Medicine and Health Sciences Commons^™

Investigation Of The Relationship Between Chronic Stress And Insulin Resistance In A Chinese Population, Yuxiang Yan, Huanbo Xiao, Sisi Wang, Jing Zhao, Yan He, Wei Wang, Jing Dong

Research outputs 2014 to 2021

Background:

Chronic stress may facilitate the development of metabolic diseases. Insulin resistance is present long before the clinical manifestations of individual metabolic abnormalities. To explore whether chronic stress is an independent risk factor of insulin resistance, we investigated the relationship between the stress system, selected parameters of energy homeostasis, and insulin resistance in a Chinese population.

Methods:

We recruited 766 workers employed at four companies in Beijing. The degree of insulin resistance was determined using the homeostasis model assessment of insulin resistance (HOMA-IR). The highest quartile of HOMA-IR among all study subjects was further defined as insulin resistance in our …

A Case-Control Study In An Orcadian Population Investigating The Rrelationship Between Human Plasma N-Glycans And Metabolic Syndrome, Fiona Mclachlan, Maria Timofeeva, Mairead Bermingham, Sarah Wild, Igor Rudan, Gordon Lauc, Wei Wang, Harry Campbell, James Wilson, Evropi Theodoratou

Research outputs 2014 to 2021

Background:

Alterations in glycosylation patterns have long been known to reflect changes in cell metabolism. In this study, we investigated the relationship between human N-glycan profiles and metabolic syndrome.

Method:

Between 2005 and 2011, 2,155 individuals from the Orkney Islands (UK) were recruited and biological material, alongside phenotypic measures were collected. Individual N-glycan profiles were measured in plasma using weak anion exchange high performance liquid chromatography and calibrated hydrophilic interaction liquid chromatography. Pre-specified criteria were used to identify 564 cases with metabolic syndrome and 1475 controls. We applied logistic regression to test for association between this binary outcome against measured …

Appetite Control With Relevance To Mitochondrial Biogenesis And Activation Of Post-Prandial Lipid Metabolism In Obesity Linked Diabetes, Ian J. Martins

Research outputs 2014 to 2021

In various communities in the developing and developed world the understanding of the ingestion of a healthy diet [1] and hepatic fat metabolism has become of critical importance to the treatment of obesity linked Type 2 diabetes that is now linked to various organ diseases [2]. In the developing world transition to healthy diets has become urgent to prevent insulin resistance [3,4] and the obesity pandemic [5-8]. The liver is the major organ for the metabolism of dietary fat and after consumption of a meal in healthy individuals the fat is rapidly metabolized by the liver. In obesity linked Type …