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Articles 1 - 5 of 5
Full-Text Articles in Medicine and Health Sciences
Alterations In Erythrocyte Fatty Acid Composition In Preclinical Alzheimer's Disease, Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R. Sohrabi, Prita R. Ash, Preeti Dave, Bethany Ball, Candice Manyan, Kevin Taddei, Roger Chung, Manohar L. Garg, Ralph Martins
Alterations In Erythrocyte Fatty Acid Composition In Preclinical Alzheimer's Disease, Kathryn Goozee, Pratishtha Chatterjee, Ian James, Kaikai Shen, Hamid R. Sohrabi, Prita R. Ash, Preeti Dave, Bethany Ball, Candice Manyan, Kevin Taddei, Roger Chung, Manohar L. Garg, Ralph Martins
Research outputs 2014 to 2021
Brain and blood fatty acids (FA) are altered in Alzheimer’s disease and cognitively impaired individuals, however, FA alterations in the preclinical phase, prior to cognitive impairment have not been investigated previously. The current study therefore evaluated erythrocyte FA in cognitively normal elderly participants aged 65 – 90 years via trans-methylation followed by gas chromatography. The neocortical beta-amyloid load (NAL) measured via positron emission tomography (PET) using ligand 18F-Florbetaben, was employed to categorise participants as low NAL (standard uptake value ratio; SUVR < 1.35, N = 65) and high NAL or preclinical AD (SUVR ≥ 1.35, N = 35) wherein, linear models were employed to compare FA compositions between the two groups. Increased arachidonic acid (AA, p < 0.05) and decreased docosapentaenoic acid (DPA, p < 0.05) were observed in high NAL. To differentiate low from high NAL, the area under the curve (AUC) generated from a ‘base model’ comprising age, gender, APOEε4 and education (AUC = 0.794) was outperformed by base model + AA:DPA (AUC = 0.836). Our …
Possible Role Of Common Spices As A Preventive And Therapeutic Agent For Alzheimer's Disease, Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R. Sohrabi, Ralph Martins, Mana Tanhaei, Mohammad Admin Najaf, Ali Safaei, Rokhsareh Meamar
Possible Role Of Common Spices As A Preventive And Therapeutic Agent For Alzheimer's Disease, Omid Mirmosayyeb, Amirpouya Tanhaei, Hamid R. Sohrabi, Ralph Martins, Mana Tanhaei, Mohammad Admin Najaf, Ali Safaei, Rokhsareh Meamar
Research outputs 2014 to 2021
For centuries, spices have been consumed as food additives or medicinal agents. However, there is increasing evidence indicating the plant-based foods in regular diet may lower the risk of neurodegenerative diseases including Alzheimer disease. Spices, as one of the most commonly used plant-based food additives may provide more than just flavors, but as agents that may prevent or even halt neurodegenerative processes associated with aging. In this article, we review the role and application of five commonly used dietary spices including saffron turmeric, pepper family, zingiber, and cinnamon. Besides suppressing inflammatory pathways, these spices may act as antioxidant and inhibit …
Genome Analysis Of Clostridium Difficile Pcr Ribotype 014 Lineage In Australian Pigs And Humans Reveals A Diverse Genetic Repertoire And Signatures Of Long-Range Interspecies Transmission, Daniel R. Knight, Michael M. Squire, Deirdre A. Collins, Thomas V. Riley
Genome Analysis Of Clostridium Difficile Pcr Ribotype 014 Lineage In Australian Pigs And Humans Reveals A Diverse Genetic Repertoire And Signatures Of Long-Range Interspecies Transmission, Daniel R. Knight, Michael M. Squire, Deirdre A. Collins, Thomas V. Riley
Research outputs 2014 to 2021
Clostridium difficile PCR ribotype (RT) 014 is well-established in both human and porcine populations in Australia, raising the possibility that C. difficile infection (CDI) may have a zoonotic or foodborne etiology. Here, whole genome sequencing and high-resolution core genome phylogenetics were performed on a contemporaneous collection of 40 Australian RT014 isolates of human and porcine origin. Phylogenies based on MLST (7 loci, STs 2, 13, and 49) and core orthologous genes (1260 loci) showed clustering of human and porcine strains indicative of very recent shared ancestry. Core genome single nucleotide variant (SNV) analysis found 42 % of human strains showed …
Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine
Which Food Security Determinants Predict Adequate Vegetable Consumption Among Rural Western Australian Children?, Stephanie L. Godrich, Johnny Lo, Christina R. Davies, Jill Darby, Amanda Devine
Research outputs 2014 to 2021
Improving the suboptimal vegetable consumption among the majority of Australian children is imperative in reducing chronic disease risk. The objective of this research was to determine whether there was a relationship between food security determinants (FSD) (i.e., food availability, access, and utilisation dimensions) and adequate vegetable consumption among children living in regional and remote Western Australia (WA). Caregiver-child dyads (n = 256) living in non-metropolitan/rural WA completed cross-sectional surveys that included questions on FSD, demographics and usual vegetable intake. A total of 187 dyads were included in analyses, which included descriptive and logistic regression analyses via IBM SPSS (version 23). …
The Skin Microbiome: Impact Of Modern Environments On Skin Ecology, Barrier Integrity, And Systemic Immune Programming, Susan Prescott, Danica-Lea Larcombe, Alan Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, Dianne Campbell
The Skin Microbiome: Impact Of Modern Environments On Skin Ecology, Barrier Integrity, And Systemic Immune Programming, Susan Prescott, Danica-Lea Larcombe, Alan Logan, Christina West, Wesley Burks, Luis Caraballo, Michael Levin, Eddie Van Etten, Pierre Horwitz, Anita Kozyrskyj, Dianne Campbell
Research outputs 2014 to 2021
Skin barrier structure and function is essential to human health. Hitherto unrecognized functions of epidermal keratinocytes show that the skin plays an important role in adapting whole-body physiology to changing environments, including the capacity to produce a wide variety of hormones, neurotransmitters and cytokine that can potentially influence whole-body states, and quite possibly, even emotions. Skin microbiota play an integral role in the maturation and homeostatic regulation of keratinocytes and host immune networks with systemic implications. As our primary interface with the external environment, the biodiversity of skin habitats is heavily influenced by the biodiversity of the ecosystems in which …