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Full-Text Articles in Medicine and Health Sciences
The Effect Of Anthropogenic Environmental Modifications On Malaria Vectors In Amazonian Peru And Brazil, Catharine Prussing
The Effect Of Anthropogenic Environmental Modifications On Malaria Vectors In Amazonian Peru And Brazil, Catharine Prussing
Legacy Theses & Dissertations (2009 - 2024)
Malaria is the most deadly vector borne disease, causing substantial morbidity and hundreds of thousands of deaths worldwide each year. In the Americas, the incidence of malaria has increased steadily since 2014. The factors driving continued malaria transmission are complex and highly variable across endemic areas. These factors include inadequate access and financial commitment to prevention, diagnosis, and treatment, and a failure to target interventions to heterogeneous malaria transmission patterns and vector populations. Nyssorhynchus darlingi (formerly Anopheles darlingi), the predominant malaria vector in Latin America, is known for behavioral, phenotypic, and genetic variability across its range, which allow it to …
The Effects Of Landscape On Malaria Vectors Of The Neotropics, William David Lainhart
The Effects Of Landscape On Malaria Vectors Of The Neotropics, William David Lainhart
Legacy Theses & Dissertations (2009 - 2024)
Worldwide malaria control efforts have had varying degrees of success, leaving many countries either eliminating malaria or controlling malaria. In order to maintain forward momentum toward malaria elimination, malaria-eliminating and –controlling countries require different information regarding risk factors, spatial distributions of cases and vectors, vector biology metrics, and vector population genetics. The goal of this dissertation work was to provide information that addresses the knowledge gaps preventing the creation of effective vector and malaria control programs in one malaria-eliminating country (Panama) and two malaria-controlling countries (Peru and Brazil). Case data from Panama were analyzed to assess differences in risk factors …
Detection And Epidemiological Patterns Of Drug Resistance Mutations In Nys Plasmodium Falciparum Clinical Malaria Specimens, Jennifer L. Conaway
Detection And Epidemiological Patterns Of Drug Resistance Mutations In Nys Plasmodium Falciparum Clinical Malaria Specimens, Jennifer L. Conaway
Legacy Theses & Dissertations (2009 - 2024)
Plasmodium falciparum is a human-infective parasite that causes the most severe form of malaria. Resistance to a wide spectrum of antimalarials has been documented in this species, and single strains may be resistant to several drugs. A new technology, pyrosequencing, has been shown to be useful for the rapid detection of SNPs involved in drug resistance. It can be used in a clinical setting and readily detects new mutants, which frequently appear in this species due to strong selection for antimalarial resistance. In this study, a pyrosequencing protocol was developed to identify mutations in the Plasmodium falciparum genes Pfcrt, Pfdhps, …