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Current Clinical Approach Of Nosocomial Clostridium Difficileinfection, Frans Liwang, Robert Sinto
Current Clinical Approach Of Nosocomial Clostridium Difficileinfection, Frans Liwang, Robert Sinto
Jurnal Penyakit Dalam Indonesia
Hospital-acquired Clostridium difficile infection (CDI) has become one of the global threats because the incidence has increased in recent decades. This nosocomial infection is closely related to antibiotic use in health services and is commonly found in the elderly. Antibiotics can promote colonization and CDI by intestinal microbiota dysbiosis and complex innate immune system activation. The manifestation also has a wide spectrum, ranging from mild diarrhea to fulminant colonic mucosal necrosis. Given that not all colonized subjects will be infected, further investigations such as toxigenic culture, nucleic-acid detection, and stool immunologic tests are only useful in symptomatic cases. In all …