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No-Independent Modulation Of Soluble Guanylyl Cyclase (Sgc) Activity And Function, George L. Britton Jr
No-Independent Modulation Of Soluble Guanylyl Cyclase (Sgc) Activity And Function, George L. Britton Jr
Dissertations & Theses (Open Access)
Soluble guanylyl cyclase (sGC) plays a key role in the nitric oxide (NO) signaling pathway, where it functions as an NO receptor and generator of a secondary intracellular messenger, cGMP. In addition to NO, investigators have identified a number of proteins that interact with sGC and modulate its function. For example, the interaction of sGC with ADP-ribosylation factor GTPase activating protein 1 (AGAP1) governs sGC’s intracellular distribution and therefore mediates localized production of cGMP. Interactions of sGC with heat-shock protein 90 (HSP90) or HSP70 promote the extent of sGC activation upon NO stimulation, while interaction of sGC with the η …