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The Buccal Cytome And Micronucleus Frequency Is Substantially Altered In Down’S Syndrome And Normal Ageing Compared To Young Healthy Controls, Philip Thomas, Sarah Harvey, Tini Gruner, Michael Fenech
The Buccal Cytome And Micronucleus Frequency Is Substantially Altered In Down’S Syndrome And Normal Ageing Compared To Young Healthy Controls, Philip Thomas, Sarah Harvey, Tini Gruner, Michael Fenech
Dr Tini M Gruner
The buccal micronucleus cytome assay was used to investigate biomarkers for DNA damage, cell death and basal cell frequency in buccal cells of healthy young, healthy old and young Down's syndrome cohorts. With normal ageing a significant increase in cells with micronuclei (P < 0.05, average increase +366%), karyorrhectic cells (P < 0.001, average increase +439%), condensed chromatin cells (P < 0.01, average increase +45.8%) and basal cells (P < 0.001, average increase +233%) is reported relative to young controls. In Down's syndrome we report a significant increase in cells with micronuclei (P < 0.001, average increase +733%) and binucleated cells (P < 0.001, average increase …