Medicine and Health Sciences Commons^™

Genetic Analysis Of Endometriosis And Depression Identifies Shared Loci And Implicates Causal Links With Gastric Mucosa Abnormality, Emmanuel Adewuyi, Divya Mehta, Yadav Sapkota, Asa Auta, Kosuke Yoshihara, Mette Nyegaard, Lyn R. Griffiths, Grant W. Montgomery, Daniel I. Chasman, Dale R. Nyholt

Research outputs 2014 to 2021

Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 × 10−4). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (rG = 0.27, P = 8.85 × 10−27). A meta-analysis of endometriosis and depression GWAS (sample size = …

The Relationship Between Abdominal Pain And Emotional Wellbeing In Children And Adolescents In The Raine Study, Oyekoya T. Ayonrinde, Oyedeji A. Ayonrinde, Leon A. Adams, Frank M. Sanfilippo, Therese A. O’ Sullivan, Monique Robinson, Wendy H. Oddy, John K. Olynyk

Research outputs 2014 to 2021

Abdominal pain is a common reason for medical visits. We examined the prevalence, gastrointestinal, and emotional significance of abdominal pain in a population-based cohort serially followed up from birth to 17 years. Children and adolescents from Generation 2 of the Raine Study participated in comprehensive cross-sectional assessments at ages 2, 5, 8, 10, 14 and 17 years. At 17 years, medical history, general health, gastrointestinal symptoms, medications, health practitioner attendance, and self-rated unhappiness were recorded. Longitudinal data regarding abdominal pain or unhappiness, from serial questionnaires, were analysed to identify factors associated with abdominal pain and adverse emotional health at age …

Are Negative Beliefs About Psychosis Associated With Emotional Distress In Adults And Young People With Such Experiences? A Meta-Analysis, Esmira Ropaj, Andrew Jones, Joanne Dickson, Zabina Gill, Peter J. Taylor

Research outputs 2014 to 2021

© 2020 The Authors. Psychology and Psychotherapy: Theory, Research and Practice published by John Wiley & Sons Ltd on behalf of British Psychological Society Objective: Emotional distress, including depression and anxiety, is commonly reported amongst individuals experiencing psychosis. The beliefs individuals hold about the meaning of their psychosis may explain the distress they experience. The current meta-analysis aimed to review the association between beliefs about psychosis experiences and emotional distress. Method: Three electronic databases (PsycINFO, MEDLINE, and CINAHL) were searched using keywords and controlled vocabulary (e.g., Medical Subject Headings) from date of inception to August 2019. A total of 19 …

Exploring The Association Between Recent Concussion, Subconcussive Impacts And Depressive Symptoms In Male Australian Football Players, Sarah Ann Harris, Paola T. Chivers, Fleur L. Mcintyre, Ben Piggott, Max Bulsara, Fiona H. Farringdon

Research outputs 2014 to 2021

Objectives: To explore the association between depressive symptoms and recent head-related trauma (diagnosed concussion, subconcussive impacts) in semiprofessional male Australian Football (AF) players.

Methods: Sixty-nine semiprofessional male players from a West Australian Football League (WAFL) club participated in the study (M age =21.81, SD=2.91 years). Depressive symptoms were measured using the Centre for Epidemiological Studies Depression Scale. Injuries and potential confounding variables (eg, pre-existing mental health condition; alcohol or drug hangovers; experiencing a stressful event) were self-reported anonymously using the WAFL Injury Report Survey. Both tools were administered every 2-weeks over the first 22-weeks of the WAFL season. Controlling for …