Medicine and Health Sciences Commons^™

Segregation Of A Latent High Adiposity Phenotype In Families With A History Of Type 2 Diabetes Mellitus Implicates Rare Obesity-Susceptibility Genetic Variants With Large Effects In Diabetes-Related Obesity, Arthur B. Jenkins, Marijka Batterham, Dorit Samocha-Bonet, Katherine Tonks, Jerry R. Greenfield, Lesley V. Campbell

Faculty of Science, Medicine and Health - Papers: part A

Background We recently reported significantly greater weight gain in non-diabetic healthy subjects with a 1st degree family history (FH+) of type 2 diabetes mellitus (T2DM) than in a matched control group without such history (FH−) during voluntary overfeeding, implying co-inheritance of susceptibilities to T2DM and obesity. We have estimated the extent and mode of inheritance of susceptibility to increased adiposity in FH+.

Methods Normoglycaemic participants were categorised either FH+ (≥1 1st degree relative with T2DM, 50F/30M, age 45±14 (SD) yr) or FH− (71F/51M, age 43±14 yr). Log-transformed anthropometric measurements (height, hip and waist circumferences) and lean, bone and fat mass …

Evolution Of Sfbi Encoding Streptococcal Fibronectin-Binding Protein I: Horizontal Genetic Transfer And Gene Mosaic Structure, Rebecca J. Towers, Peter K. Fagan, Susanne R. Talay, Bart J. Currie, Kadaba S. Sriprakash, Mark J. Walker, Gursharan S. Chhatwal

Faculty of Science, Medicine and Health - Papers: part A

Streptococcal fibronectin-binding protein is an important virulence factor involved in colonization and invasion of epithelial cells and tissues by Streptococcus pyogenes. In order to investigate the mechanisms involved in the evolution of sfbI, the sfbI genes from 54 strains were sequenced. Thirty-four distinct alleles were identified. Three principal mechanisms appear to have been involved in the evolution of sfbI. The amino-terminal aromatic amino acid-rich domain is the most variable region and is apparently generated by intergenic recombination of horizontally acquired DNA cassettes, resulting in a genetic mosaic in this region. Two distinct and divergent sequence types that …

A Genetic Classification Of Floodplains, G C. Nanson, J C. Croke

Faculty of Science, Medicine and Health - Papers: part A

Floodplains are formed by a complex interaction of fluvial processes but their character and evolution is essentially the product of stream power and sediment character. The relation between a stream's ability to entrain and transport sediment and the erosional resistance of floodplain alluvium that forms the channel boundary provides the basis for a genetic classification of floodplains. Three classes are recognised: (1) high-energy non-cohesive; (2) medium-energy non-cohesive; and (3) low-energy cohesive floodplains. Thirteen derivative orders and suborders, ranging from confined, coarse-grained, non-cohesive floodplains in high-energy environments to unconfined fine-grained cohesive floodplains in low-energy environments, are defined on the basis of …