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Full-Text Articles in Medicine and Health Sciences
Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991–2016: A Combined Ecological Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse
Contemporary Epidemiology Of Rising Atrial Septal Defect Trends Across Usa 1991–2016: A Combined Ecological Geospatiotemporal And Causal Inferential Study, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2014 to 2021
© 2020, The Author(s). Background: Cardiovascular anomalies are the largest group of congenital anomalies and the major cause of death in young children, with various data linking rising atrial septal defect incidence (ASDI) with prenatal cannabis exposure. Objectives / Hypotheses. Is cannabis associated with ASDI in USA? Is this relationship causal? Methods: Geospatiotemporal cohort study, 1991–2016. Census populations of adults, babies, congenital anomalies, income and ethnicity. Drug exposure data on cigarettes, alcohol abuse, past month cannabis use, analgesia abuse and cocaine taken from National Survey of Drug Use and Health (78.9% response rate). Cannabinoid concentrations from Drug Enforcement Agency. Inverse …
Impacts Of Cannabinoid Epigenetics On Human Development: Reflections On Murphy Et. Al. 'Cannabinoid Exposure And Altered Dna Methylation In Rat And Human Sperm' Epigenetics 2018; 13: 1208-1221, Albert Stuart Reece, Gary Kenneth Hulse
Impacts Of Cannabinoid Epigenetics On Human Development: Reflections On Murphy Et. Al. 'Cannabinoid Exposure And Altered Dna Methylation In Rat And Human Sperm' Epigenetics 2018; 13: 1208-1221, Albert Stuart Reece, Gary Kenneth Hulse
Research outputs 2014 to 2021
Recent data from the Kollins lab ('Cannabinoid exposure and altered DNA methylation in rat and human sperm' Epigenetics 2018; 13: 1208-1221) indicated epigenetic effects of cannabis use on sperm in man parallel those in rats and showed substantial shifts in both hypo- and hyper-DNA methylation with the latter predominating. This provides one likely mechanism for the transgenerational transmission of epigenomic instability with sperm as the vector. It therefore contributes important pathophysiological insights into the probable mechanisms underlying the epidemiology of prenatal cannabis exposure potentially explaining diverse features of cannabis-related teratology including effects on the neuraxis, cardiovasculature, immune stimulation, secondary genomic …
Cannabis Teratology Explains Current Patterns Of Coloradan Congenital Defects: The Contribution Of Increased Cannabinoid Exposure To Rising Teratological Trends, Albert S. Reece, Gary K. Hulse
Cannabis Teratology Explains Current Patterns Of Coloradan Congenital Defects: The Contribution Of Increased Cannabinoid Exposure To Rising Teratological Trends, Albert S. Reece, Gary K. Hulse
Research outputs 2014 to 2021
Rising Δ9-tetrahydrocannabinol concentrations in modern cannabis invites investigation of the teratological implications of prenatal cannabis exposure. Data from Colorado Responds to Children with Special Needs (CRCSN), National Survey of Drug Use and Health, and Drug Enforcement Agency was analyzed. Seven, 40, and 2 defects were rising, flat, and falling, respectively, and 10/12 summary indices rose. Atrial septal defect, spina bifida, microcephalus, Down’s syndrome, ventricular septal defect, and patent ductus arteriosus rose, and along with central nervous system, cardiovascular, genitourinary, respiratory, chromosomal, and musculoskeletal defects rose 5 to 37 times faster than the birth rate (3.3%) to generate an excess of …