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Vitamin D Receptor Gene Bsm1 Polymorphism And Risk Of Breast Cancer, Sana Raza, Roshan Jahan, Anupam Dhasmana, Madan Lal Brahma Bhatt, Mohtashim Lohani, Jamal M. Arif

School of Medicine Publications and Presentations

Breast cancer is a leading cause of death among women, around the world. It is a multifactorial disease involving genetic and environmental factors. Vitamin D is known to modulate biological processes like immune response, bone metabolism, cell growth regulation. The protective actions of vitamin D in cancer development are only sparsely understood, however, evidence shows that vitamin D participates in cell growth regulation, apoptosis and cell differentiation. It has also been implicated in the suppression of cancer cell invasion, angiogenesis and metastasis. The cellular effects of Vitamin D are mediated via Vitamin D receptor (VDR), which is a member of …