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Nicotine Serves As A Feature-Positive Modulator Of Pavlovian Appetitive Conditioning In Rats, M. I. Palmatier, J. L. Peterson, J. L. Wilkinson, Rick A. Bevins
Nicotine Serves As A Feature-Positive Modulator Of Pavlovian Appetitive Conditioning In Rats, M. I. Palmatier, J. L. Peterson, J. L. Wilkinson, Rick A. Bevins
Rick A. Bevins
The present experiments examined whether a nicotine state could set the occasion for a pairing between visual cues and a rewarding outcome in rats. Following nicotine administration, presentation of a conditional stimulus (CS; light-on) was followed by brief access to a sucrose solution. When saline was administered, the same CS was presented but was not followed by any consequence. In Experiment 1, two groups assessed whether rats could acquire this Pavlovian feature-positive discrimination via different training procedures. An anticipatory food-seeking conditioned response (CR) developed during the CS on nicotine sessions but not on saline sessions in both groups. In Experiment …
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Individual Differences In Behavioral Responses To Novelty And Amphetamine Self-Administration In Male And Female Rats, J. E. Klebaur, Rick A. Bevins, T. M. Segar, M. T. Bardo
Rick A. Bevins
Previous work has shown that individual differences in locomotor activity in an inescapable novel environment can predict acquisition of amphetamine self-administration. The current study examined whether individual differences in approach to novelty in a free choice test could also predict amphetamine self-administration. Further, the current study examined whether individual differences in either free choice or inescapable novelty tests could predict responding for a nondrug reinforcer (sucrose) in the presence and absence of amphetamine. Male and female rats were first tested for their response to free choice novelty (playground maze and novelty-induced place preference tests) and inescapable novelty. They were then …
Individual Differences In Response To Novelty, Amphetamine-Induced Activity And Drug Discrimination In Rats, Rick A. Bevins, J. E. Klebaur, M. T. Bardo
Individual Differences In Response To Novelty, Amphetamine-Induced Activity And Drug Discrimination In Rats, Rick A. Bevins, J. E. Klebaur, M. T. Bardo
Rick A. Bevins
Rats mere pre-tested in several individual difference screens - novelty-induced activity, novelty-induced place preference, novel-object interaction, and amphetamine-induced activity. Rats that were more sensitive to the locomotor effects of amphetamine were more active in an inescapable novel environment and displayed a greater preference for a novel environment. All animals were then trained to discriminate amphetamine (1 mg/kg) from saline in a two-bar discrimination procedure using food-maintained responding. After acquisition of the discrimination (mean =37 trials), two amphetamine generalization tests (0.0625,0.125,0.25,0.5, 1.0 and 2.0 mg/kg) were conducted. In the second generalization test, rats that were more sensitive to the activating effect …
Nicotine Enhances Acquisition Of A T-Maze Visual Discrimination: Assessment Of Individual Differences, J. Besheer, Rick A. Bevins
Nicotine Enhances Acquisition Of A T-Maze Visual Discrimination: Assessment Of Individual Differences, J. Besheer, Rick A. Bevins
Rick A. Bevins
In the present report, rats' performance was assessed in five tasks designed to measure behavioral response to different novel stimuli under different experimental situations. Daily nicotine treatment (0, 0.3 or l.0 mg/kg) began after the conclusion of the behavioral tasks and continued throughout the experiment. Training of a T-maze visual discrimination task commenced after 11 days of nicotine pretreatment. As a group, rats treated with the higher dose of nicotine (l.0 mg/kg) made fewer errors to acquire the initial T-maze discrimination than saline-treated controls. Activity induced by an inescapable novel environment (i.e. first behavioral screen) was positively correlated with the …