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Full-Text Articles in Medicine and Health Sciences
Human Granulocytic Ehrlichiosis In Europe: Clinical And Laboratory Findings For Four Patients From Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle
Human Granulocytic Ehrlichiosis In Europe: Clinical And Laboratory Findings For Four Patients From Slovenia, Stanka Lotric-Furlan, Miroslav Petrovec, Tatjana Avsic Zupanc, William L. Nicholson, John W. Sumner, James E. Childs, Franc Strle
Other Publications in Zoonotics and Wildlife Disease
Febrile illnesses following a tick bite in patients from Slovenia were evaluated for an ehrlichial etiology. A case of acute human granulocytic ehrlichiosis (HGE) was confirmed by seroconversion to the HGE agent or molecular identification of ehrlichial organisms. Acute infection with the HGE agent was confirmed in four patients. None of the patients had detectable antibodies to the HGE agent at their first visit, but polymerase chain reaction analysis was positive for three patients. All four patients subsequently seroconverted to the HGE agent as shown by high titers of antibody. Clinical features and laboratory findings were similar to those in …
Ecologic Studies Of Rodent Reservoirs: Their Relevance For Human Health, James N. Mills, James E. Childs
Ecologic Studies Of Rodent Reservoirs: Their Relevance For Human Health, James N. Mills, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
Within the past few years, the number of “new” human diseases associated with small-mammal reservoirs has increased dramatically, stimulating renewed interest in reservoir ecology research. A consistent, integrative approach to such research allows direct comparisons between studies, contributes to the efficient use of resources and data, and increases investigator safety. We outline steps directed toward understanding vertebrate host ecology as it relates to human disease and illustrate the relevance of each step by using examples from studies of hosts associated with rodent-borne hemorrhagic fever viruses.
Serologic Evidence Of Infection With Ehrlichia Spp. In Wild Rodents (Muridae: Sigmodontinae) In The United States, William L. Nicholson, Susie Muir, John W. Sumner, James E. Childs
Serologic Evidence Of Infection With Ehrlichia Spp. In Wild Rodents (Muridae: Sigmodontinae) In The United States, William L. Nicholson, Susie Muir, John W. Sumner, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
Rodent (Muridae: Sigmodontinae) blood and sera collected from 14 states were tested for seroreactivity to a cultured isolate of the human granulocytic ehrlichiosis (HGE) agent by using an indirect immunofluorescence assay. Of the 1,240 samples tested, 136 (11%) were found to be reactive at titers of ≥32. Rodents with HGE agent-specific antibodies were found in New York (23% of 491 samples; geometric mean endpoint titer GMT = 441), Connecticut (11% of 100 samples; GMT = 481), California (9% of 32 samples; GMT = 323), Colorado (2% of 212 samples; GMT = 256), Florida (7% of 27 samples; GMT = 362), …
Dietary Habits Of The Common Rodents In An Agrecosystem In Argentina, Barbara A. Ellis, James N. Mills, Gregory E. Glass, Kelly T. Mckee Jr, Delia A. Enria, James E. Childs
Dietary Habits Of The Common Rodents In An Agrecosystem In Argentina, Barbara A. Ellis, James N. Mills, Gregory E. Glass, Kelly T. Mckee Jr, Delia A. Enria, James E. Childs
Other Publications in Zoonotics and Wildlife Disease
Dietary habits of five common rodents in agroecosystems on the central Argentine Pampa were studied for 15 months using microhistological analysis of stomach contents. All five rodent species were omnivorous, but proportions of major dietary items (arthropods, dicot leaves and seeds, monocot leaves and seeds) varied among species and seasons. Akodon azarae largely was entomophagous; arthropods formed 41-62% of the diet in all seasons. The other four species (Calomys musculinus, Calomys laucha, Bolomys obscurus, and Oligoryzomys flavescens) consumed most diet items throughout the year, but relative proportions varied among seasons. Leaves formed a relatively minor proportion of the …
Monoclonal Antibody F89/160.1.5 Defines A Conserved Epitope On The Ruminant Prion Protein, Katherine I. O'Rourke, Timothy V. Baszler, Janice M. Miller, Terry R. Spraker, Ingrid Sadler-Riggleman, Donald P. Knowles
Monoclonal Antibody F89/160.1.5 Defines A Conserved Epitope On The Ruminant Prion Protein, Katherine I. O'Rourke, Timothy V. Baszler, Janice M. Miller, Terry R. Spraker, Ingrid Sadler-Riggleman, Donald P. Knowles
Other Publications in Zoonotics and Wildlife Disease
The transmissible spongiform encephalopathies are a heterogeneous group of fatal neurodegenerative disorders occurring in humans, mink, cats, and ruminant herbivores. The occurrence of novel transmissible spongiform encephalopathies in cattle in the United Kingdom and Europe and in mule deer and elk in parts of the United States has emphasized the need for reliable diagnostic tests with standardized reagents. Postmortem diagnosis is performed by histologic examination of brain sections from affected animals. The histopathological criteria for transmissible spongiform encephalopathies include gliosis, astrocytosis, neuronal degeneration, and spongiform change. These lesions vary in intensity and anatomic location depending on the host species and …
Preclinical Detection Of PrpSc In Nictitating Membrane Lymphoid Tissue Of Sheep, Katherine I. O'Rourke, T. V. Baszler, S. M. Parish, D. P. Knowles
Preclinical Detection Of PrpSc In Nictitating Membrane Lymphoid Tissue Of Sheep, Katherine I. O'Rourke, T. V. Baszler, S. M. Parish, D. P. Knowles
Other Publications in Zoonotics and Wildlife Disease
SHEEP scrapie is the prototype of a heterogeneous group of transmissible spongiform encephalopathies (TSES) which occur in humans, cattle, cats, mink and cervids. TSEs are characterised by the deposition of prion proteins (Prp-Scrapie or PrpSc) in the central nervous system of affected individuals (Prusiner 1982). PrPSc and infectivity have also been detected in the lymphoreticular system of sheep well before symptoms occur (Hadlow and others 1982, Race and others 1992). Detection of PrpSc in lymphoid tissue, such as tonsils or peripheral lymph nodes, has been proposed as a preclinical diagnostic test for scrapie (Ikegami and others …