Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Differential Ketogenic Diet-Induced Shift In Csf Lipid/Carbohydrate Metabolome Of Pediatric Epilepsy Patients With Optimal Vs. No Anticonvulsant Response: A Pilot Study, Susan A. Masino, David N. Ruskin, Natalie R. Freedgood, Marie Lindefeldt, Maria Dahlin
Differential Ketogenic Diet-Induced Shift In Csf Lipid/Carbohydrate Metabolome Of Pediatric Epilepsy Patients With Optimal Vs. No Anticonvulsant Response: A Pilot Study, Susan A. Masino, David N. Ruskin, Natalie R. Freedgood, Marie Lindefeldt, Maria Dahlin
Faculty Scholarship
Background: The low carbohydrate, high fat ketogenic diet can be an effective anticonvulsant treatment in some pediatric patients with pharmacoresistant epilepsy. Its mechanism(s) of action, however, remain uncertain. Direct sampling of cerebrospinal fluid before and during metabolic therapy may reveal key changes associated with differential clinical outcomes. We characterized the relationship between seizure responsiveness and changes in lipid and carbohydrate metabolites. Methods: We performed metabolomic analysis of cerebrospinal fluid samples taken before and during ketogenic diet treatment in patients with optimal response (100% seizure remission) and patients with no response (no seizure improvement) to search for differential diet effects in …
Dietary Intervention For Canine Epilepsy: Two Case Reports, Susan A. Masino, Natalie R. Freedgood, Hannah R. Reichert, Chris J. Director, Vicky H. Whittemore, Beth Zupec-Kania
Dietary Intervention For Canine Epilepsy: Two Case Reports, Susan A. Masino, Natalie R. Freedgood, Hannah R. Reichert, Chris J. Director, Vicky H. Whittemore, Beth Zupec-Kania
Faculty Scholarship
© 2019 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy. Epilepsy is a common neurologic disorder in humans and domesticated canines. In both species the etiology is diverse and complex, and even with medication a significant portion of the population does not experience sufficient seizure control and/or has unacceptable side effects. Humans often try alternatives such as dietary therapy or brain surgery, but in dogs, brain surgery is rarely an option and, despite potential benefits, there are no standard recommendations for a dietary approach. Herein we describe 2 retrospective case studies detailing …
Editorial: Metabolic Control Of Brain Homeostasis, Detlev Boison, Jochen C. Meier, Susan A. Masino
Editorial: Metabolic Control Of Brain Homeostasis, Detlev Boison, Jochen C. Meier, Susan A. Masino
Faculty Scholarship
No abstract provided.
Metabolic Dysfunction Underlying Autism Spectrum Disorder And Potential Treatment Approaches, Ning Cheng, Jong M. Rho, Susan A. Masino
Metabolic Dysfunction Underlying Autism Spectrum Disorder And Potential Treatment Approaches, Ning Cheng, Jong M. Rho, Susan A. Masino
Faculty Scholarship
Autism spectrum disorder (ASD) is characterized by deficits in sociability and communication, and increased repetitive and/or restrictive behaviors. While the etio-pathogenesis of ASD is unknown, clinical manifestations are diverse and many possible genetic and environmental factors have been implicated. As such, it has been a great challenge to identify key neurobiological mechanisms and to develop effective treatments. Current therapies focus on co-morbid conditions (such as epileptic seizures and sleep disturbances) and there is no cure for the core symptoms. Recent studies have increasingly implicated mitochondrial dysfunction in ASD. The fact that mitochondria are an integral part of diverse cellular functions …
Ketogenic Diet Alters Dopaminergic Activity In The Mouse Cortex [Post-Print], William H. Church, Ryan E. Adams, Livia S. Wyss
Ketogenic Diet Alters Dopaminergic Activity In The Mouse Cortex [Post-Print], William H. Church, Ryan E. Adams, Livia S. Wyss
Faculty Scholarship
The present study was conducted to determine if the ketogenic diet altered basal levels of monoamineneurotransmitters in mice. The catecholamines dopamine (DA) and norephinephrine (NE) and the indolamine serotonin (5HT) were quantified postmortem in six different brain regions of adult mice fed a ketogenic diet for 3 weeks. The dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindole acetic acid (5HIAA) were also measured. Tissue punches were collected bilaterally from the motor cortex, somatosensory cortex,nucleus accumbens, anterior caudate–putamen, posterior caudate–putamen and the midbrain. Dopaminergic activity, as measured by the dopamine metabolites to dopamine content ratio …
Homeostatic Control Of Brain Function – New Approaches To Understand Epileptogenesis, Detlev Boison, Ursula S. Sandau, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Homeostatic Control Of Brain Function – New Approaches To Understand Epileptogenesis, Detlev Boison, Ursula S. Sandau, David N. Ruskin, Masahito Kawamura Jr., Susan A. Masino
Faculty Scholarship
Neuronal excitability of the brain and ongoing homeostasis depend not only on intrinsic neuronal properties, but also on external environmental factors; together these determine the functionality of neuronal networks. Homeostatic factors become critically important during epileptogenesis, a process that involves complex disruption of self-regulatory mechanisms. Here we focus on the bioenergetic homeostatic network regulator adenosine, a purine nucleoside whose availability is largely regulated by astrocytes. Endogenous adenosine modulates complex network function through multiple mechanisms including adenosine receptor-mediated pathways, mitochondrial bioenergetics, and adenosine receptor-independent changes to the epigenome. Accumulating evidence from our laboratories shows that disruption of adenosine homeostasis plays a …