Medicine and Health Sciences Commons^™

Characteristics And Causal Factors For The Receptive-Expressive Gap In Typically Developed Spanish-English Adult Bilinguals, Rachael Janelle Javaherian

LSU Master's Theses

A receptive-expressive language gap occurs when a standardized receptive score is statistically greater than an expressive score in either a primary or a second language. In bilingual children, gap studies already exist for determining language impairment. In adults, there are few studies; nevertheless, one needs to distinguish between typical language patterns of bilingualism due to non-pathological loss of L1 skills versus problems resulting from accidents, disease, or age. To this end, the present study attempted to expand findings of studies by Gibson et al. (2012 and 2014) that focused on analysis of the gap and possible factors influencing its existence …

Role Of Aim2 Inflammasome In Pulmonary Host Defense Against Staphylococcus Aureus-Induced Pneumonia, Bibek Dhakal

LSU Master's Theses

Bacterial pneumonia is the leading cause of death in children under the age of five, claiming the lives of two million children each year. Staphylococcus aureus is the extracellular Gram-positive bacteria that causes necrotizing pneumonia. Moreover, the spread of antibiotic-resistant and hypervirulent strains has made treatment more challenging. Absent in melanoma 2 (AIM2) is a dsDNA-sensing cytosolic innate immune receptor that activates inflammasomes and is crucial for host defense against intracellular bacteria and DNA viruses. However, its role in extracellular bacterial pathogen-induced pneumonia is unclear. Therefore, understanding how AIM2 initiates host responses during Staphylococcus aureus is crucial for the development …

Informing Viral Surveillance Of Oropouche Virus: An Emerging Arbovirus, Christine E. Walsh

LSU Master's Theses

Arboviruses are viruses transmitted by hematophagous arthropod vectors. Many of these viruses pose a threat to human health. While some infections may be asymptomatic, others may produce febrile illness, or manifest in life threatening conditions. Symptomatic diagnosis of patients with generalized febrile illness can be confounded due to the various diseases that present clinically in the same manner, and a lack of available diagnostic tests. Surveillance efforts can be used to create awareness about the prevalence of neglected tropical arthropod-borne pathogens, such as Oropouche virus (OROV), and inform preparedness measures for disease outbreaks (SURVEILLANCE SENTENCE). OROV is an arbovirus and …

Modeling Of Island Block Scatter For Intensity Modulated Bolus Electron Conformal Therapy, Joseph G. Scotto

LSU Master's Theses

Purpose: Bolus electron conformal therapy (BECT) benefits treatment of the post-mastectomy chest wall, head and neck, paraspinal muscles, and extremities. Patient dose heterogeneities caused by bolus can be reduced through intensity modulation (IM) across the incident electron beam. This requires passive radiotherapy intensity modulation for electrons (PRIME) devices, which utilize tungsten pins (island blocks) imbedded in machinable foam. IM-BECT treatment planning requires accurate dose calculation using the pencil beam redefinition dose algorithm (PBRA). Currently, the PBRA models island blocks as perfect collimators. This work explores models to account for electrons scattering into and out of the sides of island blocks. …

Structural Shielding Considerations For Vmat, Ana Lucia Dieguez

LSU Master's Theses

Introduction: As noted in National Council on Radiation Protection and Measurements (NCRP) Report 151, the medical physicist or other qualified expert has the responsibility to keep abreast of any new technology or treatment method that could potentially impact structural shielding design. Volumetric arc therapy (VMAT) became prevalent after the publication of Report 151 and thus was not explicitly addressed in Report 151. If the shielding-related characteristics of VMAT differ enough from the expectations of Report 151, especially in the circumstance of a vault utilized exclusively for VMAT, a shielding design based on Report 151 could potentially be inadequate. The …

Characterizing Receptive Vocabulary Knowledge In Minimally Verbal Children With Autism Spectrum Disorder, Allison Menting

LSU Master's Theses

Background: Delayed or impaired language skills are common characteristics of children with autism spectrum disorder (ASD). Currently, there is little research examining the receptive language profile in children with ASD, and even less is known about children with ASD who are minimally verbal. The current study aimed to characterize the receptive vocabulary profile of minimally verbal children with ASD and to examine whether this profile differs from their typically developing peers. Methods: Participants included 31 minimally verbal children with ASD, aged 60-118 months, who were reported to produce between 0-10 words, 124 typical developing toddlers, aged 9-14 months, who were …

Validation Of A Respiratory Gating System For Automated Delivery Of The Deep Inspiration Breath-Hold Technique, Michael G. Stock

LSU Master's Theses

Purpose: To validate the performance of a respiratory gating system for the automated delivery of the deep inspiration breath-hold (DIBH) technique.

Methods: The gating system utilized an automatic gating interface (Elekta Response) which connected a marker-based respiratory motion monitoring system to the linear accelerator control system. The gating system was characterized dosimetrically and temporally using two distinct approaches. Central-axis output and energy constancy were evaluated across 8 beam-matched linear accelerators. Additionally, a representative set of 5 treatment plans were delivered both non-gated and gated to a 2D diode array (MapCHECK). The respiratory motion monitoring system optically tracked a reflective marker …

Anesthetic Combination Of Alfaxalone, Dexmedetomidine And Hydromorphone For Comparison Of Endoscopy-Guided Intubation And Blind Orotracheal Intubation In Domestic Rabbits (Oryctolagus Cuniculus), Stephanie Reabel

LSU Master's Theses

Domestic rabbits have a high risk of anesthesia-related mortality compared to other companion animals. Factors that may contribute to increased mortality include drug-induced cardiopulmonary effects (Grint & Murison 2008; Navarrete-Calvo et al. 2013), difficulty performing intubation (Aeschbacher 1995; Flecknell 2016; Wenger et al. 2017) or damage to laryngeal and tracheal tissues following orotracheal intubation (Grint et al. 2006; Phaneuf et al. 2006; Engbers et al. 2017).

Alfaxalone is a neuroactive steroid that produces induction of anesthesia and cardiorespiratory depression in a dose-dependent manner when injected intravenously. The ability to induce anesthesia via an intramuscular (IM) route has several advantages in …

Five Love Languages: Assessment Of Marital Satisfaction In African American Couples, Freddricka C. Lee

LSU Master's Theses

This mixed-methods study examined marital satisfaction among five (n = 10) heterosexual, African American married couples. In particular, this study examined how acknowledging a partner’s love language (Chapman, 1995) can affect these couples’ level of marital satisfaction. The participants were native to the South and ranged from 26-55 years of age. Quantitative and qualitative analysis of the data revealed couples were satisfied with their marriages. Although only marginally significant, the findings also revealed acknowledging a spouse’s love language was positively related to higher levels of marital satisfaction. Seven themes emerged throughout the interviews, namely communication; financial stability; understand a spouse’s …

Voice Therapy: Racial Disparities In Adherence And Clinically Significant Outcomes, Amber D. Burks

LSU Master's Theses

Voice therapy is evidence-based, behavioral intervention that can reduce functional and organic voice disorders. Despite its proven effectiveness, non-adherence to voice therapy is still an issue. Research shows that an estimated 65% of patients who initiate voice therapy drop out before reaching therapeutic goals. Voice therapy outcomes are largely dependent on patients’ adherence to treatment regimens, but there is limited information concerning factors that may be associated with voice therapy adherence and therapeutic outcomes for patients who successfully complete voice therapy.

The purpose of this study was to investigate which demographic factors could be associated with higher adherence rates to …

Determining The Effects Of Exogenous Human Chorionic Gonadotropin And Pregnant Mare Serum Gonadotropin On Plasma Testosterone, Testicular Volume, And Semen Production In Leopard Geckos (Eublepharis Macularius), Alexandra Mason

LSU Master's Theses

Planet earth has now entered into its sixth mass extinction as a result of expanding human populations, posing an unprecedented threat to biologic diversity. Climate change, habitat fragmentation, wildlife trade, pollution, and biological invasions are just a few consequences of human activities that have directly contributed to unprecedented species extinctions. While widespread amphibian declines have gained more recent attention, it has been proposed that reptiles may be in even greater danger of extinction worldwide. Unfortunately, many reptiles are destined to go extinct before many of their basic biologic traits, including reproductive methods, have even been determined.

In order to mitigate …

Assessing The Validity Of The Estimation Of Population Affinity From The Maxillary Hard Palate: An Empirical Approach Using A Modern Forensic Sample, Christopher M. Goden

LSU Master's Theses

In response to Beathard and DiGangi’s (2020) call to action for empirical assessment of population affinity estimation methodology, this study investigates the validity of maxillary palate shape as an indicator of ancestral population affinity for human skeletal remains through the use of Elliptical Fourier Analysis (EFA) and Linear Discriminant Function Analysis (DFA). Further, this study also places emphasis on the expressed variation of palate shape within and between population groups exemplified by Principal Component Analysis (PCA) of EFA data.

Computed tomography scans of 180 individuals of Black, White, and Hispanic population affinities were obtained from the New Mexico Decedent Imaging …

Modeling Cumulative Risk During The Covid-19 Pandemic: Psychosocial And Socioeconomic Factors For Older Minority Adults, James F. Osborne Iv

LSU Master's Theses

Continued response to the sum consequences of the COVID-19 pandemic has disparately affected the physical and mental health of older minority adults in the United States. SARS-CoV-2 created an acute epidemiological crisis of public health coinciding with a chronic pandemic of accentuated psychosocial stress. Biological and socio-economic risk of morbidity and mortality follow a demographic gradient of subjectively constructed social status that disproportionally threatens older adults and minority racial/ethnic communities. Pathways to increased socio-economic and psychosocial vulnerability are multifactorial and complex. Factors of race, socio-economic status, gender, and age, each contribute to individualized profiles of vulnerability to risk exposure.

The …

Use Of A Zebrafish Model To Identify Anticonvulsant Properties Of Cannabinoid And Terpenoid Extracts And Mixtures, Courtney Murr

LSU Master's Theses

Epilepsy is a complex group of neurological disorders affecting approximately 65 million people worldwide. Animal models reveal the activation of cannabinoid receptor 1 and cannabinoid receptor 2 reduces the severity of seizures associated with epilepsy. Trials of phytocannabinoids in mammals demonstrate their efficacy of reducing the severity of epileptic seizures. Numerous terpenoid compounds are present in Cannabis plants but most have yet to be clinically investigated. The goal of this research was to use zebrafish (Danio rerio) to identify the potential anticonvulsive properties of phytocannabinoid and terpenoid compounds. During acute cannabinoid exposures, 7-days-post-fertilization (7 dpf) zebrafish larvae were …

Characterization Of Memory T-Lymphocyte Subsets In Dogs, Annie Beth Bauman

LSU Master's Theses

A more complete understanding of canine T-cell immunity is necessary for improving diagnostic and therapeutic approaches to canine diseases, developing cell-based canine immunotherapeutics, and evaluating dogs as large mammal models for comparative immunology research. Canine immunological studies are limited by the lack of established phenotypic markers identifying diverse differentiation states in canine T-cells. Differential expression of CD45RA (indicating antigen experience) and CD62L (indicating lymph node homing capability), shows promise as a tool to delineate canine naïve (TN), central memory (TCM), effector memory (TEM), and terminal effector memory (TEMRA) T-cells. The aim of this study was to characterize canine memory T-cell …

Predictive Modeling Of Fmol Health System Utilization Using Machine Learning Algorithms And Retrospective Study Of Covid Tested Patients, Ramyakrishna Tummala

LSU Master's Theses

Overutilization of Emergency Departments (ED) is a major problem among the health care providers in the United States. In this research, a machine learning-based predictive model for predicting ED high utilizers will be designed based on a set of existing and proposed facilities and the population and social determinant of health (SDOH) factors influencing utilization. The purpose of the model will be to alert the healthcare systems and government organizations by identifying the reasons for overutilization of the medical services among the people in a particular community. Also, the novel coronavirus disease 2019 (COVID-19) developed in Whunan city, China has …

Brown's Stages Of Morphosyntactic Development Applied To The Typical Development Of Italian, Marie Laiche

LSU Master's Theses

Background: In A First Language (1973), Roger Brown called for an increase in crosslinguistic data and analysis of morphosyntax across languages as more research in this field is crucial for working out the overarching determinants of language acquisition order and for the ability to accurately compare child language acquisition across different languages. An increase in this research would benefit linguistic researchers and speech-language-pathologists offering services to or evaluating children speaking a different language or more than one language. The current study seeks to add to the field of crosslinguistic research by adapting Brown’s guidelines of English language acquisition to the …