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Association Of Opioid Metabolism With Aberrant Drug-Related Behaviors Among Non-Malignant Chronic Pain Patients, Eduardo Aguila
Association Of Opioid Metabolism With Aberrant Drug-Related Behaviors Among Non-Malignant Chronic Pain Patients, Eduardo Aguila
Open Access Theses & Dissertations
An estimated 100 million Americans suffer from some form of chronic pain. Chronic opioid therapy (COT) use in non-malignant chronic pain patients (NMCPP) has markedly increased over the past two decades due to growing consensus that COT is suitable for the treatment of moderate-to-severe non-malignant chronic pain. Yet, COT for NMCPP has been widely associated with multiple aberrant drug-related behaviors (ADRB) such as misuse, abuse, diversion, addiction, and pseudoaddiction. One reason for the relative high incidence of ADRB among NMCPP on COT may be genetics-induced medication response variability, which, can result in pharmacotherapy failure and/or toxicity
The present study evaluated …