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Internal Medicine Publications
NON-B-HEPATITIS; NON-A; SUSTAINED RESPONSE; ALPHA THERAPY; VIRUS-RNA; FOLLOW-UP; HCV RNA; TRIAL; RETREATMENT; METAANALYSIS
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Full-Text Articles in Medicine and Health Sciences
Interferon Alfa-2b Alone Or In Combination With Ribavirin For The Treatment Of Relapse Of Chronic Hepatitis C, Gary L. Davis , M.D., Rafael Esteban-Mur , M.D., Vinod Rustgi , M.D., John Hoefs , M.D., Stuart C. Gordon , M.D., Christian Trepo , M.D., Mitchell L. Shiffman , M.D., Stefan Zeuzem , M.D., Antonio Craxi , M.D., Mei-Hsui Ling , Ph.D., Janice Albrecht , Ph.D.
Interferon Alfa-2b Alone Or In Combination With Ribavirin For The Treatment Of Relapse Of Chronic Hepatitis C, Gary L. Davis , M.D., Rafael Esteban-Mur , M.D., Vinod Rustgi , M.D., John Hoefs , M.D., Stuart C. Gordon , M.D., Christian Trepo , M.D., Mitchell L. Shiffman , M.D., Stefan Zeuzem , M.D., Antonio Craxi , M.D., Mei-Hsui Ling , Ph.D., Janice Albrecht , Ph.D.
Internal Medicine Publications
BACKGROUND
Interferon alfa is the only effective treatment for patients with chronic hepatitis C. Forty percent of patients have an initial response to this therapy, but most subsequently relapse. We compared the effect of interferon alone with that of interferon plus oral ribavirin for relapses of chronic hepatitis C.
METHODS
We studied 345 patients with chronic hepatitis C who relapsed after interferon treatment. A total of 173 patients were randomly assigned to receive standard-dose recombinant interferon alfa-2b concurrently with ribavirin (1000 to 1200 mg orally per day, depending on body weight) for six months, and 172 patients were assigned to …