Medicine and Health Sciences Commons^™

Reducing Olanzapine-Induced Weight Gain Side-Effect By Using Betahistine: A Study In The Rat Model, Chao Deng, Jiamei Lian, Nagesh Brahmavar Pai, Xu-Feng Huang

Graduate School of Medicine - Papers (Archive)

Olanzapine is effective at treating multiple domains of schizophrenia symptoms. However, it induces serious metabolic side effects. Antipsychotic drug’s antagonistic affinity to histamine H1 receptors has been identified as a main contributor for weight gain/obesity side effects. This study therefore investigated whether a combined treatment of betahistine (a H1 receptor agonist and H3 receptor antagonist) could reduce the body weight/obesity induced by olanzapine. Female Sprague Dawley rats were treated orally with olanzapine (1 mg/kg, t.i.d.) and/or betahistine (2.67 mg/kg, t.i.d.), or vehicle for two weeks. Rats treated with olanzapine exhibited significant body weight gain and increased food intake. Co-treatment of …

Dietary Fish Oil Preserves Cardiac Function In The Hypertrophied Rat Heart, Peter L. Mclennan, Mahainda Y. Abeywardena, Julie A. Dallimore, Daniel Raederstorff

Graduate School of Medicine - Papers (Archive)

Regular fish or fish oil intake is associated with a low incidence of heart failure clinically, and fish oil-induced reduction in cardiac remodelling seen in hypertrophy models may contribute. We investigated whether improved cardiac energy efficiency in non-hypertrophied hearts translates into attenuation of cardiac dysfunction in hypertrophied hearts. Male Wistar rats (n 33) at 8 weeks of age were sham- operated or subjected to abdominal aortic stenosis to produce pressure-overload cardiac hypertrophy. Starting 3 weeks post-operatively to follow initiation of hypertrophy, rats were fed a diet containing 10% olive oil (control) or 5% fish oil (ROPUFA30 (17% EPA, 10% DHA)) …

The Effect Of Vasoconstrictors On Oxygen Consumption In Resting And Contracting Skeletal Muscle Of The Autologous Pump-Perfused Rat Hindlimb, Andrew Hoy, Peter L. Mclennan, Gregory E. Peoples

Graduate School of Medicine - Papers (Archive)

No abstract provided.

Glutathione And Catalase Suppress Tgfß-Induced Cataract-Related Changes In Cultured Rat Lenses And Lens Epithelial Explants, Coral G. Chamberlain, Kylie J. Mansfield, Anna Cerra

Graduate School of Medicine - Papers (Archive)

Purpose: The damaging effects of oxidative stress and transforming growth factor-β (TGFβ)-induced transdifferentiation of lens epithelial cells have both been implicated independently in the etiology of cataract. The aim of this study was to investigate whether the presence of antioxidant systems in the lens influences the ability of lens epithelial cells to respond to TGFβ.

Methods: Whole lenses from young rats were cultured with or without TGFβ in the presence or absence of reduced glutathione (GSH). Lens epithelial explants from weanling rats were used to investigate the effects of GSH and catalase on TGFβ-induced cataract-related changes. Lenses were monitored for …