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Full-Text Articles in Medicine and Health Sciences
African Americans Navigating Through Relationships Towards Marriage: A Grounded Theory Study, Moosgar Yrveens Borieux
African Americans Navigating Through Relationships Towards Marriage: A Grounded Theory Study, Moosgar Yrveens Borieux
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of this study was to explore if and how early parent-participant relationships affect subsequent intimate relationships among African American couples. Given the clear gap between African Americans’ attitudes about marriage and the data that show them to be the least likely to be married among other racial or ethnic groups in the United States of America, a unique conceptualization [Life Course Developmental framework, Object Relations theory, Symbolic Interactionism perspective] was used to explore the role that early key figure-child social interactions potentially have in influencing young African Americans interactions with their significant others. To carry out the research …
The Role Of Glucocorticoid Signaling In Prostate Cancer Health Disparities, Leanne W. Burnham
The Role Of Glucocorticoid Signaling In Prostate Cancer Health Disparities, Leanne W. Burnham
Loma Linda University Electronic Theses, Dissertations & Projects
African-American men are more likely to develop aggressive prostate cancer (PCa) and die from the disease than other ethnic groups. Glucocorticoid signaling is a contributing biological factor to worse PCa prognosis, and is emerging as a key driver of PCa progression in the absence of androgens. The mechanism involves glucocorticoids binding to glucocorticoid receptor (GR) and bypassing the androgen receptor (AR) signaling pathway to activate AR-target genes that promote tumor aggressiveness and therapy-resistance. This is problematic as African-American men have hypersensitive GR signaling and chronically-elevated levels of glucocorticoids linked to cumulative stressful life events. To explore the role of glucocorticoid …