Medicine and Health Sciences Commons^™

Covid-19 In Children: More Than Meets The Eye, Sh F. Hagmann

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No abstract provided.

Febrile Infant: Covid-19 In Addition To The Usual Suspects, E Robbins, Z Ilahi, P Roth

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No abstract provided.

Facing Covid-19 In The Icu: Vascular Dysfunction, Thrombosis, And Dysregulated Inflammation, De Leisman, Cs Deutschman, M Legrand

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No abstract provided.

Pediatric Covid-19-Associated Rhabdomyolysis: A Case Report, Am Gefen, N Palumbo, Sk Nathan, Ps Singer, Lj Castellanos-Reyes, Cb Sethna

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No abstract provided.

Immunotherapies For Covid-19: Lessons Learned From Sepsis, Ke Remy, Sc Brakenridge, B Francois, T Daix, Cs Deutschman, G Monneret, R Jeannet, Pf Laterre, Rs Hotchkiss, Ll Moldawer

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No abstract provided.

Characteristics, Cardiac Involvement, And Outcomes Of Multisystem Inflammatory Disease Of Childhood (Mis-C) Associated With Sars-Cov-2 Infection., Ca Capone, A Subramony, T Sweberg, J Schneider, S Shah, L Rubin, C Schleien, S Epstein, Jc Johnson, A Kessel, N Misra, E Mitchell, N Palumbo, S Rajan, J Rocker, K Williamson, Kw Davidson

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No abstract provided.

Central Apnea In An Adolescent With Covid-19, S Enner, S Hormozdyaran, R Varughese, J Milillo, I Pavkovic, E Laureta, J Schneider, S Kothare

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No abstract provided.

Limiting Hospital Resources For Acute Appendicitis In Children: Lessons Learned From The U.S. Epicenter Of The Covid-19 Pandemic, Cl Kvasnovsky, Y Shi, B S. Rich, R D. Glick, S Z. Soffer, A M. Lipskar, S Dolgin, A Hong, J M. Prince, C Sathya, +2 Additional Authors

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No abstract provided.

Varying Presentations And Favourable Outcomes Of Covid-19 Infection In Children And Young Adults With Sickle Cell Disease: An Additional Case Series With Comparisons To Published Cases., A Appiah-Kubi, S Acharya, C Fein Levy, A Vlachos, G Ostovar, K Murphy, A Farrell, D Brower, Jm Lipton, B Aygun, +1 Additional Authors

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No abstract provided.

A Pediatric Patient With Sickle Cell Disease Presenting With Severe Anemia And Splenic Sequestration In The Setting Of Covid-19, S. Jacob, A. Dworkin, E. Romanos-Sirakis

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No abstract provided.

A Pediatric Infectious Disease Perspective Of Sars-Cov-2 And Covid-19 In Children., A. L. Shane, A. I. Sato, C. Kao, F. C. Adler-Shohet, S. B. Vora, J. Ery, J. Auletta, S. Nachman, M. K. Kainth, K. Kotloff, +15 Additional Authors

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Understanding the role that children play in the clinical burden and propagation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) responsible for novel coronavirus (COVID-19) infections is emerging. While the severe manifestations and acute clinical burden of COVID-19 has largely spared children compared to adults, understanding the epidemiology, clinical presentation, diagnostics, management, and prevention opportunities as well as the social and behavioral impacts on child health is vital. Foremost is clarifying the contribution of asymptomatic and mild infections to transmission within the household and community and the clinical and epidemiologic significance of uncommon severe post-infectious complications. Herein we summarize the …

Cardiac Dysfunction And Shock In Pediatric Patients With Covid-19., K. Joshi, D. Kaplan, A. Bakar, J. F. Jennings, D. A. Hayes, S. Mahajan, N. Misra, E. Mitchell, T. M. Sweberg, M. D. Taylor, C. A. Capone

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Coronavirus disease-2019 (COVID-19) has been reported to cause significant morbidity in adults, with reportedly a lesser impact on children. Cardiac dysfunction has only been described in adults thus far. We describe 3 cases of previously healthy children presenting with shock and COVID-19-related cardiac inflammation. (Level of Difficulty: Intermediate.).

Covid-19 Outcomes In Ms Observational Study Of Early Experience From Nyu Multiple Sclerosis Comprehensive Care Center, E. Parrotta, I. Kister, L. Charvet, C. Sammarco, V. Saha, R. E. Charlson, J. Howard, J. M. Gutman, C. Fernandez-Carbonell, L. Z. Ryerson, +5 Additional Authors

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No abstract provided.

Management Of Neonates After Postpartum Discharge And All Children In The Ambulatory Setting During The Coronavirus Disease 2019 (Covid-19) Pandemic, K. L. Harriel, D. Nolt, S. Moore, S. Kressly, H. H. Bernstein

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PURPOSE OF REVIEW: The present coronavirus disease 2019 (COVID-19) pandemic has created additional challenges with an increased number of presumed healthy, full-term newborns being discharged at 24 h after delivery. Short lengths of stay raise the possibility of mother-infant dyads being less ready for discharge, defined as at least one of the three informants (i.e., mother, pediatrician, and obstetrician) believing that either the mother and/or infant should stay longer than the proposed time of discharge. This public health crisis has reduced the number of in-person well child visits, negatively impacting vaccine receipt, and anticipatory guidance. RECENT FINDINGS: Extra precautions should …

Presentation Of Severe Acute Respiratory Syndrome-Coronavirus 2 Infection As Cholestatic Jaundice In Two Healthy Adolescents, A. Perez, D. Kogan-Liberman, S. Sheflin-Findling, A. Raizner, K. L. Ahuja, N. Ovchinsky

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© 2020 Elsevier Inc. Liver abnormalities in severe acute respiratory syndrome-coronavirus 2 infection, including hepatitis and cholestasis, have been observed in adults and are associated with worse outcomes. We describe 2 adolescents with cholestasis and hepatitis with mild presentation of severe acute respiratory syndrome-coronavirus 2 lacking typical symptoms. Our intention is to raise index of suspicion for testing and protective equipment use.

Role Of A Pediatric Cardiologist In The Covid-19 Pandemic, T. Niaz, K. Hope, M. Fremed, N. Misra, C. Altman, J. Glickstein, J. Sanchez-De-Toledo, A. Fraisse, J. Miller, D. Chowdhury, +2 Additional Authors

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© 2020, Springer Science+Business Media, LLC, part of Springer Nature. Coronavirus disease 2019 (COVID-19) has affected patients across all age groups, with a wide range of illness severity from asymptomatic carriers to severe multi-organ dysfunction and death. Although early reports have shown that younger age groups experience less severe disease than older adults, our understanding of this phenomenon is in continuous evolution. Recently, a severe multisystem inflammatory syndrome in children (MIS-C), with active or recent COVID-19 infection, has been increasingly reported. Children with MIS-C may demonstrate signs and symptoms of Kawasaki disease, but also have some distinct differences. These children …

Severe Coronavirus Disease 2019 Infection In An Adolescent Patient After Hematopoietic Stem Cell Transplantation, G. Fisler, A. Haimed, C. F. Levy, J. Stiles, C. A. Capone, J. D. Fish, J. A. Brochstein, M. D. Taylor

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© 2020 American College of Chest Physicians Infection with the severe acute respiratory syndrome coronavirus 2 causes severe acute lung injury in approximately 5% of infected adults, but few reports have been made of severe pediatric disease. We present an adolescent patient who contracted severe acute respiratory syndrome coronavirus 2 one week after a paternal haplo-identical hematopoietic stem cell transplant, with development of severe hyperferritinemic acute lung injury and macrophage activation-like syndrome. We present her case and a comparison of her laboratory data with those of a cohort of pediatric patients with coronavirus disease 2019 without severe disease.

The Crisis Close At Hand: How Covid-19 Challenges Long-Term Care Planning For Adults With Intellectual Disability, C. Wright, C. Steinway, S. Jan

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© 2020 Charmaine Wright et al. Published by Mary Ann Liebert, Inc. Whether cared for in the community or in a facility, adults with intellectual disability are among the most vulnerable individuals in the United States. Families caring for these individuals face financial, social, and emotional stress as they navigate long-term care choices for their loved ones. COVID-19 has stressed an already overwhelmed and disparate system.

Comparison Of Clinical And Epidemiologic Characteristics Of Young Febrile Infants With And Without Sars-Cov-2 Infection., J. Leibowitz, W. Krief, S. Barone, K. A. Williamson, P. Goenka, S. Rai, S. Moriarty, P. Baodhankar, L. G. Rubin

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OBJECTIVE: To determine features that distinguish febrile young infants with SARS-CoV-2 infection.

STUDY DESIGN: Retrospective single-center study included febrile infantsChildren's Medical Center of Northwell Health, New Hyde Park, New York during March 1-April 30 of 2018, 2019, and 2020. Sociodemographic and clinical features were compared between those seen during the 2020 COVID-19 pandemic and previous years, as well as between SARS-CoV-2 infected infants and SARS-CoV-2 uninfected infants (SARS-CoV-2 negative or evaluated during 2018 and 2019).

RESULTS: In all, 124 febrile infantsidentified; 38 during the 2-month study period in 2018, 33 in 2019, and 53 in 2020. During 2020, fewer febrile …

Are Children With Sars-Cov-2 Infection At High Risk For Thrombosis? Viscoelastic Testing And Coagulation Profiles In A Case Series Of Pediatric Patients, M. Al-Ghafry, B. Aygun, A. Appiah-Kubi, A. Vlachos, G. Ostovar, C. Capone, T. Sweberg, N. Palumbo, P. Goenka, L. L. Wolfe, J. M. Lipton, S. S. Acharya

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© 2020 Wiley Periodicals LLC The coagulopathy of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is well documented in adults, with increases in D-dimer and prothrombin time found to be strong predictors of mortality, and anticoagulation shown to decrease this mortality. Viscoelastic parameters such as elevations in maximum clot firmness (MCF) on rotational thromboelastometry (ROTEM) have correlated with a hypercoagulable state in adults with SARS-CoV-2. We report our experience in children infected with SARS-CoV-2, with noted elevations in D-dimer and MCF on ROTEM (indicating hypercoagulability). Exploration of viscoelastic testing to provide additional laboratory-based evidence for pediatric-specific risk assessment …

Reporting Of Child Maltreatment During The Sars-Cov-2 Pandemic In New York City From March To May 2020, E. Rapoport, H. Reisert, E. Schoeman, A. Adesman

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© 2020 Elsevier Ltd Background: School closures and other public health responses have decreased the extent that children interact with mandated reporters and other professionals trained to detect child maltreatment. Objective: To assess associations between the pandemic public health response and the number of allegations of child abuse or neglect. Methods: This study analyzed monthly data from New York City of the number of child maltreatment allegations, stratified by reporter type (e.g., mandated reporter, education personnel, healthcare personnel), as well as the number of Child Protective Services (CPS) investigations warranting child welfare preventative services. SARIMA models were trained using data …

Cytokine Elevation In Severe And Critical Covid-19: A Rapid Systematic Review, Meta-Analysis, And Comparison With Other Inflammatory Syndromes., D. E. Leisman, L. Ronner, R. Pinotti, M. D. Taylor, P. Sinha, C. S. Calfee, A. V. Hirayama, F. Mastroiani, C. J. Turtle, C. S. Deutschman, +2 Additional Authors

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The description of a so-called cytokine storm in patients with COVID-19 has prompted consideration of anti-cytokine therapies, particularly interleukin-6 antagonists. However, direct systematic comparisons of COVID-19 with other critical illnesses associated with elevated cytokine concentrations have not been reported. In this Rapid Review, we report the results of a systematic review and meta-analysis of COVID-19 studies published or posted as preprints between Nov 1, 2019, and April 14, 2020, in which interleukin-6 concentrations in patients with severe or critical disease were recorded. 25 COVID-19 studies (n=1245 patients) were ultimately included. Comparator groups included four trials each in sepsis (n=5320), cytokine …

Characteristics And Risk Factors Associated With Critical Illness In Pediatric Covid-19, G. Fisler, S. M. Izard, S. Shah, D. Lewis, M. K. Kainth, S. H. F. Hagmann, J. A. Belfer, L. M. Feld, F. Mastroianni, C. L. Kvasnovsky, C. A. Capone, J. Schneider, T. Sweberg, C. Schleien, M. D. Taylor

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© 2020, The Author(s). Background: While much has been reported regarding the clinical course of COVID-19 in children, little is known regarding factors associated with organ dysfunction in pediatric COVID-19. We describe critical illness in pediatric patients with active COVID-19 and identify factors associated with PICU admission and organ dysfunction. This is a retrospective chart review of 77 pediatric patients age 1 day to 21 years admitted to two New York City pediatric hospitals within the Northwell Health system between February 1 and April 24, 2020 with PCR + SARS-CoV-2. Descriptive statistics were used to describe the hospital course and …

Clinical Characteristics And Outcomes Of Critically Ill Patients With Covid-19 Admitted To An Intensive Care Unit In London: A Prospective Observational Cohort Study, R. J. Thomson, J. Hunter, J. Dutton, J. Schneider, M. Khosravi, A. Casement, K. Dhadwal, D. Martin

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© 2020 Thomson et al. Background Cohorts of severely ill patients with COVID-19 have been described in several countries around the globe, but to date there have been few published reports from the United Kingdom (UK). Understanding the characteristics of the affected population admitted to intensive care units (ICUs) in the UK is crucial to inform clinical decision making, research and planning for future waves of infection. Methods We conducted a prospective observational cohort study of all patients with COVID-19 admitted to a large UK ICU from March to May 2020 with follow-up to June 2020. Data were collected from …

A Primer On A Comprehensive Genetic Approach To Vascular Anomalies, A. J. Borst, T. A. Nakano, F. Blei, D. M. Adams, J. Duis

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No abstract provided.

Adolescent Sjogren's Syndrome Presenting As Psychosis: A Case Series, E. K. Hammett, C. Fernandez-Carbonell, C. Crayne, A. Boneparth, R. Q. Cron, S. M. Radhakrishna

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No abstract provided.

A Modified Delphi Study To Prioritize Content For A Simulation-Based Pediatric Curriculum For Emergency Medicine Residency Training Programs, J. Mitzman, I. Bank, R. A. Burns, M. C. Nguyen, P. Zaveri, M. J. Falk, M. Madhok, A. Dietrich, F. M. Bullaro, M. Auerbach, +9 Additional Authors

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© 2019 by the Society for Academic Emergency Medicine Objectives: Pediatric training is an essential component of emergency medicine (EM) residency. The heterogeneity of pediatric experiences poses a significant challenge to training programs. A national simulation curriculum can assist in providing a standardized foundation of pediatric training experience to all EM trainees. Previously, a consensus-derived set of content for a pediatric curriculum for EM was published. This study aimed to prioritize that content to establish a pediatric simulation-based curriculum for all EM residency programs. Methods: Seventy-three participants were recruited to participate in a three-round modified Delphi project from 10 stakeholder …

Altered Monocyte And Langerhans Cell Innate Immunity In Patients With Recurrent Respiratory Papillomatosis (Rrp), M. Israr, J. A. Devoti, F. Lam, A. L. Abramson, B. M. Steinberg, V. R. Bonagura

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No abstract provided.

A Quality Improvement Project To Standardize Surfactant Delivery In The Era Of Noninvasive Ventilation., J. E. Kim, M. Brewer, R. Spinazzola, E. Wallace, J. Casatelli, J. Beachy, B. Weinberger, S. Perveen

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No abstract provided.

Brucella Exposure Risk Events In 10 Clinical Laboratories, New York City, Usa, 2015 To 2017, J. Ackelsberg, A. Liddicoat, T. Burke, W. A. Szymczak, M. H. Levi, B. Ostrowsky, E. A. Mitchell, W. Lowe, R. Khare, M. Layton, +34 Additional Authors

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Copyright © 2020 American Society for Microbiology. All Rights Reserved. From 2015 to 2017, 11 confirmed brucellosis cases were reported in New York City, leading to 10 Brucella exposure risk events (Brucella events) in 7 clinical laboratories (CLs). Most patients had traveled to countries where brucellosis is endemic and presented with histories and findings consistent with brucellosis. CLs were not notified that specimens might yield a hazardous organism, as the clinicians did not consider brucellosis until they were notified that bacteremia with Brucella was suspected. In 3 Brucella events, the CLs did not suspect that slow-growing, small Gram-negative bacteria might …