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- Blood pressure (9)
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- Stress (5)
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- Central nervous system (2)
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Articles 1 - 17 of 17
Full-Text Articles in Medicine and Health Sciences
Blood Pressure Increases During A Simulated Night Shift In Persons At Risk For Hypertension, James A. Mccubbin, June J. Pilcher, D Dewayne Moore
Blood Pressure Increases During A Simulated Night Shift In Persons At Risk For Hypertension, James A. Mccubbin, June J. Pilcher, D Dewayne Moore
James A. McCubbin
Background: Shift work with sleep disruption is a systemic stressor that may possibly be associated with blood pressure dsyregulation and hypertension. Purpose: We hypothesize that rotation to a simulated night shift with sleep deprivation will produce blood pressure elevations in persons at risk for development of hypertension. Method: We examined the effects of a simulated night shift on resting blood pressure in 51 diurnal young adults without current hypertension. Resting blood pressure was monitored throughout a 24 hour period of total sleep deprivation with sustained cognitive work. Twelve participants (23.5%) reported one or more parents with a diagnosis of hypertension. …
Does Gender Affect The Relation Between Blood Pressure And Pain Sensitivity?, James A. Mccubbin, Suzanne G. Helfer
Does Gender Affect The Relation Between Blood Pressure And Pain Sensitivity?, James A. Mccubbin, Suzanne G. Helfer
James A. McCubbin
High resting blood pressure is associated with decreased pain sensitivity. This study was designed to explore this relation in young, normotensive men and women. Twenty-nine women (mean age 19.1, range 18–29) and 26 men (mean age 19.3, range 18–25) rested for 10 min while systolic, diastolic, and mean arterial blood pressures were measured. They were then asked to complete a 2-min cold pressor task. Participants were asked to fill out the short form of the McGill Pain Questionnaire immediately after the pain task. Hierarchical regression analyses were performed to predict pain sensitivity from resting blood pressure, gender, and the interaction …
Blood Pressure Control And Hormone Replacement Therapy In Postmenopausal Women At Risk For Coronary Heart Disease, James A. Mccubbin, Suzanne G. Helfer, Fred S. Switzer Iii, Thomas M. Price
Blood Pressure Control And Hormone Replacement Therapy In Postmenopausal Women At Risk For Coronary Heart Disease, James A. Mccubbin, Suzanne G. Helfer, Fred S. Switzer Iii, Thomas M. Price
James A. McCubbin
Coronary Heart Disease (CHD) in women is strongly associated with estrogen deprivation. For example, risk for CHD increases dramatically after menopause, however the role of hormone replacement therapy in CHD prevention is currently unresolved. In order to better understand CHD in women, the precise mechanisms by which estrogen affects circulatory function require clarification. Evidence suggests that exogenous estrogen may affect blood pressure control, but its interaction with other CHD risk factors has not been systematically characterized. The present study examines the role of mildly elevated resting blood pressure, family history of CHD and hormone replacement on blood pressure responses to …
Decreased Cognitive/Cns Function In Young Adults At Risk For Hypertension: Effects Of Sleep Deprivation, James A. Mccubbin, Hannah Peach, Dewayne D. Moore, June J. Pilcher
Decreased Cognitive/Cns Function In Young Adults At Risk For Hypertension: Effects Of Sleep Deprivation, James A. Mccubbin, Hannah Peach, Dewayne D. Moore, June J. Pilcher
James A. McCubbin
Hypertension has been linked to impaired cognitive/CNS function, and some of these changes may precede development of frank essential hypertension. The stress and fatigue of sleep deprivation may exacerbate these cognitive changes in young adults at risk. We hypothesize that individuals at risk for hypertension will show significant declines in cognitive function during a night of sleep deprivation. Fifty-one young adults were recruited for 28-hour total sleep deprivation studies. Hypertension risk was assessed by mildly elevated resting blood pressure and by family history of hypertension. A series of cognitive memory tasks was given at four test sessions across the sleep …
Coping Styles, Opioid Blockade, And Cardiovascular Response To Stress, Stephen Bruehl, James Mccubbin, John Wilson, Thomas Montgomery, Paloma Ibarra, Charles Carlson
Coping Styles, Opioid Blockade, And Cardiovascular Response To Stress, Stephen Bruehl, James Mccubbin, John Wilson, Thomas Montgomery, Paloma Ibarra, Charles Carlson
James A. McCubbin
We investigated the hypothesis that the effects of Monitoring and Blunting coping styles are mediated in part by endogenous opioids. Mean arterial pressure (MAP) and heart rate (HR) were measured in 39 males before, during, and after a mental arithmetic stressor. Each subject experienced the protocol once under opioid blockade (naltrexone) and once in a placebo condition, in counterbalanced order. Monitoring and Blunting were assessed using the Miller Behavioral Style Scale. High Blunting and high Monitoring were both associated with poorer MAP recovery under opioid blockade than in the placebo condition. Similar effects were noted for Blunting on the measure …
Relaxation Training And Opioid Inhibition Of Blood Pressure Response To Stress, James Mccubbin, John Wilson, Stephen Bruehl, Paloma Ibarra, Charles Carlson, Jane Norton, George Colclough
Relaxation Training And Opioid Inhibition Of Blood Pressure Response To Stress, James Mccubbin, John Wilson, Stephen Bruehl, Paloma Ibarra, Charles Carlson, Jane Norton, George Colclough
James A. McCubbin
The present study was designed to determine the role of endogenous opioid mechanisms in the circulatory effects of relaxation training. Opioid mechanisms were assessed by examination of the effects of opioid receptor blockade with naltrexone on acute cardiovascular reactivity to laboratory stress before and after relaxation training. 32 young men with mildly elevated casual arterial pressure were recruited for placebo-controlled naltrexone stress tests and relaxation training. The results indicated that relaxation training significantly reduced the diastolic pressure response to mental arithmetic stress. Opioid receptor blockade with naltrexone antagonized the effects of relaxation training. These findings suggest that some of the …
Effects Of Estrogen And Opioid Blockade On Blood Pressure Reactivity To Stress In Postmenopausal Women, James Mccubbin, Allyssa Allen, James Loveless, Suzanne Helfer
Effects Of Estrogen And Opioid Blockade On Blood Pressure Reactivity To Stress In Postmenopausal Women, James Mccubbin, Allyssa Allen, James Loveless, Suzanne Helfer
James A. McCubbin
Estrogen may influence coronary heart disease risk in women through the effects of endogenous opioids on autonomic control of blood pressure. In a randomized, placebo-controlled trial, we examined the combined effects of estrogen and the opioid antagonist, naltrexone, on blood pressure responses to psychological stress in 42 postmenopausal women. After 3 months of estrogen or estrogen plus progestin (hormone replacement therapy; n = 27) or placebo replacement, participants completed a mental arithmetic task after administration of .7 mg/kg oral naltrexone or placebo. Systolic blood pressure (SBP), diastolic blood pressure, mean arterial pressure and heart rate (HR) were measured at rest …
Emotional Dampening In Persons With Elevated Blood Pressure: Affect Dysregulation And Risk For Hypertension, James Mccubbin, J Loveless, J Graham, D Moore, G Hall, R Bart, M Merritt, R Lane, J Thayer
Emotional Dampening In Persons With Elevated Blood Pressure: Affect Dysregulation And Risk For Hypertension, James Mccubbin, J Loveless, J Graham, D Moore, G Hall, R Bart, M Merritt, R Lane, J Thayer
James A. McCubbin
Background Persons with higher blood pressure have emotional dampening in some contexts. This may reflect interactive changes in central nervous system control of affect and autonomic function in the early stages of hypertension development. Purpose The purpose of this study is to determine the independence of cardiovascular emotional dampening from alexithymia to better understand the role of affect dysregulation in blood pressure elevations. Methods Ninety-six normotensives were assessed for resting systolic and diastolic (DBP) blood pressure, recognition of emotions in faces and sentences using the Perception of Affect Task (PAT), alexithymia, anxiety, and defensiveness. Results Resting DBP significantly predicted PAT …
Two Brief Interventions For Acute Pain, Stephen Bruehl, Charles Carlson, James Mccubbin
Two Brief Interventions For Acute Pain, Stephen Bruehl, Charles Carlson, James Mccubbin
James A. McCubbin
This study evaluated two brief (3–5 min) interventions for controlling responses to acute pain. Eighty male subjects were randomly assigned to 1 of 2 intervention groups (Positive Emotion Induction (PEI) or Brief Relaxation (BR)) or to 1 of 2 control groups (No-instruction or Social Demand). The PEI focused on re-creating a pleasant memory, while the BR procedure involved decreasing respiration rate and positioning the body in a relaxed posture. All subjects underwent a 60-sec finger pressure pain trial. Analyses indicated that the PEI subjects reported lower ratings of pain, fear, and anxiety, and experienced greater finger temperature recovery than controls. …
Psychological Coping With Acute Pain: An Examination Of The Role Of Endogenous Opioid Mechanisms, Stephen Bruehl, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman, James Mccubbin
Psychological Coping With Acute Pain: An Examination Of The Role Of Endogenous Opioid Mechanisms, Stephen Bruehl, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman, James Mccubbin
James A. McCubbin
This study examined the relationship among endogenous opioids, Monitoring and Blunting coping styles, and acute pain responses. Fifty-eight male subjects underwent a 1-min pressure pain stimulus during two laboratory sessions. Subjects experienced this pain stimulus once under endogenous opioid blockade with naltrexone and once in a placebo condition. Blunting was found to be negatively correlated with pain ratings, but this relationship was significantly more prominent under opioid blockade. Results for coping behaviors subjects used to manage the experimental pain were generally consistent with the Blunting results, indicating that cognitive coping was related more strongly to decreased pain ratings and cardiovascular …
The Psychobiology Of Hostility: Possible Endogenous Opioid Mechanisms, Stephen Bruehl, James Mccubbin, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman
The Psychobiology Of Hostility: Possible Endogenous Opioid Mechanisms, Stephen Bruehl, James Mccubbin, Charles Carlson, John Wilson, Jane Norton, George Colclough, Marianne Brady, Jeffrey Sherman
James A. McCubbin
This study examined the role of endogenous opioids in the relation between hostility and cardiovascular stress responsiveness. Forty-six mencompleted the Cook-Medley Hostility Scale, and experienced a laboratory pain stressor once under opioid blockade and once under placebo. Hostility scores were significantly related to the magnitude of change in cardiovascular reactivity/recovery resulting from opioid blockade. Low scorers on the Cynicism subscalc displayed increases in heart rate (HR) reactivity under blockade relative to placebo, with reactivity decreases noted in high scorers. Low Hostile Affect scores were similarly associated with impaired diastolic blood pressure recovery under opioid blockade. HR recovery results were somewhat …
The Relationship Between Pain Sensitivity And Blood Pressure In Normotensives, Stephen Bruehl, Charles Carlson, James Mccubbin
The Relationship Between Pain Sensitivity And Blood Pressure In Normotensives, Stephen Bruehl, Charles Carlson, James Mccubbin
James A. McCubbin
Hypertension has been found to be related to decreased sensitivity to painful stimuli. The current study explored whether this relationship extends into the normotensive range of blood pressures. Resting blood pressures were assessed in 60 male normotensives. Subjects then underwent a l min finger pressure pain stimulation trial. Pain ratings were inversely related to resting systolic blood pressure. This relationship was unrelated to emotional state or coping styles. Multiple regression analyses indicated that over one-third of the variance in pain ratings can be accounted for by resting blood pressure, coping style, and emotional state.
Cardiovascular Emotional Dampening: The Relationship Between Blood Pressure And Recognition Of Emotion, James A. Mccubbin, Marcellus M. Merritt, John J. Sollers Iii, Michele K. Evans, Alan B. Zonderman, Richard D. Lane, Julian F. Thayer
Cardiovascular Emotional Dampening: The Relationship Between Blood Pressure And Recognition Of Emotion, James A. Mccubbin, Marcellus M. Merritt, John J. Sollers Iii, Michele K. Evans, Alan B. Zonderman, Richard D. Lane, Julian F. Thayer
James A. McCubbin
Objective—Persons with elevated blood pressure show dampened emotional responses to affectladen stimuli. We sought to further examine cardiovascular emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African-American community-based sample. Methods—Participants were 106 African American men and women (55 female; mean age 52.8 years), mainly low in socioeconomic status and part of the Healthy Aging in Nationally Diverse Longitudinal Samples (HANDLS-Pilot) Pilot Study. Participants evaluated emotional expressions in faces and in sentences using the Perception of Affect Test (PAT). Resting blood pressure, total peripheral resistance (TPR), cardiac output and heart rate were …
Endogenous Opiate Peptides, Stress Reactivity, And Risk For Hypertension, James Mccubbin, Richard Surwit, Redford Williams
Endogenous Opiate Peptides, Stress Reactivity, And Risk For Hypertension, James Mccubbin, Richard Surwit, Redford Williams
James A. McCubbin
Endogenous opiate peptides can regulate neuroendocrine and circulatory responses to behavioral stress and may be important in the pathogenic effects of sympathoadrenal reactivity. We tested this hypothesis by examining the effect of the opiate antagonist naloxone on blood pressure responses to behavioral stress in young adults with high, medium, or low casual blood pressures. Naloxone increased mean arterial pressure responses to stress in subjects with low casual pressure, but had no significant effect on responses in subjects with high casual pressure. These results suggest opioidergic inhibition of sympathetic nervous system responses may be deficient in persons at risk for essential …
An Unusual Reaction To Opioid Blockade With Naltrexone In A Case Of Posttraumatic Stress Disorder, Paloma Ibarra, Stephen P. Bruehl, James A. Mccubbin, Charles R. Carlson, John F. Wilson, Jane A. Norton, Thomas B. Montgomery
An Unusual Reaction To Opioid Blockade With Naltrexone In A Case Of Posttraumatic Stress Disorder, Paloma Ibarra, Stephen P. Bruehl, James A. Mccubbin, Charles R. Carlson, John F. Wilson, Jane A. Norton, Thomas B. Montgomery
James A. McCubbin
An unusual behavioral and cardiovascular reaction was observed during opioid blockade with naltrexone in a 32-year-old male who met DSM III-R criteria for post-traumatic stress disorder (PTSD). As part of an ongoing placebo-controlled investigation of the effects of naltrexone on laboratory and ambulatory blood pressure reactivity, this participant reported experiencing feelings of rage, explosive behavior, and other unpleasant symptoms. When compared to all other subjects (N=24), this individual showed significantly greater effects of naltrexone on blood pressure reactivity during the laboratory stressor. His ambulatory blood pressures, when compared to placebo, were significantly increased during the 24-hr period following naltrexone. The …
Effects Of Stretch-Based Progressive Relaxation Training On The Secretion Of Salivary Immunoglobulin A In Orofacial Pain Patients, Jeffrey Sherman, Charles Carlson, James Mccubbin, John Wilson
Effects Of Stretch-Based Progressive Relaxation Training On The Secretion Of Salivary Immunoglobulin A In Orofacial Pain Patients, Jeffrey Sherman, Charles Carlson, James Mccubbin, John Wilson
James A. McCubbin
There is a growing body of evidence that psychologic stressors can affect physical health and proneness to disease through depletion of the body's immune system. Relatively little research, however, has investigated the potential immunoenhancing effect of stress-relieving strategies such as progressive muscle relaxation. This study explored the relationship between immune functioning and relaxation training with persons experiencing persistent facial pain. In a single experimental session, 21 subjects either received relaxation training or rested for an equivalent time period. Salivary immunoglobulin A, mood, pain, and tension levels were measured before and after relaxation and rest periods. Results indicated that a greater …
Altered Pituitary Hormone Response To Naloxone In Hypertension Development, James Mccubbin, R Surwit, Redford Williams, Charles Nemeroff, Maya Mcneilly
Altered Pituitary Hormone Response To Naloxone In Hypertension Development, James Mccubbin, R Surwit, Redford Williams, Charles Nemeroff, Maya Mcneilly
James A. McCubbin
Endogenous opioid regulation of blood pressure is altered during stress in young adults at risk for hypertension. We studied the effects of the opioid antagonist naloxone on the secretion of corticotropin and B-endorphin during psychological stress in young adults with mildly elevated casual arterial pressures. Naloxone-induced secretion of both corticotropin and B-endorphin was significantly diminished in persons at risk for hypertension compared with the low blood pressure control group. Results suggest that opioidergic inihibition of anterior pituitary function is altered in hypertension development.