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Assessment Of Right Ventricular Function In Young Patients With Anterior St Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention By Speckle-Tracking Imaging Study, Amal A. Amin, Karim M. Gamal, Mahmoud K. Ahmed, Said S. Montaser Dec 2021

Assessment Of Right Ventricular Function In Young Patients With Anterior St Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention By Speckle-Tracking Imaging Study, Amal A. Amin, Karim M. Gamal, Mahmoud K. Ahmed, Said S. Montaser

Menoufia Medical Journal

Objective To asses s right ventricular (RV) function in patients with anterior ST segment elevation myocardial infarction (MI) undergoing primary percutaneous coronary intervention (PCI) by speckle-tracking imaging study. Patients and methods A total of 150 consecutive patients less than 40 years with anterior ST segment elevation MI and have a single left anterior-descending artery disease who underwent successful primary PCI were enrolled in the study. Patients with a history of prior MI, PCI, coronary-artery bypass graft, those who had a bundle-branch block, PCI, coronary-artery bypass graft, those who had a bundle-branch block on baseline ECG, pulmonary hypertension (primary and secondary), …


Association Between Serum Uric Acid Concentration And Clinical Features Of Psoriasis, Heba Y. Yehia, Naglaa M. Ghanayem, Shawky M. El Farargy Dec 2021

Association Between Serum Uric Acid Concentration And Clinical Features Of Psoriasis, Heba Y. Yehia, Naglaa M. Ghanayem, Shawky M. El Farargy

Menoufia Medical Journal

Objective The aim was to assess linkage between serum uric acid (UA) and clinical features of psoriasis. Background Psoriasis is a chronic immune-mediated skin disease. UA is an end product of purine metabolism and is produced endogenously. Patients and methods A case–control study was conducted on 100 patients with chronic generalized psoriasis (group 1) and 100 age-matched and sex-matched healthy individuals (group 2). Patients of group 1 were subdivided into three subgroups with respect to grades of psoriasis: group 1a included patients with mild psoriasis, group 1b included patients with moderate psoriasis, and group 1c included patients with severe psoriasis. …


Significance Of Excision-Repair Cross-Complementation 1 Gene Polymorphism As A Risk For Hepatocellular Carcinoma, Asmaa I. Gomaa, Asmaa El-Ahmady Mohamed, Emad F. Abdelhalim, Kamal A. Amer, Noran T. Aboelkhair Dec 2021

Significance Of Excision-Repair Cross-Complementation 1 Gene Polymorphism As A Risk For Hepatocellular Carcinoma, Asmaa I. Gomaa, Asmaa El-Ahmady Mohamed, Emad F. Abdelhalim, Kamal A. Amer, Noran T. Aboelkhair

Menoufia Medical Journal

Objectives To study the clinical significance of rs1046282 polymorphism of excision-repair cross-complementation group 1 (ERCC1) as a risk factor for hepatocellular carcinoma (HCC). Background HCC is considered one of the commonest malignancies in the world. ERCC1 gene is implicated in the base-excision repair of DNA. Different polymorphisms in the ERCC1 gene were associated with ovarian, colorectal, gastric, and lung cancers. Patients and methods This case–control study was performed on 100 patients divided into three groups: HCC group, cirrhosis group, and control group. Genotypes of rs1046282 (T/C) single-nucleotide polymorphism in ERCC1 were evaluated via TaqMan allelic discrimination. Logistic regression …


The Relationship Between Nesfatin-1 And Grades Of Diabetic Nephropathy In Type 2 Diabetic Patients, Ahmed R. Tawfik, Alaaeldin A. Dawood, Belal A. Montaser, Mohamed Z. Nooh, Mohamed E. Elnagdy, Mohammed A. Shaaban Dec 2021

The Relationship Between Nesfatin-1 And Grades Of Diabetic Nephropathy In Type 2 Diabetic Patients, Ahmed R. Tawfik, Alaaeldin A. Dawood, Belal A. Montaser, Mohamed Z. Nooh, Mohamed E. Elnagdy, Mohammed A. Shaaban

Menoufia Medical Journal

Objective To assess the relation between plasma nesfatin-1 levels and grades of diabetic nephropathy. Background Nesfatin-1 may be involved in the pathogenesis of diabetic kidney disease. Our study aimed to determine the relationship of nesfatin-1 levels with different grades of diabetic nephropathy in type 2 diabetic patients and to detect the possible association of nesfatin-1 with some metabolic parameters in such diabetic patients. Patienta and methods The study enrolled 120 age-matched patients selected from the outpatient clinic, Alexandria Police Hospital. Patients were divided into four groups: group I included 30 diabetic patients without albuminuria, group II included 30 diabetic patients …


Diabetes Mellitus And Hypertension Are Common Comorbidities Among Covid-19 Hospitalized Patients In Egypt: A Single-Center Retrospective Study, Ashraf A. Askar, Esmail Osman, Mustafa A. Younis, Safaa Khalaf, Tamer Mohamed Dec 2021

Diabetes Mellitus And Hypertension Are Common Comorbidities Among Covid-19 Hospitalized Patients In Egypt: A Single-Center Retrospective Study, Ashraf A. Askar, Esmail Osman, Mustafa A. Younis, Safaa Khalaf, Tamer Mohamed

Menoufia Medical Journal

Background Since the announcement of the COVID-19 catastrophic release in 2019, several studies had been conducted to investigate all the circumstances accompanied by or that have resulted from this viral infection. Objective The aim was to investigate the most common comorbidities and associated clinical risk factors among COVID-19 hospitalized patients admitted to Sohag Fever Hospital, Sohag Governorate, Egypt. Patients and methods In this study, 250 patients of those registered or admitted to Sohag Fever Hospital, Sohag Governorate, Egypt, were included during the pandemic COVID-19 period between October 2020 and February 2021. A total of 150 patients had positive PCR finding …


Impact Of Two Immobilization Systems On Geometry, Dosimetry, And Treatment-Related Toxicities In Rectal Radiotherapy, Hager A. Alagizy, Nabil A. Mobarak, Noha Khaled Aboelfath, Suzy F. Gohar, Yasser A. Rashed Dec 2021

Impact Of Two Immobilization Systems On Geometry, Dosimetry, And Treatment-Related Toxicities In Rectal Radiotherapy, Hager A. Alagizy, Nabil A. Mobarak, Noha Khaled Aboelfath, Suzy F. Gohar, Yasser A. Rashed

Menoufia Medical Journal

Objectives This study aimed to compare the prone position on a belly board device (BBD) immobilization device versus a vacuum bag cushion (VBC) in rectal cancer patients receiving radiotherapy. Background In radiotherapy, it is ideal to adapt to the most favorable, least time-consuming and most cost-effective technique for patient positioning and immobilization with maximum reproducibility. Patients and methods Fifty-five rectal cancer patients scheduled for irradiation were equally randomized to be immobilized with one of the studied immobilization systems and scanned in the prone position. The dose–volume histograms for organs at risk were compared for both immobilization methods and setup accuracy …


Relationship Between Vitamin D Levels And Health-Related Quality Of Life In Maintenance Hemodialysis Patients, Heba E. Kasem, Mahmoud A. Koura, Mohamed O. Sherif, Yassin S. Yassin Dec 2021

Relationship Between Vitamin D Levels And Health-Related Quality Of Life In Maintenance Hemodialysis Patients, Heba E. Kasem, Mahmoud A. Koura, Mohamed O. Sherif, Yassin S. Yassin

Menoufia Medical Journal

Objective This study aimed to investigate the relationship between vitamin D levels and health-related quality of life in maintenance hemodialysis patients. Background Several conditions associated with vitamin D deficiency in end-stage renal disease and hemodialysis patients can indirectly or directly affect the quality of life. Patients and methods The present study included 85 end-stage renal disease patients, subdivided into group I, which included 64 vitamin D-deficient patients, and group II, which included 21 vitamin (D)-efficient patients. Every participant was subjected to sociodemographic, clinical, and laboratory evaluations; each patient underwent a full general assessment of health-related quality of life by the …


Cluster Of Differentiation 163 Expression In Breast Carcinoma: An Immunohistochemical Study, Dalia R. Al-Sharaky, Enas A. El Khouly, Hayam A. Aiad, Marwa M. Dawoud, Norhan S. Kasem Dec 2021

Cluster Of Differentiation 163 Expression In Breast Carcinoma: An Immunohistochemical Study, Dalia R. Al-Sharaky, Enas A. El Khouly, Hayam A. Aiad, Marwa M. Dawoud, Norhan S. Kasem

Menoufia Medical Journal

Objective To determine the expression of the cluster of differentiation 163 (CD163) in invasive breast carcinoma and to correlate it with the clinicopathological parameters, biological markers, and molecular subtypes of breast carcinoma. Background CD163 is a transmembrane scavenger receptor that is specifically expressed by non-neoplastic monocytes/macrophages and by neoplasms with monocytic/histiocytic differentiation. Theory of cell fusion between neoplastic and normal cells has been suggested to play a role in the acquisition of the malignant phenotype. Patients and methods This retrospective case–control study was conducted on formalin-fixed, paraffin-embedded blocks of tissues from 71 patients with invasive breast carcinoma retrieved from the …


Assessment Of Serum Interleukin.6 Level In Children With Bacterial And Viral Meningitis, Ghada M. Elmashad, Hebatallah M. Bahbah, Sara Abdelfattah Sobh, Sherin Sobhy El-Sayed El-Naidany Dec 2021

Assessment Of Serum Interleukin.6 Level In Children With Bacterial And Viral Meningitis, Ghada M. Elmashad, Hebatallah M. Bahbah, Sara Abdelfattah Sobh, Sherin Sobhy El-Sayed El-Naidany

Menoufia Medical Journal

Objectives To evaluate the role of serum interleukin-6 (IL-6) in the diagnosis of meningitis and differentiation between bacterial and viral causes. Background Acute bacterial meningitis (BM) is a pediatric emergency with high mortality and morbidity requiring prompt diagnosis and treatment. Differentiation of BM from viral meningitis (VM) is difficult. Hence, this study was done to evaluate serum IL-6 as a marker to differentiate BM and VM in children and assess its efficacy. Patients and methods This case–control study was conducted on a group of 90 children, comprising 60 with definite acute meningitis diagnosed clinically and confirmed by cerebrospinal fluid analysis …


Inherited Bleeding Disorders Other Than Hemophilia In Pediatrics: Single-Center Experience, Dalia M. Adel, Dina A. Ezzat, Rehab M.A. Elkareem, Yasmen A. Mohamed Dec 2021

Inherited Bleeding Disorders Other Than Hemophilia In Pediatrics: Single-Center Experience, Dalia M. Adel, Dina A. Ezzat, Rehab M.A. Elkareem, Yasmen A. Mohamed

Menoufia Medical Journal

Objective The aim was to study the inherited bleeding disorders other than hemophilia with special emphasis on clinical spectrum, diagnosis, and management. Background Inherited bleeding disorders are a variable group of disorders that vary in incidence and clinical presentations. They include hemophilia A, hemophilia B, von Willebrand disease (VWD), inherited platelet-function disorders (IPFDs), and rare bleeding disorders (factors I, II, V, combined Vand VIII, VII, X, XI, and XIII deficiencies). Patients and methods It is a prospective follow-up study over a period of 5 years, in which patients suffering from bleeding tendency and referred to the hematology clinic were included …


Value Of Transforming Growth Factor-Β2 In Infant's Serum, Mother's Breast Milk, And Its Correlation With Feeding Intolerance, Ahmed A. Khattab, Dalia M. Allahonya, Mohamed S. M. Rizk, Walaa A. M Abdel Hamed, Zein A. Omar Dec 2021

Value Of Transforming Growth Factor-Β2 In Infant's Serum, Mother's Breast Milk, And Its Correlation With Feeding Intolerance, Ahmed A. Khattab, Dalia M. Allahonya, Mohamed S. M. Rizk, Walaa A. M Abdel Hamed, Zein A. Omar

Menoufia Medical Journal

Objective The study value of transforming growth factor-beta2 (TGF-β2) measurement in infant's serum and mother's breast milk and its correlation with feeding intolerance (FI). Background The occurrence of FI remains a concern for care providers in the neonatal intensive care unit and may adversely affect preterm infants. In the intestine, TGF-β2 is involved in regulating inflammatory responses and establishing oral tolerance. The current study was designed to clear whether preterm infants are more susceptible to FI than term infants. Patients and methods A prospective, clinical study on 60 patients admitted to the neonatal intensive care unit and nutritional unit of …


Hypoalbuminemia As A Predictor Of Adverse Outcome In Critically Ill Children: A Prospective Cohort Study, Abeer Y. El-Shamy, Ahmed A. Khattab, Alyaa A. Abdelaziz Dec 2021

Hypoalbuminemia As A Predictor Of Adverse Outcome In Critically Ill Children: A Prospective Cohort Study, Abeer Y. El-Shamy, Ahmed A. Khattab, Alyaa A. Abdelaziz

Menoufia Medical Journal

Objectives To evaluate the incidence of hypoalbuminemia as a predictor of clinical outcome in critically ill pediatric patients. Background Hypoalbuminemia is a common finding in critically ill patients associated with a high risk of poor outcome, but there is limited data on its role in pediatric patients. The aim of this study was to investigate the effect of low albumin levels in pediatric patients on poor prognosis and high risk of mortality in the pediatric intensive care unit (PICU). Patients and methods This was a prospective cohort study conducted at the PICU at El-Bagour Hospital from November 2018 to November …


Lung Ultrasonography To Diagnose Transient Tachypnea Of The Newborn, Amany A. El-Banna, Dalia M. El-Llahony, Fady M. El-Gendy, Waleed A. Mousa Dec 2021

Lung Ultrasonography To Diagnose Transient Tachypnea Of The Newborn, Amany A. El-Banna, Dalia M. El-Llahony, Fady M. El-Gendy, Waleed A. Mousa

Menoufia Medical Journal

Objective This study aimed to diagnose transient tachypnea of newborn (TTN) and differentiate it from respiratory distress syndrome (RDS) using lung ultrasound. Background TTN is a very common cause of neonatal respiratory distress and must be accurately differentiated from other causes of respiratory distress. Participants and methods A prospective observational cohort study was carried out on 120 newborns at the Neonatal Intensive Care Unit, Menoufia University Hospital, admitted with respiratory distress and subjected to an assessment of full history, clinical examination, arterial blood gas, chest radiography, and lung ultrasound. Results On lung ultrasound, TTN was found in 77.5% of cases …


Role Of Ultrasound-Guided Injection Of Corticosteroids And Platelet-Rich Plasma In Treatment Of Supraspinatus Tendon Injuries, Doaa Hosny, Eman A. Abdallah, Mohamed K. Abd-Elmageed, Mohamed R. Elkholy Dec 2021

Role Of Ultrasound-Guided Injection Of Corticosteroids And Platelet-Rich Plasma In Treatment Of Supraspinatus Tendon Injuries, Doaa Hosny, Eman A. Abdallah, Mohamed K. Abd-Elmageed, Mohamed R. Elkholy

Menoufia Medical Journal

Background The shoulder is the site of multiple injuries and inflammatory conditions that lend themselves to therapeutic injection. Therapeutic subacromial injection should be considered after other conservative interventions have been tried. Studies have demonstrated that needle placement is more accurate with image guidance, usually ultrasound (US). Objectives To highlight the role of US-guided injection in the treatment of supraspinatus tendon injuries. Patients and methods This study included 60 patients diagnosed as having supraspinatus tendinosis only or with associated partial thickness tear. All patients were injected under US guidance. A total of 40 patients were injected with corticosteroids, whereas the other …


Relation Between Neuropathic Pain And Serum Levels Of Vitamin D In Egyptian Patients With Rheumatoid Arthritis, Enas A. Abdelaleem, Mervat I. Abdelazeem, Rabab A. Mohamed, Shaimaa S. Anwar Dec 2021

Relation Between Neuropathic Pain And Serum Levels Of Vitamin D In Egyptian Patients With Rheumatoid Arthritis, Enas A. Abdelaleem, Mervat I. Abdelazeem, Rabab A. Mohamed, Shaimaa S. Anwar

Menoufia Medical Journal

Objectives This study aims to measure vitamin D serum levels in Egyptian patients with rheumatoid arthritis (RA) and assess its association with neuropathic pain (NP). Patients and methods The present study was conducted on 70 RA patients. NP was evaluated by the Leeds Assessment of Neuropathic Symptoms and Signs, visual analog scale (VAS) was used to assess the degree of pain, disease activity score (DAS-28) was used to assess activity, and modified health assessment questionnaire (mHAQ) was used to assess quality of life. Serum vitamin D levels were measured for all the patients by ELISA. Results RA patients with NP …


Prediction Of Pelvic Adhesions At Repeat Cesarean Delivery By Assessing Cesarean Scar Characteristics And Striae Gravidarum, Ayman E. Solyman, Hamed E. Ellakwa, Nabih I. Elkhouly, Shaimaa S. R. Eissa Dec 2021

Prediction Of Pelvic Adhesions At Repeat Cesarean Delivery By Assessing Cesarean Scar Characteristics And Striae Gravidarum, Ayman E. Solyman, Hamed E. Ellakwa, Nabih I. Elkhouly, Shaimaa S. R. Eissa

Menoufia Medical Journal

Objectives To investigate the predictive value of striae gravidarum and scar characteristics on the presence of pelvic adhesions at repeat cesarean delivery. Patients and methods The current study was a cross-sectional study conducted in Menoufia University Hospital between November 2019 and November 2020. The study was carried out on patients admitted to the ward fulfilling particular inclusion and exclusion criteria. Preoperatively, abdominal scar characteristics (according to the scar's appearance and color) and striae gravidarum (color and severity using Davey score) were both recorded. Then, at the time of surgery, intra-abdominal adhesions were graded according to the modified Nair's classification. Results …


Comparison Between Early Delivery Versus Expectant Management For Late Preterm Mild Preeclampsia, Ahmed N. Abd-Elhamid, Essam A. Amin, Mennat A. Shabanah Dec 2021

Comparison Between Early Delivery Versus Expectant Management For Late Preterm Mild Preeclampsia, Ahmed N. Abd-Elhamid, Essam A. Amin, Mennat A. Shabanah

Menoufia Medical Journal

Objectives To compare initiation of delivery versus expectant management in women with late preterm mild preeclampsia between 34 and 37 weeks of gestation to determine whether planned delivery reduces maternal adverse outcome without substantial worsening of neonatal outcome. Background In women with late preterm preeclampsia (between 34 and 37 weeks of gestation), the optimal time for delivery is less clear, because limitation of maternal disease progression needs to be balanced against complications for the neonate. Patients and methods This prospective comparative randomized controlled study was conducted by an obstetrician in the period of 1 year in Obstetrics and Gynecology Department …


Correlation Between Anterior Segment Optical Coherence Tomography And Ultrasonography In The Management Of White Cataract, Ahmed I. Basiony, Hisham M. F. El-Mazar, Nadia M. A. Elabd Dec 2021

Correlation Between Anterior Segment Optical Coherence Tomography And Ultrasonography In The Management Of White Cataract, Ahmed I. Basiony, Hisham M. F. El-Mazar, Nadia M. A. Elabd

Menoufia Medical Journal

Background Despite the availability of advances such as laser-assisted capsulotomy, performing a safe continuous curvilinear capsulorhexis still poses a challenge in mature and intumescent cataracts. Objectives To correlate between anterior segment optical coherence tomography and ultrasonography for better management of white cataract. Patients and methods The study was designed as a cross-sectional study of 30 patients. The study protocol was explained to the patients, and all patients were provided written informed consent from October 2019 to February 2020. This study was conducted on 30 eyes of 30 patients (17 males and 13 females; range 44–75-year-old) with white cataract who were …


Ultrasound Biomicroscopic Changes In Anterior Chamber Angle Induced By Phacoemulsification Versus Laser Peripheral Iridotomy, Ahmed M. S. Fayed, Amin F. Ellakwa, Mena S. M. Nicola Dec 2021

Ultrasound Biomicroscopic Changes In Anterior Chamber Angle Induced By Phacoemulsification Versus Laser Peripheral Iridotomy, Ahmed M. S. Fayed, Amin F. Ellakwa, Mena S. M. Nicola

Menoufia Medical Journal

Objectives To make a comparison between the effect of the laser peripheral iridotomy (LPI) and phacoemulsification on the width of the anterior chamber angle by ultrasound biomicroscopy. Background Primary angle-closure glaucoma is a major cause of blindness worldwide. It is a disease of ocular anatomy that is related to pupillary-block and angle-crowding mechanisms of filtration angle closure. Patients and methods A nonrandomized clinical trial was carried out on 36 eyes of 36 patients from October 2019 through October 2020 in Menoufia University Hospital. Results Regarding the comparison between phacoemulsification and LPI groups regarding intraocular pressure (IOP) before and after 1 …


Limbal Versus Pars Plana Approach For Removal Of Congenital Cataract: A Pilot Study, Hatem M. Marey, Manar F. Dawoud, Mohammed S. Abdelaziz, Nader H. Bayoumi, Nihal M. Elshakankiri, Saber H. Elsayed Dec 2021

Limbal Versus Pars Plana Approach For Removal Of Congenital Cataract: A Pilot Study, Hatem M. Marey, Manar F. Dawoud, Mohammed S. Abdelaziz, Nader H. Bayoumi, Nihal M. Elshakankiri, Saber H. Elsayed

Menoufia Medical Journal

Objective A pilot study was conducted to compare the efficacy and safety of limbus versus pars plana approach for the surgical treatment of congenital cataract. Background Bilateral congenital cataract is a common cause of amblyopia, and the surgical treatment is challenging. Patients and methods A pilot study was conducted on children under the age of 2 years with bilateral congenital cataract, stratified into anterior (limbus group) and posterior (pars plana group) surgery approaches. Safety and efficacy were assessed, as well as intraoperative surgeon comments on the ease and feasibility of either technique. Results The study enrolled 34 children with bilateral …


Corneal And Lens Densitometry After Corneal Collagen Cross-Linking With Conventional Versus Enhanced Protocol, Ahmed Basyoni, Mahmoud M. S. Nassar, Saber H. El Sayed Dec 2021

Corneal And Lens Densitometry After Corneal Collagen Cross-Linking With Conventional Versus Enhanced Protocol, Ahmed Basyoni, Mahmoud M. S. Nassar, Saber H. El Sayed

Menoufia Medical Journal

Objective To evaluate the changes in corneal and lenticular density following corneal cross-linking (CXL) with conventual versus enhanced protocol. Background Corneal stromal haze is common after CXL. This is related to the corneal stromal changes occurring after CXL. This can be detected clinically and graded subjectively at the slit-lamp, or measured objectively using Scheimpflug imaging densitometry. Patients and methods This is a prospective randomized controlled clinical trial including all patients with keratoconus undergoing CXL. It included 20 eyes with conventional versus 20 eyes with enhanced method. All patients attended the outpatient clinic unit of Menoufia University Hospital, Shebin El Kom, …


Studies Of Natural Killer Cells In Health And Disease: A Systematic Review, Emad M. El-Shebini, Enas S. Zahran, Mohammed M. El-Ghamrawy, Sabry A. Shoeib Dec 2021

Studies Of Natural Killer Cells In Health And Disease: A Systematic Review, Emad M. El-Shebini, Enas S. Zahran, Mohammed M. El-Ghamrawy, Sabry A. Shoeib

Menoufia Medical Journal

Objective To review the role of natural killer cells (NKCs) in health and disease. Data sources A systematic search of MEDLINE (PubMed, Medscape, and Science Direct, EMF-Portal) and Internet was conducted on all articles published from 1982 to 2019. Regarding study selection, English-language reports of NKCs in health and disease were examined. The initial search presented 145 articles, where 30 satisfied the inclusion criteria. Data extraction Articles not reporting on NKCs in health and disease in the title or abstract were not included. Five independent investigators extracted data on methods. Data synthesis Comparisons were made by structured review, with the …


Nonpharmacological Treatment Of Resistant Hypertension: A Systematic Review, Abdallah M. Kamal, Mohamed N. W. Hassan Dec 2021

Nonpharmacological Treatment Of Resistant Hypertension: A Systematic Review, Abdallah M. Kamal, Mohamed N. W. Hassan

Menoufia Medical Journal

Objective The aim was to review the studies on nonpharmacological treatment of resistant hypertension (R-HTN). Materials and Methods A systematic search of MEDLINE (PubMed, Medscape, Science Direct, and EMF-Portal) and Internet was conducted on all articles published from 1986 to 2019. English-language reports of R-HTN were searched. The initial search presented 112 articles, where 31 fulfilled the inclusion criteria. Articles not reporting on the R-HTN in the title or abstract were not included. A total of 15 independent investigators extracted data on methods. Comparisons were made by structured review with the results tabulated. A total of seven studies were about …


Association Between Colia1 Gene Polymorphism And Bone Marrow Density In Children With Beta-Thalassemia Major, Dalia S. Morgan, Karim I. Sobhy, Rehab M. Abd Elkareem, Waleed M. El Malah Dec 2021

Association Between Colia1 Gene Polymorphism And Bone Marrow Density In Children With Beta-Thalassemia Major, Dalia S. Morgan, Karim I. Sobhy, Rehab M. Abd Elkareem, Waleed M. El Malah

Menoufia Medical Journal

Objectives To determine the incidence of SP1 polymorphism in the COLIA1 gene and its correlation to bone mineral density in patients with beta-thalassemia major (TM). Background B-thalassemia is an autosomal-recessive disorder and considered one of the most severe health problems worldwide. Osteoporosis is a devastating bone disease marked by loss of bone mass, microarchitecture, and increased fracture risk. Polymorphism at the Sp1-binding site of the collagen-type I A1 (COLIA1) gene is thought to be an essential factor in the development of osteoporosis. Methods Alleles S and s in the regulatory site of the COLIA1 gene were investigated in 72 children …


Plasma Circulating Cell-Free Dna Integrity As A Noninvasive Diagnostic Tool In Hepatocellular Carcinoma, Amany I. Afandy, Dalia Hosny, Fatma Younes, Omar Ahmed, Sara M. Eldeeb, Seham Khodeer Dec 2021

Plasma Circulating Cell-Free Dna Integrity As A Noninvasive Diagnostic Tool In Hepatocellular Carcinoma, Amany I. Afandy, Dalia Hosny, Fatma Younes, Omar Ahmed, Sara M. Eldeeb, Seham Khodeer

Menoufia Medical Journal

Background Hepatocellular carcinoma (HCC) is the world's sixth and Egypt's fourth most common cancer, representing the third leading cause of cancer-related deaths worldwide. Circulating cell-free DNA is a type of cell-free nucleic acid derived from apoptotic, necrotic, and living eukaryotic cells. It carries genetic information consistent with tumor cells and has potential for molecular diagnosis of tumors. Objectives To evaluate the clinical significance of plasma circulating cell-free DNA integrity (cfDNAi) as a diagnostic biomarker in HCC compared with alpha-fetoprotein (AFP). Patients and methods This case–control study was carried out on 90 participants who were equally classified into three groups: benign …


Religiosity And The Sexuality Of Women, Mohamed A. Gaber, Shaimaa E. A. Mousa Dec 2021

Religiosity And The Sexuality Of Women, Mohamed A. Gaber, Shaimaa E. A. Mousa

Menoufia Medical Journal

Objective To evaluate the role of religiosity in sexuality of women. Background Religiosity is a characteristic of an individual, and sexual interactions are characteristics of pairs. Sexuality is the constitution or life of the individual as related to 'sex' or exercise of sexual functions. Patients and methods This study was done on 135 married women attending the Outpatient Clinic of Obstetrics and Gynecology in Menoufia University Hospital during the period from May 2020 to August 2020. Results In the present study, most participants were wearing hijab (89.6%) and 5.9% were wearing niqab. Regarding coital frequency in the present study, most …


Quantification Of Serum Melatonin Level And Its Association With Erectile Dysfunction, Mohamed A. Gaber, Mohamed H. A. Ghoniem, Noha R. Bayomy, Reem A. Abdelaziz Hassan Dec 2021

Quantification Of Serum Melatonin Level And Its Association With Erectile Dysfunction, Mohamed A. Gaber, Mohamed H. A. Ghoniem, Noha R. Bayomy, Reem A. Abdelaziz Hassan

Menoufia Medical Journal

Objectives The work aimed to evaluate the role of melatonin in erectile dysfunction (ED) by measuring its level in the serum of these patients and correlating its level with the clinical data. Background One common issue is ED. It is the persistent inability to obtain or maintain a sufficient penile erection for satisfactory sexual performance. One of the hormones secreted from the pineal gland is melatonin. It has antioxidative and antiinflammatory effects. It plays a role in erectile function. In the etiology of ED, oxidative stress is an essential factor, and promising results have been obtained with melatonin treatment in …


Study Of The Diagnostic Role Of Fecal M2-Pyruvate Kinase Level In Patients With Colorectal Cancer, Ahmed Talaat, Atef Aboelsoud, Aymen Elehleh, Belal Montser, Mohsen El Khayat Dec 2021

Study Of The Diagnostic Role Of Fecal M2-Pyruvate Kinase Level In Patients With Colorectal Cancer, Ahmed Talaat, Atef Aboelsoud, Aymen Elehleh, Belal Montser, Mohsen El Khayat

Menoufia Medical Journal

Objective To evaluate the value of fecal M2-pyruvate kinase (M2-PK) level in patients with colorectal cancer (CRC) and other organic colonic disorders. Background Cancer cells are characterized by a high glycolytic rate, which leads to energy regeneration and anabolic metabolism, producing an abnormal expression of M2-PK. Multiple studies have demonstrated that the expression levels of M2-PK are upregulated in numerous cancer types. Patients and methods This prospective study included 30 patients with inflammatory bowel diseases (IBD), 32 CR polyps, and 31 CRC, who were compared with 42 controls. The quantitative M2-PK level was measured in all patients using a highly …


Serum Immunoglobulin G4 In Patients With Nonmalignant Common Bile Duct Stricture, Ahmed R. El-Gazzarah, Ali S. Nada, Hosam M. Seleem, Mary A. Naguib, Omar R. Abdelmaksoud Dec 2021

Serum Immunoglobulin G4 In Patients With Nonmalignant Common Bile Duct Stricture, Ahmed R. El-Gazzarah, Ali S. Nada, Hosam M. Seleem, Mary A. Naguib, Omar R. Abdelmaksoud

Menoufia Medical Journal

Objectives The aim of the present study was to assess the levels of serum immunoglobulin G4 (IgG4) in patients with distal common bile duct strictures in patients with benign biliary stricture (BBS). Background Biliary strictures frequently present a challenge in terms of diagnosis, which requires a multidisciplinary approach. Although up to 30% of biliary strictures can be benign, the vast majority are malignant, the two major malignancies being pancreatic adenocarcinoma and cholangiocarcinoma. One of the underdiagnosed causes of BBS is IgG4-associated cholangiopathy. Increased serum IgG4 levels can be observed in most patients with IgG4-related disease. Patients and methods Sixty-two patients …


Status Of Vitamin D Deficiency Among Preschool Children And Associated Factors In A Rural Area In Upper Egypt, Hala M. E. M. Shaheen, Marwa M. R Abd Elsalam, Safa H. A. Alsayed Dec 2021

Status Of Vitamin D Deficiency Among Preschool Children And Associated Factors In A Rural Area In Upper Egypt, Hala M. E. M. Shaheen, Marwa M. R Abd Elsalam, Safa H. A. Alsayed

Menoufia Medical Journal

Background Vitamin D is a secosteroid hormone that is well known to play a systemic role in calcium homeostasis, skeletal metabolism, cellular differentiation, apoptosis, anti-proliferation, immunosuppression and anti-inflammation. Objectives To estimate the prevalence of vitamin D deficiency and associated factors among preschool children in a rural area in Upper Egypt. Patients and methods A cross-sectional study was carried out on 180 preschool children who attended the selected family health facilities in El-Dakhla District, New Valley Governorate, Egypt. This study was carried out over a timeframe of 24 months (starting from the 1st of February 2019 until the end …