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Evaluation Of 18F-Iam6067 As A Sigma-1 Receptor Pet Tracer For Neurodegeneration In Vivo In Rodents And In Human Tissue, François Xavier Lepelletier, Matthias Vandesquille, Marie Claude Asselin, Christian Prenant, Andrew C. Robinson, David M.A. Mann, Michael Green, Elizabeth Barnett, Samuel D. Banister, Marco Mottinelli, Christophe Mesangeau, Christopher R. Mccurdy, Inga B. Fricke, Andreas H. Jacobs, Michael Kassiou, Hervé Boutin

Faculty and Student Publications

© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. The sigma 1 receptor (S1R) is widely expressed in the CNS and is mainly located on the endoplasmic reticulum. The S1R is involved in the regulation of many neurotransmission systems and, indirectly, in neurodegenerative diseases. The S1R may therefore represent an interesting neuronal biomarker in neurodegenerative diseases such as Parkinson's (PD) or Alzheimer's diseases (AD). Here we present the characterisation of the S1R-specific 18F-labelled tracer 18F-IAM6067 in two animal models and in human …