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Full-Text Articles in Medicine and Health Sciences
Establishing The Minimum Clinically Important Difference (Mcid) Of The Quality Of Life In Childhood Epilepsy Questionnaire (Qolce-55), Mariela Leda
Electronic Thesis and Dissertation Repository
The Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) is a validated, parent-reported measure of health-related quality of life (HRQOL) in children with epilepsy (CWE). The QOLCE-55 currently has no minimum clinically important difference (MCID), which is the minimum amount of change required to be considered meaningful to patients. The primary objective of this study was to estimate the MCID for the QOLCE-55 using the Making Mindfulness Matter© in Children with Epilepsy trial data. Parent-child dyads (n=66) completed the QOLCE-55 at baseline (week 0) and follow-up (week 9). MCID values for the QOLCE-55 were calculated using two types of methods: …
Adverse Effects And Pharmacokinetic Characteristics Of High-Dose Glucocorticoid Treatment In Children With Rheumatic Diseases, Renee X. Pang
Adverse Effects And Pharmacokinetic Characteristics Of High-Dose Glucocorticoid Treatment In Children With Rheumatic Diseases, Renee X. Pang
Electronic Thesis and Dissertation Repository
This integrated-article thesis explores the impact of long-term glucocorticoid (GC) therapy on children with RD. Long-term GC treatment is potentially associated with severe adverse drug reactions (ADRs). Our scoping review summarizes the current evidence health-related quality of life (HRQOL) impacts of this treatment on children with RD. We describe the frequency of ADRs related to long-term GC treatment in a convenience sample of pediatric RD patients on long-term prednisone therapy and evaluate clinical characteristics that may be associated with risk for of GC-related ADRs. Lastly, we present a pilot study to evaluate the feasibility of monitoring GC PK in children …
Return To Play: Impact Of Urbanicity And Socioeconomic Status On Parents’ Attitudes Regarding Their Children's Play And Sport During The Covid-19 Pandemic, Kendall Saravanamuttoo
Return To Play: Impact Of Urbanicity And Socioeconomic Status On Parents’ Attitudes Regarding Their Children's Play And Sport During The Covid-19 Pandemic, Kendall Saravanamuttoo
Electronic Thesis and Dissertation Repository
The COVID-19 pandemic has had a profound impact on the daily routines of parents and children. The primary aim of this study was to explore the influence of socioeconomic status (SES) and urbanicity on parents’ attitudes toward their children’s active play opportunities 6 months and 1.5 years into COVID-19. The secondary objective was to explore how parents’ attitudes at 6 months related to the structured and unstructured play opportunities that children returned to 1 year later, while moderating the effects of SES and urbanicity. A sample of 239 Ontario parents of children (< 12) completed two online surveys (August – December 2020; 2021). In general, parents in communities with urban features (e.g., densely populated areas), single-parents, full-time employed parents, and parents of lower-income were more hesitant to return their children to active play during the pandemic. Findings from this work highlight SES and urbanicity disparities that continue to exist during COVID-19.