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Full-Text Articles in Medicine and Health Sciences

Do Bilingual Speakers Shift Fundamental Frequency Based On Language Acquisition Or Language Dominance?, Nydia Abigail Mendez Jan 2017

Do Bilingual Speakers Shift Fundamental Frequency Based On Language Acquisition Or Language Dominance?, Nydia Abigail Mendez

ETD Archive

As Spanish-English bilingual speakers continue becoming a growing part of the population in the United States it is essential to investigate their acoustic measures. The purpose of this study was to investigate a possible shift in fundamental frequency (F0) measures in bilingual speakers, and it sought to determine whether that shift was based on language acquisition or language dominance. Eleven Spanish-English bilinguals were asked to complete the following tasks 1) answer the Language Experience and Proficiency Questionnaire (LEAP-Q) 2) complete 3 Spanish and 3 English category fluency trials by naming words belonging to a category (e.g. animals), each one minute …


Patterns Of Vocal Fold Closure In Professional Singers, Carie L. Vokar Jan 2017

Patterns Of Vocal Fold Closure In Professional Singers, Carie L. Vokar

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The present study aimed to investigate differences in vocal fold (VF) closure patterns in singers of varying genres with use of videostroboscopy. Three participants were selected to be in groups of different singing genres including classical, musical theatre, and pop/rock. A control group of non-singers were also included. Vocal tasks were assessed through acoustic, subjective, and stroboscopic analysis.

Significant differences were observed between the classical group of singers and the pop/rock group. The VF closure patterns were relatively normal for the classical singers in comparison to the abnormal patterns in pop/rock singers. The musical theatre group had both normal and …


Determination Of Novel Metabolites Of Therapeutic Agents Used In The Treatment Of Castration-Resistant Prostate Cancer, Mohammad Alyamani Jan 2017

Determination Of Novel Metabolites Of Therapeutic Agents Used In The Treatment Of Castration-Resistant Prostate Cancer, Mohammad Alyamani

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Despite an array of improved treatment options over the past decade, prostate cancer remains the second leading cause of cancer mortality for men in the United States. Abiraterone and galeterone are oral steroidal compounds that are used to treat metastatic castration-resistant prostate cancer (CRPC). Abiraterone blocks 17a-hydroxylase/17,20-lyase (CYP17A1), an enzyme required for androgen synthesis. Galeteron inhibits CYP17A1, blocks the androgen receptor (AR), and decreases AR protein levels. Both drugs share the same structure with endogenous androgens such as dehydroepiandrosterone, which are substrates for the enzyme, 3ß-hydroxysteroid dehydrogenase (3ßHSD). Metabolites of 3ßHSD undergo further metabolism to produce the AR ligand, testosterone …


Therapeutic Potential Of Rhtrail For Malignant Melanoma, Katherine Ann Turner Jan 2017

Therapeutic Potential Of Rhtrail For Malignant Melanoma, Katherine Ann Turner

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The application of recombinant human Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (rhTRAIL) for the treatment of cancer holds great promise due to its ability to selectively induce apoptosis in cancer cells while not harming normal healthy cells. This is evident by the robust levels of apoptosis induced in malignant melanoma cells while no event of apoptosis was observed in the non-transformed counterpart of melanomas, melanocytes. However, the clinical utility of rhTRAIL is limited due to the heterogeneity seen in rhTRAIL-sensitivity among cancers. rhTRAIL-resistance is especially prevalent in cases of malignant melanoma. Melanoma rhTRAIL-resistance can be attributed to a number of different …


Title Examination Of Somatic Symptomatology Using The Cleveland Adaptive Personality Inventory And The Dimensional Somatic Questionnaire, Elizabeth Kisela Jan 2017

Title Examination Of Somatic Symptomatology Using The Cleveland Adaptive Personality Inventory And The Dimensional Somatic Questionnaire, Elizabeth Kisela

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This study was designed to assess the reliability and validity of the Cleveland Adaptive Personality Inventory (CAPI) and the Dimensional Somatic Questionnaire (DSQ) on the chronic pain population, depression population, and healthy control population. A total of 178 chronic pain participants, 208 depression participants, and 220 healthy control participants were collected, though not all were used for analysis due to missing data. Each participant was administered an online version of the CAPI with the Dimensional Somatic Questionnaire. Both questionnaires were significantly shortened during or prior to analysis. The questionnaires were shortened to make them more practical for use in the …


He Repercussions Of Childhood Trauma On Posttraumatic Stress: The Mediating Effects Of Dissociation And Emotion Dysregulation, Jessica A. Ward Jan 2017

He Repercussions Of Childhood Trauma On Posttraumatic Stress: The Mediating Effects Of Dissociation And Emotion Dysregulation, Jessica A. Ward

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The present study explored the mediating effects of dissociation and emotion dysregulation on the relationship between different types of childhood trauma and symptoms of posttraumatic stress. Participants were 181 undergraduate students at Cleveland State University, who competed measures of childhood trauma (emotional abuse, physical abuse, sexual abuse, and general trauma), posttraumatic stress symptoms, dissociation, and emotion dysregulation. Multiple mediation analyses were conducted to examine the model proposed in this study. The results of this study revealed that all trauma types significantly predicted adulthood posttraumatic stress. The relationship between emotional abuse and posttraumatic stress was mediated through both dissociation and emotion …


How The Illness Experience Predicts Key Psychosocial Outcomes In Veterans With Brain Injury, Carmen M. Tyler Jan 2017

How The Illness Experience Predicts Key Psychosocial Outcomes In Veterans With Brain Injury, Carmen M. Tyler

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The object of this thesis was to examine the illness experience of veterans who have suffered either a stroke or traumatic brain injury. Predictors of key psychosocial outcomes were identified by looking at the illness experience through the veterans’ perspective via self-report measures. Results confirmed relationships between the stressors role captivity, low self-esteem, decreased socialization, and dyad relationship strain and the outcome of depression and between the stressors physical strain and emotional strain and the outcome social/recreational participation for this population. More importantly, role captivity, social/recreational strain, and self-esteem uniquely predicted depression, and both physical and emotional strain uniquely predicted …


Construct Validity For The Poreh Nonverbal Memory Test On Participants With Right, Left, And Bilateral Temporal Lobe Epilepsy, Sarah E. Tolfo Jan 2017

Construct Validity For The Poreh Nonverbal Memory Test On Participants With Right, Left, And Bilateral Temporal Lobe Epilepsy, Sarah E. Tolfo

ETD Archive

The present study examined the construct validity of a novel nonverbal memory measure, the Poreh Nonverbal Memory Test (PNMT), using a heterogeneous sample of patients with epilepsy. Results from this study shows that the PNMT differentially correlated with existing memory measures. Namely, the PNMT delay scores significantly correlated with ROCF delay scores, and RAVLT delay and ROCF delay scores were significantly correlated with each other. However, the PNMT did not significantly correlate with RAVLT, which was hypothesized. PNMT and RAVLT learning trials produced logarithmic learning curves that indicate both are good measures of learning. When controlling for gender, education, and …


Decline Of Nonverbal Executive Functions Across The Lifespan – Distinguishing Between Outcome And Process, Anna Krivenko Jan 2017

Decline Of Nonverbal Executive Functions Across The Lifespan – Distinguishing Between Outcome And Process, Anna Krivenko

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Numerous studies have attempted to validate nonverbal fluency tests but none have examined construct validity, particularly the correlation of measures and self-reported executive functioning deficits. The current study examined this issue by correlating the results of the Five-Point Test (5PT) and the Delis Kaplan Executive Functioning System (D-KEFS) Design Fluency Test with the Barkley Deficits in Executive Functioning Scale – Short Form (BDEFS-SF) in 306 English speaking adults. Participants were volunteers from undergraduate classes and those serving jury duty in a large urban city. The mean age was 36.89 ± 18.08 with an average of 14.65 ± 2.85 years of …


Testing The Impact Of Post-Traumatic Stress On Existential Motivation For Ideological Close- And Open-Mindedness, Lauren M. Kahle Jan 2017

Testing The Impact Of Post-Traumatic Stress On Existential Motivation For Ideological Close- And Open-Mindedness, Lauren M. Kahle

ETD Archive

The present thesis builds on terror management theory and anxiety buffer disruption theory to propose that although existential motivation normally leads people to become more certain of their worldviews, traumatic experiences can disrupt those belief systems and cause people to respond to death-awareness by making an open-minded search for alternative belief systems instead. To test that hypothesis, groups of participants with low and high levels of traumatic stress were reminded of death (vs. a control topic condition), followed by an assessment of closed- and open-mindedness. Thus, the present research explored the previously untested hypothesis that increased awareness of mortality will …


Developmental Disabilities And Family Dynamics, Meghan Murray Jan 2017

Developmental Disabilities And Family Dynamics, Meghan Murray

ETD Archive

Typically developing (TD) siblings of children with an Intellectual or Developmental Disability (IDD) are among those most influenced by their sibling’s diagnosis. Factors such as increased family stress, lack of family communication, and negative sibling perception can play a role in leading to internalizing and externalizing problems from the TD child. A limit to the existing sibling relationship literature is that the relationships in families with a child with IDD have only been collected via self-report measures through which respondents have been found to fake their responses to avoid being perceived in certain ways. Conversely, implicit measures, such as the …


The Utilization Of Eyetracking To Understand Attention Switching In Socially Anxious And Depressed Individuals, Allison E. Griesmer Jan 2017

The Utilization Of Eyetracking To Understand Attention Switching In Socially Anxious And Depressed Individuals, Allison E. Griesmer

ETD Archive

Individuals with social anxiety disorder (SAD) and major depressive disorder (MDD) have demonstrated differences in attention bias processing, leading to a differential processing of the world around them. As such, there is a pressing need to further understand these hypothesized attentional biases to lend to improved therapeutic deliveries. The present study utilized a novel eye-tracking paradigm to understand attentional biases in individuals with disorder-specific symptomology of SAD and MDD. A sample of 103 undergraduates completed measures of social anxiety, depression and a novel eye-tracking paradigm. Results showed that a combination of elevated SAD and MDD symptoms lends to a slower …


Testing Emotion Regulation And Parasympathetic Nervous System Deficits As A Mechanism For The Transmission Of Borderline Personality Disorder, Julia R. Richmond Jan 2017

Testing Emotion Regulation And Parasympathetic Nervous System Deficits As A Mechanism For The Transmission Of Borderline Personality Disorder, Julia R. Richmond

ETD Archive

The present study explored the role of parental physiological state and parental emotion regulation (ER) deficits on the relationship between parent borderline personality disorder (BPD) symptoms and child BPD symptoms. Participants were 110 adolescents aged 11-13 years and their legal guardians who completed measures of BPD symptom severity and emotion dysregulation before engaging in an interpersonal conflict discussion task while being monitored for peripheral psychophysiological signals (i.e., respiratory sinus arrhythmia; RSA). Multiple mediation analyses were conducted to examine the model proposed in this study. The results revealed that parent BPD symptoms predicted lower parent baseline RSA at trend level, but …


Change Detection Of Emotional Information Across The Adult Lifespan, Maria J. Donaldson-Misener Jan 2017

Change Detection Of Emotional Information Across The Adult Lifespan, Maria J. Donaldson-Misener

ETD Archive

Visual change detection ability is necessary for successful interaction with the environment, yet few studies have been conducted on change detection with older adults, and whether their use of top-down and bottom-up processing differs from younger adults, especially with emotional processing. Emotions can be motivating and guide the scope of attention using top-down processing and can capture attention in an automatic, bottom-up fashion. Theories of socioemotional aging suggest that younger and older adults may be differentially motivated to process positive and/or negative aspects of the environment, and these tendencies may have implications for age-related trajectories in well-being. Change detection efficacy …


Identity And Career Experiences Of Muslim Immigrant Women: The United States Context, Basak Kacar Khamush Jan 2017

Identity And Career Experiences Of Muslim Immigrant Women: The United States Context, Basak Kacar Khamush

ETD Archive

Muslim women's sense of self is at stake due to prevailing stigma and oppression toward Muslims. Employment and workplace have emerged as primary settings for encounters of negative bias, prejudice, and discrimination. Muslim immigrant women face multiple disadvantages on the basis of their various intersecting identities. The purpose of this study was to explore identity and career experiences of first generation immigrant Muslim women in American society, particularly in work and career settings. Informed by relational approaches to career development and social identity perspective, and grounded on the constructivist paradigm, a phenomenological qualitative analysis using consensual qualitative research (CQR) was …


Gender Role Prescriptions And Apologies, Molly Fuller Jan 2017

Gender Role Prescriptions And Apologies, Molly Fuller

ETD Archive

Malpractice litigations in the medical field are common occurrences. In fact, across specialties, 7.4% of physicians annually have a malpractice claim. Malpractice risk exists for all physicians regardless of their medical training, gender, specialization, or severity of damage caused to patients. Data from nearly 20 years of research revealed that male physicians face malpractice claims at a significantly higher rate than female physicians, but that female physicians pay more in malpractice settlements than their male counterparts. To date, we have found no research that investigates why this gender discrepancy among malpractice settlements occurs. This study examines Social Role Theory and …