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Full-Text Articles in Medicine and Health Sciences
Radiomics For Response Assessment After Stereotactic Radiotherapy For Lung Cancer, Sarah A. Mattonen
Radiomics For Response Assessment After Stereotactic Radiotherapy For Lung Cancer, Sarah A. Mattonen
Electronic Thesis and Dissertation Repository
Stereotactic ablative radiotherapy (SABR) is a guideline-specified treatment option for patients with early stage non-small cell lung cancer. After treatment, patients are followed up regularly with computed tomography (CT) imaging to determine treatment response. However, benign radiographic changes to the lung known as radiation-induced lung injury (RILI) frequently occur. Due to the large doses delivered with SABR, these changes can mimic the appearance of a recurring tumour and confound response assessment. The objective of this work was to evaluate the accuracy of radiomics, for prediction of eventual local recurrence based on CT images acquired within 6 months of treatment. A …
Hyperpolarized 3he Magnetic Resonance Imaging Phenotypes Of Chronic Obstructive Pulmonary Disease, Damien Pike
Hyperpolarized 3he Magnetic Resonance Imaging Phenotypes Of Chronic Obstructive Pulmonary Disease, Damien Pike
Electronic Thesis and Dissertation Repository
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the world. Identifying clinically relevant COPD phenotypes has the potential to reduce the global burden of COPD by helping to alleviate symptoms, slow disease progression and prevent exacerbation by stratifying patient cohorts and forming targeted treatment plans. In this regard, quantitative pulmonary imaging with hyperpolarized 3He magnetic resonance imaging (MRI) and thoracic computed tomography (CT) have emerged as ways to identify and measure biomarkers of lung structure and function. 3He MRI may be used as a tool to probe both functional and structural properties of the lung …