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Full-Text Articles in Medicine and Health Sciences
Genome-Wide Linkage Scan For Loci Influencing Plasma Triglyceride Levels, Juan M. Peralta, Nicholas B. Blackburn, Arthur Porto, John Blangero, Jac C. Charlesworth
Genome-Wide Linkage Scan For Loci Influencing Plasma Triglyceride Levels, Juan M. Peralta, Nicholas B. Blackburn, Arthur Porto, John Blangero, Jac C. Charlesworth
School of Medicine Publications and Presentations
We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic component) of the log-normalized triglyceride levels in plasma. Our …
Modeling Methylation Data As An Additional Genetic Variance Component, Marcio Almeida, Juan M. Peralta, Jose Garcia, Vincent P. Diego, Harald H. H. Goring, Sarah Williams-Blangero, John Blangero
Modeling Methylation Data As An Additional Genetic Variance Component, Marcio Almeida, Juan M. Peralta, Jose Garcia, Vincent P. Diego, Harald H. H. Goring, Sarah Williams-Blangero, John Blangero
School of Medicine Publications and Presentations
High-throughput platforms allow the characterization of thousands of previously known methylation sites. These platforms have great potential for investigating the epigenetic effects that are partially responsible for gene expression control. Methylation sites provide a bridge for the investigation of real-time environmental contributions on genomic events by the alteration of methylation status of those sites. Using the data provided by GAW20’s organization committee, we calculated the heritability estimates of each cytosine-phosphate-guanine (CpG) island before and after the use of fenofibrate, a lipid-control drug. Surprisingly, we detected substantially high heritability estimates before drug usage. This somewhat unexpected high sample correlation was corrected …