Medicine and Health Sciences Commons^™

Analysis Of Growth And Prevalence Of Malnutrition During Total Parenteral Nutrition Weaning: A Methodological Demonstration, Lauren Ashley Kane

Masters Theses

Background: Total Parenteral Nutrition (TPN) is a life-saving intervention which provides nutrition to premature infants with immature gut functioning. Though essential for nutrition provision in the first days of life, TPN is not without risk. Therefore, it is important to introduce feedings into the gut and to wean off TPN when able. During this weaning phase, calorie and protein deficits have been observed to occur. Very few studies have investigated TPN weaning periods, and there are no studies on malnutrition associated with the TPN weaning period in premature infants.

Methods: This study employed a retrospective chart review, with medical …

The Relationship Between Neuroticism, Self-Esteem, And Disordered Eating Attitudes: Examining The Health At Every Size Theory, Liana Cho

Masters Theses

Background. In the modern day treatment of overweight/obesity, conflicting recommendations regarding treatment have been released by the Academy of Nutrition and Dietetics (AND) and advocates of the Health at Every Size (HAES) movement. While the AND have indicated their support for self-monitoring practices, such as keeping a food diary or tracking calories, HAES advocates have claimed that these restrictive practices may result in increased disordered eating tendencies and poor self-esteem.

Subjects. The participants for this study included 410 students at Grand Valley State University. Almost 80% of participants were female, and just over 85% of participants identified as white. …

The Relationship Between Feeding Type And Temporomandibular Joint Morphology In Superfamily Musteloidea, Travis L. Garvin

Masters Theses

Many studies have focused on the soft tissue analysis of carnivores and have demonstrated a relationship between feeding biomechanics and feeding types. Herbivores and omnivores rely heavily on anteroposterior and helical movement of the mandible and teeth for the breakdown of fibrous foods resulting in a flat mandibular fossa while the function of the carnivore TMJ is different, as they need a much stable joint for ripping and tearing of the flesh. I aim to look at whether the bony morphology of the temporomandibular joint (TMJ) can be directly related to feeding type, specifically in the superfamily Musteloidea. I sampled …

Is Tpmt Testing A Predictor Of Duration Of Use Or Long-Term Benefit Of Thiopurine Agents?, Shatoya R. Wilson

Masters Theses

Background: Inflammatory Bowel Disease (IBD) affects as many as 1.3 million Americans and includes both ulcerative colitis (UC) and Crohn’s disease (CD). Recent practices have moved towards using immunomodulators early in the course of disease to prevent disease progression. Patients have shown improved outcomes on immunomodulators compared to aminosalicylates, and reduced risk for tachyphylaxis compared to corticosteroid treatment. Thiopurine agents such as azathioprine and 6-mercaptopurine are immunomodulators often used to treat IBD. Unfortunately, many patients experience cytotoxicity from thiopurine use. Recent studies have shown that patients deficient in thiopurine-S-methyltransferase (TMPT), produce an overabundance of the therapeutic end product, 6-thioguanine nucleotide …

The Effect Of Patterned Sensory Enhancement On Balance And Ambulation In Persons Diagnosed With Parkinson’S Disease, Brittany Barko

Masters Theses

One rehabilitation protocol effective in delaying the symptoms of Parkinson’s Disease (PD) is Lee Silverman Voice Training BIG (LSVT BIG), comprising pre-gait exercises and gait training. This study seeks to determine if combining Patterned Sensory Enhancement (PSE), a music therapy intervention, with LSVT BIG will improve quality of movement. During physical therapy sessions with three participants, a music therapist adapted the PSE stimuli to support each patient’s motor needs, which were then recorded on CD and sent with patients to exercise with at home. Results showed improved balance and ambulation comparing pre- and post- measures of the BERG balance scale …

Evaluating The Toxicity And Formation Of Halobenzoquinones In Point-Of-Use Chlorinated Drinking Water, Stephanie Hung

Masters Theses

Chlorine has effectively reduced the prevalence of waterborne diseases, however there are secondary consequences to this public health advancement. Disinfection byproducts (DBPs) are chemicals formed when chlorine reacts with natural organic matter (NOM) in water. A new class of DBPs, halobenzoquinones (HBQs), has recently been identified and data suggests it could be potentially carcinogenic and up to 1000 times more toxic than some regulated DBPs. So far, in vitro studies have assessed HBQ toxicity without taking into account its transformation in cell media into potentially less toxic compounds. This study evaluated the toxic effects of one HBQ, 2,6-DCBQ, and its …

Real-Time Dengue Forecasting In Thailand: A Comparison Of Penalized Regression Approaches Using Internet Search Data, Caroline Kusiak

Masters Theses

Dengue fever affects over 390 million people annually worldwide and is of particu- lar concern in Southeast Asia where it is one of the leading causes of hospitalization. Modeling trends in dengue occurrence can provide valuable information to Public Health officials, however many challenges arise depending on the data available. In Thailand, reporting of dengue cases is often delayed by more than 6 weeks, and a small fraction of cases may not be reported until over 11 months after they occurred. This study shows that incorporating data on Google Search trends can improve dis- ease predictions in settings with severely …

Clpxp-Regulated Proteins Suppress Requirement For Reca In Dam Mutants Of Escherichia Coli K-12, Amie Savakis

Masters Theses

Double strand breaks (DSB) are a common source of DNA damage in both prokaryotes and eukaryotes. If they are not repaired or are repaired incorrectly, they can lead to cell death (bacteria) or cancer (humans). In Escherichia coli, repair of DSB are typically accomplished via homologous recombination and mediated by RecA. This repair pathway, among others, is associated with activation of the SOS response. DNA adenine methyltransferase (dam) mutants have an increased number of DSB and, therefore, are notorious for being RecA-dependent for viability. Here, we show that the synthetic lethality of Δdam/ΔrecA is suppressed when clpP is removed, suggesting …

Searching For The Fulcrum: Can Accountable Care Organizations Lower Spending By Balancing Specialists-To-Primary Care Providers?, Vishal Shetty

Masters Theses

Background:

While value-based payment models emphasizing care coordination have been widely implemented to improve quality and lower expenditures, supporting empirical evidence is sparse. Our objective was to quantify the impact of specialist-to-primary care physician involvement within accountable care organization (ACO) and its association with lower spending.

Methods:

We conducted a retrospective cohort study of Medicare Shared Savings Program ACOs from 2012-2016 using publicly available data provided by the Centers for Medicare and Medicaid Services at the ACO level. We examined the association between the proportion of primary care services delivered by specialists versus other types of care providers and ACO …

The Effect Of Alpha-Linolenic Acid (Ala) On Endothelial Cell Expression Of Connexin43, Benjamin Pichette

Masters Theses

Atherosclerosis is the leading cause of cardiovascular diseases like myocardial infarctions and strokes. The formation of these atherosclerotic plaques occurs through localized inflammatory responses in blood vessels. Epidemiological evidence suggests omega-3 fatty acids (FAs) decrease vascular inflammation. The omega-3 FAs eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) reduce inflammation through pathways that may include the free fatty acid-4 (FFA-4) receptor. While EPA and DHA are well studied, less is known about the essential omega-3 FA from which they are synthesized: alpha-linolenic acid (ALA). Thus, this study will investigate whether ALA can activate the FFA-4 receptor and thereby contribute to anti-inflammatory …

Effects Of Eicosapentaenoic Acid (Epa) On Mouse Endothelial Cell Health, Spencer C. Pageau

Masters Theses

Cardiovascular disease is the number one killer of adults in the US (~800,000 lives every year:1 in 3 deaths). Evidence suggests omega-3 fatty acids like eicosapentaenoic acid (EPA), found in fish oils, reduce the risk of developing cardiovascular diseases. Many of these diseases are caused by atherosclerotic plaque development in vessels due to endothelial cell damage initiating inflammatory responses. Recent work argues omega-3 fatty acids stimulate anti-inflammatory responses by binding to Free Fatty Acid (FFA) receptors. Inflammatory responses in endothelial cells alter the expression of many proteins that affect the function of those cells. In particular, gap junction protein (connexin: …

Impacts Of Casino Gambling Availability In Plainville, Massachusetts: A Repeated Cross-Sectional Analysis, Danielle M. Venne

Masters Theses

The impacts of the introduction of casino gambling in Plainville, MA and surrounding communities are of interest in developing informed policy. Problem gambling is a public health issue as associated harms include physical and mental illness, impaired relationships with one’s close social network, impacts on school or work, financial difficulties and illegal behavior. The results of surveys prior to and after the introduction of the casino were used to evaluate potential differences in the prevalence of at-risk and problem gambling, associations amongst health and gambling behavior covariates with at-risk and problem gambling status by year, and changes of covariate relationships …

Developmental Exposure To Xenoestrogens: Effects On The Mouse Mammary Gland Development And Response To Estrogen, Durga Kolla

Masters Theses

Humans experience ubiquitous exposures to estrogenic environmental chemicals from food, personal care products, and other industrial and consumer goods. Bisphenol A (BPA), a well-studied xenoestrogen, is known to alter development of estrogen-sensitive organs including the brain, reproductive tract, and mammary gland. Bisphenol S (BPS), which has a similar chemical structure to BPA, is also used in many consumer products, but its effects on estrogen-sensitive organs in mammals has not been thoroughly examined. In our study, pregnant CD-1 mice were orally exposed to BPS or ethinyl estradiol (EE2, a positive control for estrogenicity) from gestational day 9 through postnatal day (PND) …

Traffic Related Air Pollution And Lung Function In Bilateral Lung Transplant Patients, Jennifer A. Gaudreau

Masters Theses

No abstract provided.

Association Of Follicle-Stimulating Hormone And Depression And Depressive Symptoms In Older Postmenopausal Women, Dana Fritz

Masters Theses

Worldwide, between 5 and 18% of postmenopausal women experience depression. While the associations of estrogens with depression have been researched extensively, relations with other postmenopausal hormones remain unclear. We evaluated the association of follicle stimulating hormone (FSH) levels with prevalent depression the Kuopio Ischaemic Heart Disease Risk Factor Study (n = 588). Study participants were postmenopausal women aged 53 to 73 years and not using hormone therapy at enrollment (1998-2001). FSH was measured by radioimmuno-assays. Depression symptoms were measured using a scale based on DSM-III criteria (score range = 0-12), with a score ≥5 indicative of probable depression. We assessed …

Impact Of Bodyweight On Tissue-Specific Folate Status, Genome Wide And Gene-Specific Dna Methylation In Normal Breast Tissues From Premenopausal Women, Armina-Lyn Frederick

Masters Theses

Obesity has reached an epidemic level in the United States. A number of epidemiological studies have established obesity as a critical risk factor for postmenopausal breast cancer (post-BC), whereas a reverse association holds prior to menopause. A significant scientific gap exists in understanding the mechanism(s) underpinning this epidemiological phenomenon, particularly the reverse association between obesity and premenopausal breast cancer (pre-BC). This study aimed to understand how folate metabolism and DNA methylation informs the association between obesity and pre-BC. Fifty normal breast tissue samples were collected from premenopausal women who underwent reduction mammoplasty. We developed and measured the breast tissue folate …

Does The Way Parents Fight Matter? Parents' Conflict Resolution Styles And Children's Internalizing And Externalizing Problems, Alexandrea L. Craft

Masters Theses

Although the negative associations between marital conflict and children’s adjustment are well documented, less is known about how marital conflict styles (e.g., engagement, withdrawal, problem solving and compliance) are related to children’s developmental outcomes. The present study seeks to determine what types of parents’ conflict styles, during the child’s first year of life, are related to children’s behavioral outcomes in the first grade. Analyses examine the hypothesis that more conflictual conflict resolution styles of parents during a child’s infancy will predict poorer child outcomes over time. In addition, given the growing literature documenting the first year of life as a …

Effects Of Chronic Atrazine Exposure On Male Reproductive Function In Sprague Dawley Rats, Josh Quinn

Masters Theses

Estrogens, in addition to testosterone, are much more physiologically relevant to normal sperm production in the testis and overall male fertility than previously thought. Current use herbicides, such as atrazine, are known endocrine disruptors and have been suggested to disrupt male reproductive health. The purpose of this study was to investigate the effect of chronic atrazine exposure on male reproductive function in Sprague Dawley rats. Three groups of rats were treated until 7 months of age. The first group was the control vehicle and given only water. The second group was given a low dose of atrazine (0.1 mg/kg) and …

Use Of The Montreal Cognitive Assessment As An Early Indicator Of Tumor Progression In Patient With Stage Iii And Iv Gliomas, Eric David Laney

Masters Theses

Patients diagnosed with high grade glioma have a short life expectancy due to rapid progression of disease following and/or during treatment. Magnetic resonance imaging (MRI) is the primary method of surveying tumor progression, but is costly, lengthy in duration and often uncomfortable for the patient. An alternative to MRI that is cost efficient and patient friendly is of great interest to the medical community. If this alternative could also provide advanced notification of disease progression, then this patient population would have the opportunity for earlier treatment and the potential for greater efficacy. To pursue this concept, we assessed whether the …

Incidence, Clinical Manifestations And Risk Factors Of Acute Rheumatic Fever: A Systematic Review And Meta-Analysis Of The Global Perspective, Jessica Fritzler

Masters Theses

Acute Rheumatic Fever (ARF) is a system-wide disease in which chronic, wide spread inflammatory changes occur in response to a group A streptococcal (GAS) infection that most often affects children and adolescents and those from developing countries. The aim of this study is to calculate the global incidence of ARF and identify the frequencies of major and clinical manifestations and risk factors globally to provide a better indication of the burden of disease and additional information on the dispersion of manifestations and risk factors. A meta-analysis was conducted by pooling cross-sectional and cohort studies, and Morbidity and Mortality Weekly Reports …

Organocatalyzed Synthesis Of Epoxides From Chalcones Utilizing Amino Acids, Sabrina N. Kegeler

Masters Theses

The epoxide functional group is important throughout the chemical and pharmaceutical industries, as well as in nature. In the chemical industry, epoxides are present in resins and fragrances. In the pharmaceutical industry, epoxide-containing compounds are used as intermediates in the manufacturing of drugs. In nature, many natural products contain epoxide groups and are used for medicinal purposes, and for models to create synthetic molecules.

One approach to epoxide synthesis involves the use of an alkene precursor, a base, and an oxidizing agent. This is where my investigations began. The first step was to optimize the epoxidation reaction, examining substrate scope, …

Exploring The Relevance Of Art Therapy In Public Education, Brandy A. Jarrell

Masters Theses

This thesis will explore art education as a therapeutic tool in a public education system. This topic will serve as a continuation of research that I conducted previously but will bring more focus upon bringing a certified art therapist into public school districts in West Virginia. Data will be collected through student surveys, interviews of professional art therapists, and administrative officials. Data will also be collected through a review of the literature surrounding the benefits of art therapy to children and adolescents. Through these sources I will explore the attitudes, beliefs, and practices of educational professionals, art therapists, administrators and …

A Survey Of Perceptions And Professional Boundaries Between Music Therapy And Speech-Language Pathology, Jennifer Rose Fromius

Masters Theses

The purpose of this study is to examine the relationship between music therapists and speech-language pathologists in order to gain a better understanding of professional boundaries within each profession, frequency of co-treatment between the two professions, and perceptions of referral in clinical practice. Data for this research were collected through two online questionnaires with parallel sets of questions, which were distributed to a sample of boardcertified music therapists (MT-BC) and speech-language pathologists (CCC-SLP). Quantitative and qualitative data collected from the survey (N= 283; n = 45 MT-BC, n = 238 CCC-SLP) are analyzed to determine if there are correlations and …

Language Profiles Of Children Who Have Experienced Complex Trauma And Fetal Alcohol Spectrum Disorders, Christel G. Ciolino

Masters Theses

Children who experience maltreatment and children with Fetal Alcohol Spectrum Disorders (FASD) have similar neurological differences and are at risk for language impairments. However, limited research has been conducted to analyze their specific skill sets. To address this limitation, retrospective data from the Children’s Trauma Assessment Center of Southwest Michigan were analyzed. The linguistic profiles of 79 children with histories of varying numbers of traumatic experiences and comorbid FASD statues are compared in the areas of semantics, syntax, pragmatics, and social communication. Individuals had high pass rates on the CELF-5 Screening Test and high overall scores on the Pragmatic Protocol-Revised …

Vitamin D Status And Bone Health Among Young Adult Women, Caroline Stone

Masters Theses

Background:

Osteoporosis is estimated to affect 200 million women in the world, affecting 10% of women aged 60, 20% of women aged 70, 40% of women aged 80 and 67% of women aged 90. Osteoporosis is characterized by low bone density and increases the risk for fractured bones; however, it may be prevented with modifiable factors such as supplements, diet, and physical activity. Vitamin D deficiency leads to bone mineral density loss, as Vitamin D₃ is responsible for calcium absorption into the bones. Bone consolidation is believed to occur between 20 and 30 years old; thus, attaining peak bone …

The Role Of Contact And Empathy In Stigma Toward Individuals With Mental Illness Among Mental Health And Non-Mental Health Professionals, Quincy A. Knolhoff

Masters Theses

This study was designed to help identify the factors that predict people's stigmatized attitudes toward individuals with mental illness. Corrigan (2002) suggested that stigmatized beliefs about individuals with mental illness may be detrimental to the potential recovery of these individuals, their self-esteem, empowerment, and their integration into society. One factor that has been found to reduce this stigma is personal contact with mentally ill individuals (Corrigan et al., 2002). Additionally, research has shown that empathy and principled moral reasoning are negatively correlated with prejudice, or stigma (McFarland, 2010). The current study examined level of contact, employment in a mental health …

Assessment And Analysis Of Receptive And Expressive English Language Development In Spanish Speaking Ells And Native English Speakers Using The Pre-Klba, Candace Laprairie

Masters Theses

The purpose of this study is to examine the trends and differences in receptive and expressive English language development in native English speakers and Spanish-speaking English language learners (ELL). It also aims to analyze the relationship between auditory comprehension and narrative production skills and semantic skills and narrative production skills in native English-speakers and Spanish-speaking ELLs. Eighty-three preschool-aged children (17 Spanish-speaking ELLs and 66 Native English-speakers) were administered the Pre-Kindergarten Language Benchmark Assessment (Pre-KLBA) in Fall 2015, Winter 2016, and Spring 2016. This study utilized a three by two ANOVA to evaluate and determine: 1) If there are differences in …

Social Anxiety And Problematic Drinking In College Students: Examining Potential Mediators, Carissa Gutsmiedl

Masters Theses

Social anxiety and problematic drinking are among the most prevalent disorders present in the college population. Having one or both of these disorders while in college can be detrimental to academic performance and can increase dropout rates. Social anxiety has been found to precede problematic drinking in previous research. The purpose of this study was to help determine what variables may explain this relationship (i.e., mediators). The current study tested whether emotion regulation difficulties, drinking motives, alcohol outcome expectancies, and self-discrepancy mediated the relationship between social anxiety and problematic drinking among college undergraduates (N = 135). Results indicated that emotion …

A Qualitative Case Study On Best Practices Of Emotional Support Animal Policies, Jordan E. Dadez

Masters Theses

This study sought to understand the best practices and protocols of Emotional Support Animal policies in residential life. A qualitative case study was conducted to provide insight on the best practices of residential life Emotional Support Animal Policies. Four participants from institutions with established policies were interviewed to gain understanding of these protocols and policies, what is involved in the approval and accommodations process, and what challenges the participants face. The results showed a need to evaluate and change the current process that most institutions utilize for Emotional Support Animal approval. The approval process and accommodations process are two separate …

The Relationship Between Resilience, Coping, And Social Media, Lillian N. Hurley

Masters Theses

This study was designed to explore relationships between measures of resilience, coping strategies, social media usage, and depression. Resilience refers to one's ability to endure and recover from adversity. Many theories about what contributes to the development resilience have been explored without a clear consensus. Taormina (2015) argued that adult personal resilience is comprised of four dimensions - determination, endurance, adapatability, and recuperability. Coping, a construct related to resilience, is the process of regulating emotions, cognition, behavior, physiological responses, and the environment in response to stressful events. Past research indicated those with poorer mental health have the tendency to use …