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Loma Linda University Electronic Theses, Dissertations & Projects
Neonatal Hypoxia-Ischemia; Cerebral Blood Flow; Neurological Impairment
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Gene Delivery Of Adenoviral-Tmbim6 Vector Protects The Neonatal Brain After Hypoxic-Ischemic Injury, Desislava Doycheva
Gene Delivery Of Adenoviral-Tmbim6 Vector Protects The Neonatal Brain After Hypoxic-Ischemic Injury, Desislava Doycheva
Loma Linda University Electronic Theses, Dissertations & Projects
Neonatal hypoxia ischemia (HI) is an injury caused to the immature brain due to reduced cerebral blood flow which is associated with life-long neurological impairments. HI causes oxidative protein folding in the endoplasmic reticulum (ER), which results in ER stress. Generation of reactive oxygen species (ROS), from cytochrome P450 members (CYP) and NADPH-P450 reductases (NPR), in combination with activation of the unfolded protein response (UPR) are two major consequences of ER stress that cause oxidative damage and cell death. Herein we identified the role of Bax Inhibitor-1 (BI-1), an evolutionary conserved protein encoded by the Transmembrane Bax inhibitor Motif Containing …