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Investigation Of Antidiabetic Of Antidiabetic Activity And Pharmacokinetics In Herbo-Mineral Ayurvedic Formulation ‘Arogyavardhini Gutika In Streptozotocin Induced Wistar Rat, Ruchi Bhattacharya, Bina Gidwani Prof., Shiv Shankar Shukla Prof., Ravindra Kumar Pandey Prof.

Palestinian Medical and Pharmaceutical Journal

Aim: Herbs, spices, and minerals are important therapeutic attributes of ayurvedic formulations. The formulation Arogyavardhini Gutika is mentioned in the essential drug list of the Ayurvedic Formulary of India. It has a claimed safety profile and is used for the treatment of jaundice, leprosy, fever, oedema, obesity, skin disorders, and other hepatic issues. Methods: An in- vitro study was performed by alpha-amylase inhibition using starch, iodine, and dinitrosalicyclic acid. An in-vivo study was performed using a streptozotocin-induced diabetic rat model. Graded doses of Arogyavardhini gutika (200 and 500 mg/kg) were administered orally for 14 days to normal and streptozotocin-induced …