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Full-Text Articles in Medicine and Health Sciences
Altered Dna Methylation Of Cyp2e1 Gene In Schizophrenia Patients With Tardive Dyskinesia, Ping Zhang, Yanli Li, Kesheng Wang, Junchao Huang, Brenda Bin Su, Chun Xu, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Altered Dna Methylation Of Cyp2e1 Gene In Schizophrenia Patients With Tardive Dyskinesia, Ping Zhang, Yanli Li, Kesheng Wang, Junchao Huang, Brenda Bin Su, Chun Xu, Zhiren Wang, Shuping Tan, Fude Yang, Yunlong Tan
Health & Biomedical Sciences Faculty Publications and Presentations
Background
About 20–30% of patients with schizophrenia develop tardive dyskinesia (TD). Oxidative stress is one potential causes of TD. CYP2E1 is considered as an oxidative stress-related gene, however, no study has been reported on the DNA methylation levels of the CYP2E1 in schizophrenia or TD.
Methods
A total of 35 schizophrenia patients with TD, 35 schizophrenia patients without TD (NTD), and 35 health controls (HCs) were collected in Beijing, China. DNA was extracted from peripheral blood samples. The promoter methylation levels of CYP2E1 were detected using pyrosequencing. The generalized linear model (GLM) was used to examine the methylation levels of …