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Full-Text Articles in Medicine and Health Sciences
Effect Of Drug-To-Lipid Ratio On Nanodisc-Based Tenofovir Drug Delivery To The Brain For Hiv-1 Infection, Caroline R. Garcia, Armin T. Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy
Effect Of Drug-To-Lipid Ratio On Nanodisc-Based Tenofovir Drug Delivery To The Brain For Hiv-1 Infection, Caroline R. Garcia, Armin T. Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy
Health & Biomedical Sciences Faculty Publications and Presentations
Background: Combination antiretroviral therapy has significantly advanced HIV-1 infection treatment. However, HIV-1 remains persistent in the brain; the inaccessibility of the blood–brain barrier allows for persistent HIV-1 infections and neuroinflammation. Nanotechnology-based drug carriers such as nanodiscoidal bicelles can provide a solution to combat this challenge.
Methods: This study investigated the safety and extended release of a combination antiretroviral therapy drug (tenofovir)-loaded nanodiscs for HIV-1 treatment in the brain both in vitro and in vivo.
Result: The nanodiscs entrapped the drug in their interior hydrophobic core and released the payload at the desired location and in a controlled release pattern. …