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A Mini-Review Regarding The Carcinogenesis And Morphology Of Serous Tumors Of The Ovary, Fallopian Tube And Peritoneum, Tiberiu-Augustin Georgescu, Roxana Bohiltea, Octavian Munteanu, Corina Grigoriu, Ioana Paunica, Maria Sajin

Journal of Mind and Medical Sciences

Similar to the already well-recognized adenoma-carcinoma sequence in colorectal cancer pathogenesis, it has been believed for many decades that the progression of ovarian epithelial tumors occurs from benign serous cystadenomas to borderline tumors, to well-differentiated carcinomas, and ultimately, to poorly differentiated carcinomas. However, it is currently accepted that low-grade serous carcinoma (LGSC) and high-grade serous carcinoma (HGSC) are fundamentally different tumor types and, consequently, different diseases. In fact, whereas the benign-borderline-malignant sequence seems to apply quite well to low-grade serous carcinoma, the sequence of genetic alterations in high-grade serous carcinoma is substantially different. In this mini-review, we included the current …