell cycle progression (Y. Jiang, A. Hossain, M. T. Winkler, T. Holt, A. Doster, and C. Jones, J. Virol. 72:8133–8142, 1998) and chemically …
Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta
Mycobacterium Avium Subsp. Paratuberculosis In Veterinary Medicine, N. Beth Harris, Raul G. Barletta
School of Veterinary and Biomedical Sciences: Faculty Publications
Bacteria of the genus Mycobacterium are gram-positive, acid- fast organisms that include a number of significant human and animal pathogens. Mycobacterium avium subsp. paratuberculosis (basonym M. paratuberculosis) is the etiological agent of a severe gastroenteritis in ruminants, known as Johne’s disease. H. A. Johne and L. Frothingham initially reported the disease in Germany in 1894. However, it was not until 1910 that F. W. Trowt successfully fulfilled Koch’s postulates by growing M. paratuberculosis in the laboratory and reproducing the disease in experimentally infected cattle (46, 148). Johne’s disease is prevalent in domestic animals worldwide and has significant impact on …
Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales
Evidence For Two Mechanisms Of Amino Acid Osmolyte Release From Hippocampal Slices, R. Franco, M. E. Torres-Marquez, H. Pasantes-Morales
School of Veterinary and Biomedical Sciences: Faculty Publications
A 30% decrease in osmolarity stimulated 3H-taurine, 3H-GABA and glutamate (followed as 3H-D-aspartate) efflux from rat hippocampal slices. 3H-taurine efflux was activated rapidly but inactivated slowly. It was decreased markedly by 100 μM 5-nitro-(3-phenylpropylamino) benzoic acid (NPPB) and 600 μM niflumic acid and inhibited strongly by tyrphostins AG18, AG879 and AG112 (25–100 μM), suggesting a tyrosine kinase-mediated mechanism. Hyposmolarity activated the mitogen-activated protein kinases (MAPK) extracellular-signal-related kinase-1/2 (ERK1/ERK2) and p38, but blockade of this reaction did not affect 3H-taurine efflux. Hyposmosis also activated phosphatidyl-inositide 3-kinase (PI3K) and its prevention by wortmannin (100 nM) essentially abolished …
Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde
Persistent Bovine Viral Diarrhea Virus Infection In Us Beef Herds, T. E. Wittum, Dale M. Grotelueschen, K. V. Brock, William G. Kvasnicka, J. G. Floyd, Clayton L. Kelling, K. G. Odde
School of Veterinary and Biomedical Sciences: Faculty Publications
In the summer of 1996, we screened 18,931 calves in 128 beef herds located in five US states for persistent bovine viral diarrhea virus (BVDV) infection. Of these, 76 herds were randomly selected from the client database of collaborating veterinary practices, and 52 herds were suspected by the collaborating veterinarians to have BVDV infection based on history or clinical signs. Serum was obtained from each calf in the cooperating herds prior to 4 months of age and tested for the presence of BVDV by microtiter virus isolation. Information about each of the herds (including management practices, vaccination history, and breeding- …
Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones
Region Of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient For Wild-Type Spontaneous Reactivation Promotes Cell Survival In Tissue Culture, Melissa Inman, Guey-Chuen Perng, Gail A. Henderson, Homayon Ghiasi, Anthony B. Nesburn, Steven L. Wechsler, Clinton J. Jones
School of Veterinary and Biomedical Sciences: Faculty Publications
The latency-associated transcript (LAT) is the only abundant herpes simplex virus type 1 (HSV-1) transcript expressed during latency. In the rabbit eye model, LAT null mutants do not reactivate efficiently from latency. We recently demonstrated that the LAT null mutant dLAT2903 induces increased levels of apoptosis in trigeminal ganglia of infected rabbits compared to LAT+ strains (G.-C. Perng, C. Jones, J. Ciacci-Zarella, M. Stone, G. Henderson, A. Yokht, S. M. Slanina, F. M. Hoffman, H. Ghiasi, A. B. Nesburn, and C. S. Wechsler, Science 287:1500–1503, 2000).The same study also demonstrated that a plasmid expressing LAT nucleotides 301 to …
Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers
Septicemia Associated With Stenotrophomonas Maltophilia In A West African Dwarf Crocodile (Osteolaemus Tetraspis Subsp. Tetraspis), N. Beth Harris, Douglas G. Rogers
School of Veterinary and Biomedical Sciences: Faculty Publications
A 17-year-old male captive West African dwarf crocodile (Osteolaemus tetraspis subsp. tetraspis) died 1 month after fighting with a penmate. Abrasions were present on the head and mandible. Necropsy revealed a vegetative valvular lesion of the left atrioventricular valve, miliary foci of necrosis in the endocardium and myocardium, multiple duodenal and rectal ulcers, and serous atrophy of body fat. Stenotrophomonas maltophilia was isolated in pure culture from lung, liver, and kidney. Gram-negative bacilli were seen histologically in the valvular lesion and in foci of necrosis in the myocardium, liver, spleen, pancreas, kidney, and intestine. Septic thrombi in multiple …
Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo
Legionella Pneumophila Entry Gene Rtxa Is Involved In Virulence, Suat L. G. Cirillo, Luis E. Bermudez, Sahar H. El-Etr, Gerald Duhamel, Jeffrey D. Cirillo
School of Veterinary and Biomedical Sciences: Faculty Publications
Successful parasitism of host cells by intracellular pathogens involves adherence, entry, survival, intracellular replication, and cell-to-cell spread. Our laboratory has been examining the role of early events, adherence and entry, in the pathogenesis of the facultative intracellular pathogen Legionella pneumophila. Currently, the mechanisms used by L. pneumophila to gain access to the intracellular environment are not well understood. We have recently isolated three loci, designated enh1, enh2, and enh3, that are involved in the ability of L. pneumophila to enter host cells. One of the genes present in the enh1 locus, rtxA, is homologous to repeats …