Medicine and Health Sciences Commons^™

High Glucose, High Fatty Acid-Induced Toxicity, Oxidative And Metabolic Stress And Alterations In Cell Signalling In Pancreatic Rin-5f Cells: Attenuation By N-Acetylcysteine, Arwa Munassar Ali Thabet Alnahdi

Medical Education Dissertations

Hyperglycaemia and hyperlipidaemia are the main causes of diabetes and obesity-associated complications. Increased oxidative stress, inflammatory responses and altered energy metabolism have been associated with hyperglycaemia and hyperlipidaemia. The concept of ‘glucolipotoxicity’ has arisen from the combination of the deleterious effects of the chronic elevation of levels of glucose and fatty acids on pancreatic β-cells’ function and/or survival. The synergistic effect of both nutrients exacerbates β-cells’ dysfunction over time and creates a vicious cycle of impaired insulin secretion and metabolic disturbances. Though numerous studies have been conducted in this field, the exact molecular mechanisms and causative factors still need to …