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Full-Text Articles in Medicine and Health Sciences
Short-Term Cd8+ T Cell Depletion Results In Blunted Liver Inflammation In Old Mice, Konner J. Terrebonne, David J. Buckley, Blessy Joseph, Sunita Sharma, Daniel W. Trott
Short-Term Cd8+ T Cell Depletion Results In Blunted Liver Inflammation In Old Mice, Konner J. Terrebonne, David J. Buckley, Blessy Joseph, Sunita Sharma, Daniel W. Trott
International Journal of Exercise Science: Conference Proceedings
Advanced age is associated with an increase in basal inflammation of the organs. Previously we have found that T cells accumulate in the liver of old mice. A large proportion of these cells are CD8+ and produce inflammatory cytokines. We have previously demonstrated that CD8+ T cell depletion results in improved glucose tolerance in old mice. However, the mechanisms by which CD8+ depletion improves glucose tolerance is unclear. Therefore, we sought to determine whether pharmacologic CD8+ depletion would result in decreased liver specific inflammation in old mice compared to their old CD8+ intact counterparts. PURPOSE: To test the hypothesis …
Role Of Ghrelin Receptor In Sarcopenia: Involvement Of Redox Signaling And Rankl., Mariam A. Othman, Joo Hyun Kim, Khaled Moustfa, John Lawler
Role Of Ghrelin Receptor In Sarcopenia: Involvement Of Redox Signaling And Rankl., Mariam A. Othman, Joo Hyun Kim, Khaled Moustfa, John Lawler
International Journal of Exercise Science: Conference Proceedings
Sarcopenia is aging-induced debilitating loss of skeletal muscle strength and function. Evidence from aging research suggests an integration of disrupted mechanotransduction and oxidative stress elevation that leads to muscle atrophy. Ghrelin is a 28 amino acid peptide hormone circulating in both acylated (AG) and unacylated (UAG) forms that acts as a nutrient sensor and metabolic regulator. Acylated ghrelin then binds to the growth hormone secretagogue receptor (GHS-R) or the “ghrelin receptor.” Emerging evidence indicates that GHS-R knockout may hold greater promise in protecting against sarcopenia and fasting-induced atrophy (Wu 2020, Sun 2020). Furthermore, ghrelin can promote the elevation of nNOS, …
Age-Related Changes In Skeletal Muscle Oxygen Utilization: A Review, Maxwell T. Aiken, Sabrina S. Salvatore, Kyle N. Zelenski, Ryan K. Perkins
Age-Related Changes In Skeletal Muscle Oxygen Utilization: A Review, Maxwell T. Aiken, Sabrina S. Salvatore, Kyle N. Zelenski, Ryan K. Perkins
International Journal of Exercise Science: Conference Proceedings
The cardiovascular and skeletal muscle systems are intrinsically interconnected, sharing the goal of delivering oxygen to metabolically active tissue. Deficiencies within those systems that affect oxygen delivery to working tissues are a hallmark of advancing age. Oxygen delivery and utilization are reflected as muscle oxygen saturation (SmO2) and may be assessed using near-infrared resonance spectroscopy (NIRS). PURPOSE: This review is intended to provide an update on the current state of literature regarding age-related effects on SmO2. Furthermore, we attempt to bridge the gap between SmO2 and associated underlying mechanisms affected by aging. FINDINGS: SmO …
Macrophage Response To Damage In Old And Young Skeletal Muscle, Jack Mehling, Robert D. Hyldahl, Mohadeseh Ahmadi
Macrophage Response To Damage In Old And Young Skeletal Muscle, Jack Mehling, Robert D. Hyldahl, Mohadeseh Ahmadi
International Journal of Exercise Science: Conference Proceedings
PURPOSE: In skeletal muscle, macrophages migrate to damaged fibers, influencing the inflammatory response during muscle regeneration. Macrophages experience polarization, exhibiting different phenotypes described as M1 (pro-inflammatory) and M2 (anti-inflammatory.) Failure to properly transition between phenotypes inhibits fiber regeneration. Previous animal literature suggests that dysregulated macrophage polarization may contribute to the decreased regenerative capacity of aging muscle. The purpose of this study is to quantify macrophage response and polarization in a model of muscle damage and regeneration in older humans. We hypothesized that older people would have a higher percentage of M2 macrophages relative to the young. METHODS: Seven …
Are Age-Related Differences In Critical Power And Work-Prime Simply Due To Differences In Muscle Mass, Abigail Dorff
Are Age-Related Differences In Critical Power And Work-Prime Simply Due To Differences In Muscle Mass, Abigail Dorff
International Journal of Exercise Science: Conference Proceedings
Critical Power (CP) represents the threshold between sustainable, steady-state and unsustainable, non-steady-state exercise while Work Prime (W’) represents tolerable work above CP. The combination of CP and W’ potently influence exercise tolerance. We recently observed age-related reductions in both CP and W’ in active adults. Age-related decreases in muscle mass, which was not measured, could account for the reduction in CP and W’. PURPOSE: The aim of this study was to determine if CP and W’ are decreased in active, older adults when normalizing for muscle mass. METHODS: Single leg knee extension exercise was used to determine CP …
The Effect Of Acute And Chronic Thermotherapy On Type 2 Diabetic Skeletal Muscle Cell Viability And Gene Expression: Pilot Study, Louay Bachnak, Jean Sparks, Xavier F. Gonzales, Daniel Newmire, Felix Omoruyi
The Effect Of Acute And Chronic Thermotherapy On Type 2 Diabetic Skeletal Muscle Cell Viability And Gene Expression: Pilot Study, Louay Bachnak, Jean Sparks, Xavier F. Gonzales, Daniel Newmire, Felix Omoruyi
International Journal of Exercise Science: Conference Proceedings
Diabetes is a chronic metabolic disease affecting millions of people globally. Type 2 diabetes is associated with insulin resistance or a defective secretion of insulin from the pancreas. The skeletal muscle system accounts for 80% of glucose uptake and is a vital player in healthy aging and muscle mass maintenance. PURPOSE: The purpose of this study was to investigate the effects of thermotherapy on gene expression and cell viability in Type 2 Diabetic skeletal muscle. METHODS: Human skeletal muscle myoblast (HSMM) and Diabetic Type 2 human skeletal muscle myoblast (D-HSMM) (Lonza Inc, Walkersville, MD) were cultured until 90% confluency was, …
Exploring The Role Of Bmp7 Gene Expression In An In Vitro Model Of Aging Human Skeletal Muscle., Dreanna M. Mcadams, Emily L. Zumbro, Chase M. White, Ryan A. Gordon, Anthony A. Duplanty
Exploring The Role Of Bmp7 Gene Expression In An In Vitro Model Of Aging Human Skeletal Muscle., Dreanna M. Mcadams, Emily L. Zumbro, Chase M. White, Ryan A. Gordon, Anthony A. Duplanty
International Journal of Exercise Science: Conference Proceedings
Sarcopenia is an age-related condition associated with rapid loss of skeletal muscle (SKM) tissue that affects mobility and quality of life of geriatric individuals. Mechanistic Target of Rapamycin (mTOR) and Protein Kinase B (AKT) have significant roles in SKM hypertrophy with responses to DNA damage and repair within SKM. However, mTOR and AKT expression is significantly decreased with age. Upstream of AKT, Bone Morphogenetic Protein (BMP7) is a member of the TGF-β signaling family that has been reported as a positive regulator of muscle hypertrophy through the Bmp–Smad1/5/8 signaling axis. PURPOSE: To use an in vitro model of aging …
Improvement In Physical Function And Quality Of Life In Older Adults Following 4 Weeks Of Neuromuscular Electrical Stimulation, Monica A. Mendoza, Mitchell S. Kane, Nigel C. Jiwan, Kyndall P. Ramirez, Lindsay E. Kipp Ph.D, Joni A. Mettler Ph.D
Improvement In Physical Function And Quality Of Life In Older Adults Following 4 Weeks Of Neuromuscular Electrical Stimulation, Monica A. Mendoza, Mitchell S. Kane, Nigel C. Jiwan, Kyndall P. Ramirez, Lindsay E. Kipp Ph.D, Joni A. Mettler Ph.D
International Journal of Exercise Science: Conference Proceedings
Older adults often suffer from sarcopenia, the age-related loss of muscle mass and strength, which negatively impacts physical function and quality of life (QoL). Neuromuscular electrical stimulation (NMES) is frequently used in physical rehabilitation as a muscle strengthening modality; however, little research exists on QoL outcomes in response to NMES. PURPOSE: The aim of this study was to determine changes in QoL and physical function in older adults after 4 weeks of NMES. METHODS: Ten healthy, older adults participated in the study (67.8 ± 2.1 years-old). Each participant was seated on an isokinetic dynamometer with the knee positioned at 60°, …
Exercise In Aging: Can Handgrip Training Improve Skeletal Muscle Oxidative Recovery Kinetics?, Susie Chung, Ryan Rosenberry 2450189, Paul Bhella, Michael Nelson
Exercise In Aging: Can Handgrip Training Improve Skeletal Muscle Oxidative Recovery Kinetics?, Susie Chung, Ryan Rosenberry 2450189, Paul Bhella, Michael Nelson
International Journal of Exercise Science: Conference Proceedings
Loss of skeletal muscle function is a key factor contributing to reduced mobility and quality of life in aging individuals. While the exact mechanism remains unclear, impaired skeletal muscle oxidative capacity has been shown to play a major role. Exercise training increases oxidative capacity early in life; however, the potential for exercise to improve oxidative capacity later in life remains equivocal. PURPOSE: To test the hypothesis that 4 weeks of exercise training can improve skeletal muscle oxidative capacity in elderly individuals beyond the 6th decade of life. METHODS: To-date, 4 community-dwelling seniors from the local Dallas-Fort Worth …
Stress Testing For Diastolic Dysfunction: An Old Approach To A New Question, T. Jake Samuel, Rhys Beaudry, Mark J. Haykowsky, Satyam Sarma, Michael D. Nelson
Stress Testing For Diastolic Dysfunction: An Old Approach To A New Question, T. Jake Samuel, Rhys Beaudry, Mark J. Haykowsky, Satyam Sarma, Michael D. Nelson
International Journal of Exercise Science: Conference Proceedings
BACKGROUND: Currently, conventional cycle echocardiography is the recommended method for diagnosing diastolic dysfunction in patients with unexplained dyspnea upon exertion. However, this method has several underlying limitations including movement and respiratory artifact. These limitations are often exaggerated in patients who are obese and suffer from exertional dyspnea, and therefore limit its application in clinical diagnosis. Our group recently demonstrated that isometric handgrip echocardiography is a powerful sub-clinical diastolic discriminator that avoids the limitations of conventional cycle echocardiography and that can be easily implemented in the clinic. PURPOSE: However, to date it remains unclear how these two methodologies compare, and thus …