Medicine and Health Sciences Commons^™

Synthesis And Evaluation Of Sulphonamide Clubbed Thiophenes As Dihydrogen Pteroate Synthase Inhibitors, Pooja A. Chawla, Rupinder Kaur

Research Symposium

Background. Derivatives of thiophene and sulphonamide showed various pharmacological activities including antimicrobial and dihydrofolate reductase (DHFR) inhibition activity. Dihydrofolate reductase and dihydropteroate synthetase enzymes are responsible for bacterial growth and cell proliferation of cancer cells.

Method: In the first step, thiophene was synthesized from cyclohexanone, sulphur and ethyl cyanoacetate by Gewald reaction. Second step involved cyclization of ethyl 2-aminothiophene-3-carboxylate conducted using formamide. In the third step, the carbonyl group was replaced by chlorine in the presence of POCl₃. Then the chlorine group was removed by substituted sulphonamide. A series of derivatives were synthesized and evaluated for …

Ligand-Based Virtual Screening Of Sulfonamide Analogues For The Discovery Of New Carbonic Anhydrase Ii/Ix Inhibitors For Cancer Therapy, Edilsa Valenzuela

Research Symposium

Background: Carbonic anhydrase (CA) II and IX are overexpressed in numerous tumors associated with the hypoxic phenotype and have been involved in poor prognosis and cancer progression, which characterizes them as an attractive therapeutic target. The purpose of this study was to identify sulfonamide analogues as CA inhibitors based on affinity and interactions of molecular docking.

Methods: Through structure and similarity-based virtual screening and applying filters involving a preselection based on functional group, Lipinski's rule of five, mutagenic and tumorigenic characteristics, the best candidates were docked into the isoenzymes. Known reference ligands were used to determine affinity regions favorable for …

Synthesis, Biological Evaluation And Molecular Docking Studies Of Novel 3,5- Disubstituted 2,4-Thiazolidinediones Derivatives, Pooja A. Chawla

Research Symposium

Thiazolidinediones (TZDs) are a new class of antidiabetic drugs, having an insulin sensitizing effect in patients with type 2 diabetes. We report here the synthesis A series of thirteen 2,4-thiazolidinedione derivatives. The 2,4-thiazolidinedione ring's fifth position was used as a site for Knoevenagel condensation to generate the compounds listed in the title. The synthesised derivatives were characterised using a variety of physicochemical and spectral analyses, including IR, Mass, 1H-NMR, ¹³C-NMR, and elemental analysis. By using the carrageenan-induced rat paw edoema method, the alloxan-induced diabetes in wistar rats method, and the FRAP (ferric reducing antioxidant power) method, respectively, the derivatives …

Computational Studies Of Novel Thiazolidine-4-One Based Mao Inhibitors As Neuro-Protective Anti-Parkinson Agents, Abhimannu Shome, Pooja Chawla

Research Symposium

Now a day’s Neurodegenerative diseases such as Parkinson disease is a big concern in the field of medical sciences. In Parkinson’s disease, neurodegeneration occurs in several ways. Monoamine oxidase enzyme is one of them. MAO oxidize the dopamine into its precursor 3,4-dihydroxyphenylacetic acid (DOPAC), which leads to increased ROS and decreased dopamine level. Thiazolidine-4-one pharmacophore has been used to design the desired compound for the target. Thiazolidine-4-one derivatives have been reported to possess anti-oxidant property so the thiazolidine-4-one clubbed compounds were designed and studied via Molecular docking via AutoDock vina, drug-likeness profile by swissADME and pharmacophore modelling through Pharmagist …