Medicine and Health Sciences Commons^™

Study Of Ace And Rage Genes Polymorphism In Children With Type 1 Diabetes Presented By Renal Complications, Maha Atef Tawfik, Marwa Said Tawfik El-Sharawy, Naglaa Fathy Barsem

Menoufia Medical Journal

Objectives: To study the relation between angiotensin I converting enzyme (ACE) and receptor for advanced glycation end products (RAGE) genes in children with type 1 diabetes presented by renal complications. Background: In patients with type 1 diabetes, an association has been found between an insertion/deletion (I/D) polymorphism in the gene for ACE and the presence of diabetic nephropathy. Methods: A cross section study was conducted on 50 Egyptian children with type 1 diabetes presented by renal complications from our endocrinology, genetic unit and outpatient clinic in pediatric department, Menoufia University, during a period time from April 2021 to October 2022. …

Phosphorus: The Forgotten Electrolyte In The Paediatric Intensive Care Unit, Fady Mohamed Elgendy, Wafaa Abdelaziz Eladrosy, Muhammad Said El-Mekkawy

Menoufia Medical Journal

Objective To evaluate prevalence of hypophosphatemia and hyperphosphatemia and their association with outcome among critically ill children. Background Phosphorus is essential element for various biological functions but data about serum phosphorus level abnormalities among critically ill children are limited. Patients and methods Prospective observational study including children admitted into Pediatric Intensive Care Unit (PICU). Serum phosphorus was measured on admission, day4, day8, and day12. Pediatric Sequential Organ Failure Assessment (pSOFA) score was calculated on admission. Hypophosphatemia and hyperphosphatemia risk factors were determined. Results Hypophosphatemia and hyperphosphatemia were generally non-severe. Hypophosphatemic patients had higher frequency of sepsis on admission compared with …

Assessment Of Serum Copeptin Levels In Pediatric Patients With Sickle Cell Anemia, Mahmoud Ahmed El-Hawy, Amira M.F. Shehata, Basem Abd El-Fattah El-Gazzar, Ahmed Mostafa Ahmed Esmaiel, Mai El-Sayad Abd El-Hamid El-Saeedy

Menoufia Medical Journal

Objectives: To assess the serum copeptin levels in children with Sickle cell anemia. Background: Sickle cell anemia (SCA) is one of the most common hereditary diseases in the world. Copeptin is the C-terminal part of the prohormone for provasopressin and seems clinically relevant in various clinical conditions. Methods: This is a case control study conducted on 62 subjects, 31 pediatric patients with Sickle cell anemia and 31 healthy children, all aged 1 year to 18 to assess the serum copeptin levels in children with Sickle cell anemia. Who attended pediatric hematology clinics of the Menoufia university hospitals, during a period …

Assessment Of Serum Asymmetric Dimethylarginine Level In Children With Beta-Thalassemia, Seham M. Ragab, Sally M. El-Hefnawy, Eman R.A. Selima, Asmaa A. Mohmoud, Sara A. Elshehaby

Menoufia Medical Journal

Objective

The aim was to evaluate serum asymmetric dimethylarginine (ADMA) level in pediatric patients who received a diagnosis of beta-thalassemia as a predictor of endothelial dysfunction.

Background

Beta-thalassemia is one of most common global autosomal recessive disorders. It causes poor growth and skeletal abnormalities along with hemolytic anemia that regularly involves long-term blood transfusions.

Methods

This cross-sectional study included 60 children divided equally in two groups. The patient group was previously diagnosed with beta-thalassemia major (β-TM), and the control group was healthy subjects who were age, sex, and socioeconomically matched with the patient group. Both groups were evaluated regarding complete …

Feasibility Of Establishing A Neonatal Hearing Screening Program And Measuring Hearing Loss Among Neonates In Dakahlia Governorate, Soheir S. Abou El-Ella, Maha A. Tawfik, Naglaa F. Barseem, Reham M. Abobakr

Menoufia Medical Journal

Objectives

The aim was to evaluate the incidence of hearing impairment among neonates in a rural setup and detect permanent hearing impairment of moderate to severe degree in the frequency range important for speech recognition in neonates, at earliest possible time and help to provide appropriate intervention (medical/surgical/rehabilitation) following the detection of a permanent hearing impairment.

Background

Deafness is the most common curable childhood handicap. It is a well-recognized fact that unidentified hearing impairment can adversely affect optimal speech and language development and therefore academic, social, and emotional development. Universal neonatal hearing screening programs have been implemented in many developed …

Copeptin As A Diagnostic And Prognostic Biomarker For Sepsis In Pediatric Intensive Care Unit, Zein A. Omar, Fady M. El-Gendy, Eman A. Badr, Walaa M. Nabil Ibrahim

Menoufia Medical Journal

Objective

Assessment the role of copeptin as a diagnostic and prognostic biomarker for sepsis in a pediatric intensive care unit (PICU).

Background

Copeptin has been proposed as a promising biomarker for the diagnosis and prognosis of pediatric sepsis in patients with systemic inflammatory response syndrome, sepsis, severe sepsis, and septic shock.

Patients and methods

This prospective case–control study was conducted on 75 patients with sepsis admitted to the PICU of Menoufia University Hospital and 25 healthy controls. All patients are subjected to a detailed history, physical examination, and laboratory investigations. Pediatric Sequential Organ Failure Assessment, Pediatric Risk of Mortality III …

Pentraxin-3 Levels In Β-Thalassemia Major And Its Relationship With Antioxidant Capacity And Total Oxidant Stress, Farida Hussein El Rashedy, Seham Mohammed Ragab, Ashraf Abd El-Fatah Dawood, Ramy Ashmawy Ahmed El Ashmawy, Mahmoud Ahmed El Hawy

Menoufia Medical Journal

Objectives:to evaluate Pentraxin-3 Levels (PTX-3) in pediatric patients with β-thalassemia major, intermedia and minor and its relationship with antioxidant capacity and total oxidant stress.

Background: PTX-3 increases alongside with oxidant stress. Therefore, it can be used as an early diagnostic marker for inflammation.

Methods:A case control study was conducted on 60 pediatric patients with β-thalassemia enrolled from Pediatric Department, Menoufia University. Another 30age and sex matched healthy children were included as a controlgroup. The study was performed during January 2020 to January 2022.

Results: Pentraxin 3 level was higher in all β. Thalassemia patientscompared with control. Total antioxidant capacity was …

Mortality Rate Risk Factors In Neonatal Intensive Care Units In El Giza Governorate, Ghada M. Elmashad, Shimaa A. Ibrahim, Hanan M. Elsayed

Menoufia Medical Journal

Objective: This study aimed to determine the incidence of neonatal mortality percentage in NICUs in Giza Governorate hospitals for early prediction of the disease.

Background: Neonatal mortality rates defined as death of a live born newborn within the first 28 days vary greatly between countries, even within high-income countries.

Methods: A retrospective study was conducted on 155 Egyptian neonates aged from 1 day up to 4 weeks to evaluate the risk factors of the mortality rates at Giza Governorate hospitals NICU during the period from August 2021 to December 2021.

Results: We reported about 6.5% of the studied neonates experienced …

Relation Between Milk Temperature And Feeding Tolerance In Premature Infants, El-Mashad Gm, El Bastawesy N T M, El Sayed H M

Menoufia Medical Journal

Objectives: To evaluate the effect of milk temperature either at warm temperatures closer to freshly expressed breast milk versus at room temperature on feeding tolerance in premature infants.

Background:

Feeding intolerance (FI) is frequent among preterm infants in neonatal intensive care units (NICUs). It has several symptoms and is attributed to many factors including milk temperature.

Methods:

This prospective cohort study included 70 preterm neonates divided into 2 groups; group I included 35 preterm neonates fed with milk at 22– 24°C, closer to room temperature, group II: 35 preterm neonates fed with milk at 32– 34°C, closer to freshly expressed …

Therapeutic Effect Of Probiotics In Neonatal Physiological Jaundice, Ghada Mohamed El Mashad, Ayatmagdy Mohamed Abo El-Mag, Hanan Mostafa Elsayed

Menoufia Medical Journal

Objectives: The aim was to study the effect of probiotics on physiological jaundice.

Background:

Neonatal jaundice is a relatively prevalent disease. Probiotics supplementation therapy could assist to improve the recovery of neonatal jaundice.

Patients and methods: This study was double blinded randomized clinical trial which was prospectively conducted on 88 neonates admitted to neonatal intensive care units of Menoufia university hospital and Damanhour teaching hospital from January 2022 to April 2022. Infants were allocated into two groups: Probiotic group included 44 full term neonates with physiological jaundice who were given the probiotics and Placebo group included 44 neonates who were …