Medicine and Health Sciences Commons^™

Association Of Dietary Nitrate Intake With The 15-Year Incidence Of Age-Related Macular Degeneration, Bamini Gopinath, Gerald Liew, Annette Kifley, Joshua R. Lewis, Catherine Bondonno, Nichole Joachim, Jonathan M. Hodgson, Paul Mitchell

Research outputs 2014 to 2021

Background

Dietary nitrate, found predominantly in green leafy vegetables and beetroot, is a precursor of nitric oxide. Under- or overproduction of nitric oxide is implicated in the etiology of several eye diseases. However, the potential influence of dietary nitrate intake on age-related macular degeneration (AMD) risk has not been assessed.

Objective

To investigate the temporal association between dietary nitrate intake (from both vegetable and nonvegetable sources) and the 15-year incidence of AMD, independent of potential confounders.

Design

A longitudinal cohort study conducted from 1992-1994 to 2007-2009.

Participants/setting

The Blue Mountains Eye Study is a population-based study of adults aged 49+ …

Reply To Om Shannon Et Al, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson

Research outputs 2014 to 2021

No abstract provided.

Cardiovascular Health Benefits Of Specific Vegetable Types: A Narrative Review, Lauren C. Blekkenhorst, Marc Sim, Catherine P. Bondonno, Nicola Bondonno, Natalie Ward, Richard Prince, Amanda Devine, Joshua Lewis, Jonathan M. Hodgson

Research outputs 2014 to 2021

Adequate vegetable consumption is one of the cornerstones of a healthy diet. The recommendation to increase vegetable intake is part of most dietary guidelines. Despite widespread and long-running public health messages to increase vegetable intake, similar to other countries worldwide, less than 1 in 10 adult Australians manage to meet target advice. Dietary guidelines are predominantly based on studies linking diets high in vegetables with lower risk of chronic diseases. Identifying vegetables with the strongest health benefits and incorporating these into dietary recommendations may enhance public health initiatives around vegetable intake. These enhanced public health initiatives would be targeted at …

Relationship Of Dietary Nitrate Intake From Vegetables With Cardiovascular Disease Mortality: A Prospective Study In A Cohort Of Older Australians, Alex H. Liu, Catherine P. Bondonno, Joanna Russell, Victoria M. Flood, Joshua R. Lewis, Kevin D. Croft, Richard J. Woodman, Wai H. Lim, Annette Kifley, Germaine Wong, Paul Mitchell, Jonathan M. Hodgson, Lauren C. Blekkenhorst

Research outputs 2014 to 2021

Purpose

Short-term trials indicate inorganic nitrate and nitrate-rich vegetables may have vascular health benefits. However, few observational studies have explored the relationship between nitrate intake and long-term cardiovascular disease (CVD) outcomes. The primary aim of this study was to investigate the association of nitrate intake from vegetables with CVD mortality in a sample of older Australians.

Methods

A subgroup of participants without diabetes or major CVD at baseline (1992–1994) were included from the Blue Mountains Eye Study, a population-based cohort study of men and women aged ≥ 49 years. Diets were evaluated using a validated food frequency questionnaire at baseline, …

Nitrate-Rich Vegetables Do Not Lower Blood Pressure In Individuals With Mildly Elevated Blood Pressure: A 4-Wk Randomized Controlled Crossover Trial, Lauren C. Blekkenhorst, Joshua R. Lewis, Richard L. Prince, Amanda Devine, Nicola P. Bondonno, Catherine P. Bondonno, Lisa G. Wood, Ian B. Puddey, Natalie C. Ward, Kevin D. Croft, Richard J. Woodman, Lawrence J. Beilin, Jonathan M. Hodgson

Research outputs 2014 to 2021

Background - Emerging evidence suggests that increasing intakes of nitrate-rich vegetables may be an effective approach to reduce blood pressure.

Objective - Our primary aim was to determine whether daily consumption of nitrate-rich vegetables over 4 wk would result in lower blood pressure.

Design - Thirty participants with prehypertension or untreated grade 1 hypertension were recruited to a randomized controlled crossover trial with 4-wk treatment periods separated by 4-wk washout periods. Participants completed 3 treatments in random order: 1) increased intake (∼200 g/d) of nitrate-rich vegetables [high-nitrate (HN); ∼150 mg nitrate/d], 2) increased intake (∼200 g/d) of nitrate-poor …