Medicine and Health Sciences Commons^™

Meta-Analysis Of The Efficacy And Safety Of Adjunctive Rosuvastatin For Dyslipidemia In Patients With Schizophrenia, Wei Zheng, Wei Yang, Qing-E Zhang, Xin-Hu Yang, Dong-Bin Cai, Jin-Qing Hu, Gabor S. Ungvari, Chee H. Ng, Marc De Hert, Yu-Ping Ning, Yu-Tao Xiang

Medical Papers and Journal Articles

Background: Metabolic syndrome in patients with schizophrenia is a major health concern. The efficacy and safety of adjunctive rosuvastatin in treating dyslipidemia were controversial.

Aims: To assess the efficacy and safety of adjunctive rosuvastatin for dyslipidemia in patients with schizophrenia.

Methods: We systematically searched for relevant controlled clinical trials from the following databases: PubMed, PsycINFO, Cochrane Library, China Knowledge Network, WanFang Database and Chinese Biomedical Database up to September 28, 2017. Standardized mean difference (SMD) and risk ratio (RR) along with their 95% confidence intervals (CIs) were calculated. The quality of the included studies was assessed using the Cochrane risk …

Effect Of Adjunctive Ranitidine For Antipsychotic-Induced Weight Gain: A Systematic Review Of Randomized Placebo-Controlled Trials, Xiaojing Gu, Rui Chen, Chen-Hui Sun, Wei Zheng, Xin-Hu Yang, Shi-Bin Wang, Gabor S. Ungvari, Chee Ng, Andrei Golenkov, Grace Lok, Lu Li, Ines Chow, Fei Wang, Yu-Tao Xiang

Medical Papers and Journal Articles

This study was a meta-analysis of randomized controlled trials (RCTs) of ranitidine as an adjunct for antipsychotic-induced weight gain in patients with schizophrenia. RCTs reporting weight gain or metabolic side effects in patients with schizophrenia were included. Case reports/series, nonrandomized or observational studies, reviews, and meta-analyses were excluded. The primary outcome measures were body mass index (BMI) (kg/m2) and body weight (kg). Four RCTs with five study arms were identified and analyzed. Compared with the control group, adjunctive ranitidine was associated with marginally significant reductions in BMI and body weight. After removing an outlier study for BMI, the effect of …