Medicine and Health Sciences Commons^™

Depression And Prostate Cancer: Examining Comorbidity And Male-Specific Symptoms, Simon M Rice, John L Oliffe, Mary T Kelly, Prue Cormie, Suzanne K. Chambers, John S Ogrodniczuk, David Kealy

Research outputs 2014 to 2021

Depression in men with prostate cancer is a significant and complex issue that can challenge clinicians' diagnostic efforts. The objective of the current study was to evaluate prototypic and male-specific depression symptoms and suicidal ideation in men with a diagnosis of prostate cancer relative to those with and without comorbidity. The Patient Health Questionnaire-9 (PHQ-9) and Male Depression Risk Scale-22 (MDRS-22) were completed online along with demographic and background variables by 100 men with a diagnosis of prostate cancer ( n = 54 prostatectomy, n = 33 receiving active treatment). Hierarchical logistic regression was used to examine recent (past 2 …

A Prospective Cohort Examination Of Haematological Parameters In Relation To Cancer Death And Incidence: The Busselton Health Study, Niwansa Adris, Anita Chai Geik Chua, Matthew William Knuiman, Mark Laurence Divitini, Debbie Trinder, John K. Olynyk

Research outputs 2014 to 2021

BACKGROUND: Cancer risk is associated with serum iron levels. The aim of this study was to evaluate whether haematological parameters reflect serum iron levels and may also be associated with cancer risk.

METHODS: We studied 1564 men and 1769 women who were enrolled in the Busselton Health Study, Western Australia. Haematological parameters evaluated included haemoglobin (Hb), mean cell volume (MCV), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC) and red cell distribution width (RCDW). Statistical analyses included t-tests for quantitative variables, chi-square tests for categorical variables and Cox proportional hazards regression modelling for cancer incidence and death.

RESULTS: …

Web-Delivered Cognitive Behavioral Therapy For Distressed Cancer Patients: Randomized Controlled Trial, Suzanne K. Chambers, Lee M. Ritterband, Frances Thorndike, Lisa Nielsen, Joanne F. Aitken, Samantha Clutton, Paul A. Scuffham, Philippa Youl, Bronwyn Morris, Peter D. Baade, Jeff Dunn

Research outputs 2014 to 2021

Background: Web-based interventions present a potentially cost-effective approach to supporting self-management for cancer patients; however, further evidence for acceptability and effectiveness is needed.

Objective: The goal of our research was to assess the effectiveness of an individualized Web-based cognitive behavioral therapy (CBT) intervention on improving psychological and quality of life outcomes in cancer patients with elevated psychological distress.

Methods: A total of 163 distressed cancer patients (111 female, 68.1%) were recruited through the Queensland Cancer Registry and the Cancer Council Queensland Cancer Helpline and randomly assigned to either a Web-based tailored CBT intervention (CancerCope) (79/163) or a static …

Melanoma Circulating Tumor Cells: Benefits And Challenges Required For Clinical Application, G. Marsavela, Carlos A. Aya-Bonilla, M. E. Warkiani, Elin S. Gray, Mel R. Ziman

Research outputs 2014 to 2021

The implementation of novel therapeutic interventions has improved the survival rates of melanoma patients with metastatic disease. Nonetheless, only 33% of treated cases exhibit long term responses. Circulating tumor cell (CTC) measurements are currently of clinical value in breast, prostate and colorectal cancers. However, the clinical utility of melanoma CTCs (MelCTCs) is still unclear due to challenges that appear intrinsic to MelCTCs (i.e. rarity, heterogeneity) and a lack of standardization in their isolation, across research laboratories. Here, we review the latest developments, pinpoint the challenges in MelCTC isolation and address their potential role in melanoma management.

Can Exercise Delay Transition To Active Therapy In Men With Low-Grade Prostate Cancer? A Multicentre Randomised Controlled Trial, Daniel A. Galvao, Dickon Hayne, Mark Frydenberg, Suzanne K. Chambers, Dennis R. Taaffe, Nigel Spry, Paul A. Scuffham, Robert S. Ware, Nicolas H. Hart, Robert U. Newton

Research outputs 2014 to 2021

Introduction

Active surveillance is a strategy for managing low-risk, localised prostate cancer, where men are observed with serial prostate-specific antigen assessments to identify signs of disease progression. Currently, there are no strategies to support active surveillance compliance nor are there interventions that can prevent or slow disease progression, ultimately delaying transition to active treatment before it is clinically required. Recently, we proposed that exercise may have a therapeutic potential in delaying the need for active treatment in men on active surveillance.

Methods and analysis

A single-blinded, two arm, multicentre randomised controlled trial will be undertaken with 168 patients randomly allocated …