Medicine and Health Sciences Commons^™

Validation Of Standard Operating Procedures In A Multicenter Retrospective Study To Identify-Omics Biomarkers For Chronic Low Back Pain, Concetta Dagostino, Manuela De Gregori, Christian Gieger, Judith Manz, Ivan Gudelj, Gordon Lauc, Laura Divizia, Wei Wang, Moira Sim, Iain K. Pemberton, Jane Macdougall, Frances Williams, Jan Vn Zundeert, Dragan Primorac, Yurii Aulchenko, Leonardo Kapural, Massimo Allegri

Research outputs 2014 to 2021

Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study.

Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine). Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories) to obtain robust and reproducible results. To date, no validated …

A Systematic Review Of Geographical Differences In Management And Outcomes For Colorectal Cancer In Australia, Michael J. Ireland, Sonja March, Fiona Crawford-Williams, Joanne F. Aitken, Melissa K. Hyde, Suzanne K. Chambers, Jiandong Sun, Jeff Dunn

Research outputs 2014 to 2021

Background:

Australia and New Zealand have the highest incidence of colorectal cancer (CRC) in the world, presenting considerable health, economic, and societal burden. Over a third of the Australian population live in regional areas and research has shown they experience a range of health disadvantages that result in a higher disease burden and lower life expectancy. The extent to which geographical disparities exist in CRC management and outcomes has not been systematically explored. The present review aims to identify the nature of geographical disparities in CRC survival, clinical management, and psychosocial outcomes.

Methods:

The review followed PRISMA guidelines and searches …

Serum Peptidome Profiling For The Diagnosis Of Colorectal Cancer: Discovery And Validation In Two Independent Cohorts, Hao Wang, Chenghua Luo, Shengtao Zhu, Honghong Fang, Qing Gao, Siqi Ge, Haixia Qu, Qingwei Ma, Hongwei Ren, Youxin Wang, Wei Wang

Research outputs 2014 to 2021

Colorectal cancer (CRC) is one of the most common malignant neoplasms worldwide. Except for the existing fecal occult blood test, colonoscopy and sigmoidoscopy, no widely accepted in vitro diagnostic methods have been available. To identify potential peptide biomarkers for CRC, serum samples from a discovery cohort (100 CRC patients and 100 healthy controls) and an independent validation cohort (91 CRC patients and 91 healthy controls) were collected. Peptides were fractionated by weak cation exchange magnetic beads (MB-WCX) and analysed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDITOF MS). Five peptides (peaks at m/z 1895.3, 2020.9, 2080.7, 2656.8 and 3238.5) were …