Medicine and Health Sciences Commons^™

Resting-State Functional Connectivity In Youth With Gender Dysphoria, Felix L. Garcia

Dissertations, Theses, and Capstone Projects

Current developmental models of gender identity and gender dysphoria (GD) lack sex-specific profiles of brain function that differentiate between typically-developing and cross-gender identified youth, as postulated by models like the unified theory of the origins of sex differences (Arnold, 2009) and the neurobiological theory of the origins of transsexuality (Swaab & Garcia-Falgueras, 2009). Previously, investigators have used brain imaging modalities such as Resting-State functional Magnetic Resonance Imaging (R-fMRI) to demonstrate differences in resting-state functional connectivity (RSFC) between typically-developing male and female youth, and between typically-developing and GID-diagnosed youth. In the present pilot study, I used R-fMRI to investigate differences in …

Demystifying The Placebo Effect, Phoebe Friesen

Dissertations, Theses, and Capstone Projects

This dissertation offers a philosophical analysis of the placebo effect. After offering an overview of recent evidence concerning the phenomenon, I consider several prominent accounts of the placebo effect that have been put forward and argue that none of them are able to adequately account for the diverse instantiations of the phenomenon. I then offer a novel account, which suggests that we ought to think of the placebo effect as encompassing three distinct responses: conditioned placebo responses, cognitive placebo responses, and network placebo responses. Next, I consider implications of the placebo effect’s role in complementary and alternative medicine for discussions …

Casualties Of Racism: Racial And Ethnic Discrimination And Suicidal Thoughts And Behaviors Among Racial And Ethnic Minority Emerging Adults, Lillian Anais Polanco

Dissertations, Theses, and Capstone Projects

The evidence demonstrating that experiences of racial/ethnic discrimination is detrimental to the mental health of racial/ethnic minority youth is unequivocal. What remains unclear, however, is whether racial/ethnic discrimination increases vulnerability for suicidal thoughts and behaviors in particular, and if so, what are the underlying mechanisms to explain this relation. Drawing upon the Race-based Traumatic Stress Theory (Carter, 2007), which suggests that some individuals may experience racial/ethnic discrimination as a traumatic stressor, and thus, eliciting a traumatic stress response, the present study examined posttraumatic stress reactions (i.e., posttraumatic stress, depression, dissociation, stress sensitivity) as mediators in the relation between racial/ethnic discrimination …

Diagnosing The Will To Suffer: Lovesickness In The Medical And Literary Traditions, Jane Shmidt

Dissertations, Theses, and Capstone Projects

Throughout Western medical history, unconsummated, unreturned, or otherwise failed love was believed to generate a disorder of the mind and body that manifested in physiological and psychological symptoms. This study traces the medical and literary history of lovesickness from antiquity through the 19^th century, emphasizing significant moments in the development of the medical discourse on love. The project is part of the recent academic focus on the intersection between the humanities and the medical sciences, and it situates literary texts in concurrent medical and philosophical debates on afflictions of the psyche. By contextualizing the fictional works within the scientific …

The Effect Of A Voice Treatment On Facial Expression In Parkinson’S Disease: Clinical And Demographic Predictors, Amanda D. Bono

Dissertations, Theses, and Capstone Projects

Parkinson’s disease (PD) is a neurodegenerative disease associated with a wide range of motoric, cognitive, and behavioral symptoms. Impairments in facial mobility and emotional expressivity are common and can impair communication, in turn, affecting daily functioning and quality of life. Previous research suggests that the Lee Silverman Voice Treatment © (LSVT LOUD; Ramig et al., 2001, 2011) increases vocal loudness and facial expressivity in individuals with PD compared to PD and healthy controls. This study extends the literature by examining the effects of LSVT and an articulation-based control treatment (i.e., ARTIC) on multiple aspects of facial expressivity (i.e., emotional frequency …

Increasing Access To Pre-Exposure Prophylaxis (Prep) Among Transgender Women And Trans Feminine Non-Binary Individuals In New York City, Augustus Klein

Dissertations, Theses, and Capstone Projects

In the United States transgender women (i.e., individuals born male whose gender identity is on the feminine spectrum) are a highly vulnerable and marginalized population at high risk for HIV. Substance use, survival sex work, depression, unstable housing, and high levels of victimization and violence are commonly reported by transgender women and trans feminine individuals, indicating the potential for multiple concurrent HIV risks and underlying vulnerabilities. Structural forms of discrimination may contribute to these risk factors, possibly leading to poor outcomes such as unemployment or underemployment, homelessness, and lack of access to gender-affirming health care. Given this context, a biomedical …

Strategies Involving The Food-Derived Agent Curcumin To Eliminate Brain Cancer, Sumit Mukherjee

Dissertations, Theses, and Capstone Projects

Glioblastoma (GBM) is one of the most deadly forms of cancer with a mean 5-year survival rate of ≤5%. We have used the non-invasive strategy of long-term intranasal (IN) delivery of a glioblastoma-directed adduct of curcumin (CC), CC-CD68Ab, into the brain of murine GBM cell line GL261-implanted mice to study the therapeutic effect of CC on GBM remission. The treatment caused GBM tumor remission in 50% of GL261-implanted GBM mice. A similar rescue rate (60%) was also achieved through long-term intraperitoneal (i.p) infusion of a highly bioavailable phosphotidylcholine (PC)-encapsulated formulation of CC, Curcumin Phytosome Meriva (CCP), into the GL261-implanted GBM …

The Lived Experience Of Traumatic Amputation For Haitian Adults, Margarett Alexandre

Dissertations, Theses, and Capstone Projects

Amputation of a limb is a traumatic and disabling condition that impacts the lives of people worldwide. Trauma remains the leading cause of major limb amputation, second only to Diabetes Mellitus and dysvascular complications (Ziegler-Graham, MacKenzie, Ephraim, Travison, & Bookmeyer, 2008). Little is known about the experience of traumatic amputation for Haitian Adults, therefore this study was to understand the lived experience of traumatic amputation in Haiti. The purpose of this descriptive phenomenological study was to investigate the lived experience of traumatic amputations as talked about by adults who suffered an amputation because of the 2010 earthquake in Haiti. Eight …

Vowel Production In Down Syndrome: An Ultrasound Study, Micalle Carl

Dissertations, Theses, and Capstone Projects

The present study investigated the articulatory and acoustic characteristics of vowel production in individuals with Down syndrome (DS). Speech production deficits and reduced intelligibility are consistently noted in this population, attributed to any combination of phonological, structural, and/or motor control deficits. Speakers with DS have demonstrated impaired vowel production, as indicated by perceptual, acoustic, and articulatory data, with emerging evidence of vowel centralization. Participants in the study included eight young adults with DS, as well as eight age- and gender-matched controls. Ultrasound imaging was utilized to obtain midsagittal tongue contours during single-word productions, specifically targeting the corner vowels /ɑ/, /æ/, …

Linking Hostile/Helpless Maternal Representations In Pregnancy And Later Child Protection Involvement: A Pilot Study, Madeleine Terry

Dissertations, Theses, and Capstone Projects

The present pilot study examined whether there are reliable indices in the narratives of pregnant women that can be used to identify child abuse and neglect potential before the birth of the child. The Hostile/Helpless (HH) Classification system (Lyons-Ruth et al., 1995-2005), which detects mental states associated with trauma, disturbances in early attachment, and severe pathology, was adapted for use with the Pregnancy Interview (PI), a semi-structured clinical interview (Slade, 2003) that assesses a woman's emotional experience of pregnancy, and quality of her developing relationship with her baby. The study sample was drawn from a replication study of the Minding …

Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee

Dissertations, Theses, and Capstone Projects

Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood and behavior. Cognitive impairments appear to be more localized to specific areas of functioning rather than a global deficit; however, deficits have been identified across multiple cognitive domains including language and aspects of executive functioning. A careful examination of the cognitive phenotype and its association to mutations affecting CNS isoforms is necessary to clarify the neuropsychological …

What’S Your Story? Assessing Childhood Maltreatment Using The Thematic Apperception Test In An Adult Inpatient Population., Thachell C. Tanis

Dissertations, Theses, and Capstone Projects

There is a robust evidence that childhood maltreatment contributes to the development of adult psychopathology (Brown & Anderson, 1991; Johnson, Cohen, Brown, Smailes, & Bernstein 1999; Johnson, Smailes, Cohen, Brown, & Bernstein, 2000; Ruggiero et al., 1999). However, the identification of childhood maltreatment remains a methodological problem that results in inconsistencies in the reported incidence and psychological sequelae of maltreatment. A primary method for identifying histories of childhood maltreatment among adults is retrospective self-report measures which are susceptible to multiple biases (Briere, 1992; Cicchetti & Rizley, 1981; Shaffer, Huston, & Egeland, 2008). This present study suggests that childhood maltreatment can …

Mechanisms Adopted By Dengue-2 Viruses To Induce Autophagy In Mammalian Cells, Sounak Ghosh Roy

Dissertations, Theses, and Capstone Projects

Dengue, the most rapidly spreading flavivirus, threatens to affect almost half of the human global population. We previously showed that dengue-2 protects canine kidney cells (MDCK) from cytotoxic chemicals. We showed, independently, that cell protection, as well as viral replication and maturation, are positively regulated by PI3K-dependent autophagy. However, we had not identified the specific pathway that induces autophagy in infected cells. The current study explores the role of a specific branch of the endoplasmic reticulum (ER) stress-mediated Unfolded Protein Response (UPR), the PERK/eIF2α/ATF4 pathway in the induction of autophagy by …

Stereotype Threat As An Explanation For Sexual Risk Taking Behavior In Gay Men: A Multi-Study Exploration Of Mechanisms, Inna Saboshchuk

Dissertations, Theses, and Capstone Projects

Stereotype threat is a hindrance in performance that occurs when an individual’s awareness of negative stereotypes associated with his/her group results in inadvertent conforming to that stereotype. Stereotype threat research has been conducted on myriad group and domain identifications but gay men are strikingly absent from the stereotype threat literature. One of the most prevalent stereotypes about gay men indicates they are sexually promiscuous and that this promiscuity is linked to HIV infection. In a series of three research projects, a theoretical model proposing stereotype threat as a mechanism for sexual risk taking behavior in gay men is tested. In …

Synthesis And Characterization Of Cytocompatible Sponge-Mimetic Scaffolds And Biomedical Polymers, Kamia Punia

Dissertations, Theses, and Capstone Projects

This dissertation describes the novel synthetic methodologies towards: a) protein/polysaccharide intercalated sponge-mimetic scaffolds for 3D cell culture, b) peptide-mimetic cationic amphiphilic antibacterial polymers, and c) bioactive Poly(DL-lactide-co-glycolide) (PLGA) nanofibers by solution blow spinning for the treatment of cancer and traumatic wound care.

The classic “chemical garden” experiment is reconstructed to produce protein/polysaccharide (ingredients of cyanobacterial origin) intercalated silicate-phosphate tubules that resemble tubular sponges. The constructs were synthesized by seeding calcium chloride into a solution of sodium silicate-potassium phosphate and gelatin/polysaccharides. The morphology and composition of sponge-mimetic tubules were analyzed by a battery of techniques. Bioconjugation and coating protocols were developed …

The Effect Of Nurse Residency Program Completion On Work Readiness Of New Graduate Nurses Transitioning Into Professional Practice, Suzanne Mullings-Carter

Dissertations, Theses, and Capstone Projects

The transition of new graduate nurses from their roles as students to professional nurses is challenging. New graduate nurses have to complete cursory orientation with high performance expectations, increased level of accountability and meet the complex needs of the patients, leading to high turnover rates within the first year of practice.

To address this problem, nurse residency programs have been implemented to support new graduates with the transition into professional nursing. In addition to transitional support, new graduate nurses need to be ready to meet the demands of their new work environment. The problem is determining whether or not new …

Curcumin Inhibits The Ikk:Nf-Kappa B Pathway In Neural Fear Circuits, Miguel A. Briones

Dissertations, Theses, and Capstone Projects

The study of how the brain acquires fearful memories has attracted considerable experimental attention, due in part to the promise of discovering novel therapeutic approaches for psychiatric disorders that are characterized by unusually strong and persistent traumatic memories. In recent years, extensive research has focused on studying the neural and molecular mechanisms by which fear memories are acquired, stored, and retrieved in the brain. Once acquired, fear memories may be attenuated using one of 2 procedures: 1) fear extinction, which involves repeated presentation of the fear-arousing stimulus in the absence of an aversive consequence, or 2) interference with the reconsolidation …

Factors Associated With Household Contacts' Tuberculosis Testing And Evaluation, Elvy G. Barroso

Dissertations, Theses, and Capstone Projects

Contact investigation (CI) is one of the core elements of tuberculosis (TB) control. It is intended to achieve early identification of contacts who may have been exposed to a patient with infectious active TB and contacts who may benefit from treatment for latent tuberculosis infection (LTBI). LTBI is an infection in which the Mycobacterium tuberculosis organisms cause no signs and symptoms but the infection can be reactivated and develop into full-blown active TB disease. Failure to be identified as a contact is the primary reason for disease development in more than half of TB patients, thus a complete and timely …

Hearing Loss And Third Party Disability: A Systematic Review, Kathleen H. Wallace

Dissertations, Theses, and Capstone Projects

Objective: The purpose of this investigation is to conduct a systematic review of the quality of life (QoL), social, and emotional aspects of third party disability experienced by communication partners of persons with hearing loss (PHL), including a comparison of communication partners of users of hearing aids, users of cochlear implants, and unaided persons with hearing loss.

Methods: A comprehensive search utilizing various peer-reviewed databases accessible through the City University of New York (CUNY) Graduate Center Library was conducted to identify relevant studies evaluating quality of life, social, and emotional outcome measures of communication partners of persons with hearing loss …

Perceived Health: A Grounded Theory Study On How Young Black Men Process Their Health, Layla L. Qaabidh

Dissertations, Theses, and Capstone Projects

This dissertation explored the perceptions young, Black men have regarding their health. It also sought to understand behaviors young, Black men engage in to maintain their health.

Individual Differences In Stimulus Frequency Otoacoustic Emission Phase, Joshua J. Hajicek

Dissertations, Theses, and Capstone Projects

Otoacoustic emissions (OAEs) are sounds that originate in the cochlea and are measured in the ear canal. OAEs provide a noninvasive tool for investigating cochlear mechanics. Stimulus-frequency OAEs (SFOAEs) are evoked by presenting a single frequency tone, called a probe tone, which have an advantage over other OAEs because they are the least influenced by cochlear nonlinearities. However, because the SFOAE are generated in the cochlea with the same frequency as the stimulus, additional techniques, such as the use of suppressor tones are needed to enable separation of the probe tone from the SFOAE.

The primary goal of this investigation …

Development Of A Journaling Application To Track Progress Of Adaptation To Amplification For Adult Patients: Deardiary, Nicole C. Snider

Dissertations, Theses, and Capstone Projects

The DEar Diary application is an illustration of concept of an Apple iOS (operating system) application designed as a tool for supporting compliance and satisfaction with the use of amplification. The audiologist’s main purpose is to counsel, support and to provide rehabilitative counseling to their patients. Helping a patient succeed while using hearing devices for the first time is a complicated task which can be accomplished with the proper counseling and helpful tools in place.

The use of a journal to write down experiences and providing written support material the patient can refer to once they are out of the …

The Affective Domain And The Intersection Of Learning In Emergency Medical Technician Paramedic Education, Meghan Williams

Dissertations, Theses, and Capstone Projects

Bloom identified three separate domains for learning: the psychomotor, cognitive, and affective domains. In this thesis, I propose that for paramedic education, the affective domain is not a domain to master equal to the psychomotor and cognitive domains, but must be mastered prior to the other domains in order to fully optimize learning. I propose that students must have a basic ability to apply the skills of the affective domain, and unlike the other domains, mastery of the almost the entire domain must be achieved before a student can complete the two other domains to be successful in a Paramedic …

Dancing, Mindfulness, And Our Emotions: Embracing The Mind, Body, And Sole, Alisha M. Collins

Dissertations, Theses, and Capstone Projects

This capstone project examines dance, as an intervention and mindfulness practice that assists with managing our emotions. There is a need for dance therapy in social institutions such as, healthcare facilities, schools, and community centers. Dance therapy has the potential to reduce negative emotions, create mindfulness, improve self-expression, and promote a healthy well-being. I am proposing that dance therapy is applied as a regular practice in social institutions to develop mindfulness and promote emotional stability.

In this study, I argue that dance therapy can contribute to our well-being long term. In addition to this written thesis, a visual component of …

Effect Of The Diverse Standardized Patient Simulation (Dsps) Cultural Competence Education Strategy On Nursing Students’ Transcultural Self-Efficacy Perceptions, Eda Ozkara San

Dissertations, Theses, and Capstone Projects

Nursing students find it challenging to provide culture-specific care for patients representing diversity in ethnicity, race, language, socioeconomic status, religion, gender, sexual orientation, immigration history, and lifestyle and frequently lack confidence in their knowledge, skills, and abilities. Simulation has become a useful strategy for teaching nursing students assessment skills, technical skills, teamwork, delegation, self-efficacy, and professional communication. An alarming gap exists within the literature concerning innovative teaching and learning strategies that are carefully designed, implemented, and evaluated and follow a conceptual model, guidelines, and standards to enhance cultural competence development of diverse student groups, who must work with patients from …

Culture Care Needs Of Puerto Rican Women Receiving Hiv Care From Nurse Practitioners In New York City, Michele Crespo-Fierro

Dissertations, Theses, and Capstone Projects

The purpose of this mini-ethnonursing research study was to discover, describe, and interpret culture care values, beliefs, expressions, practices and needs of Puerto Rican women receiving HIV care from nurse practitioners (NPs) and other providers in New York City. The emic, or insider, perspective of Puerto Rican women living with HIV was the focus of this study and Leininger’s Culture Care Theory (CCT) provided the theoretical framework. Various enablers of the CCT, including Leininger’s Sunrise Enabler to Discover Culture Care, guided the design andimplementation of the study. Six key and twelve general informantswere interviewed and data from the interviews were …

The Effect Of Hearing Aid Use On Cognition In Older Adults With Adult Onset Hearing Loss: A Systematic Review, Jona Cano

Dissertations, Theses, and Capstone Projects

The goal of this paper was to systematically review literature in order to investigate whether the use of amplification in the form of hearing aids by older adults positively impacts cognitive status. If the results of this review uncover a positive association between hearing-aid use and cognition, then hearing aids can be recommended as an intervention method for the mitigation of cognitive decline. The eight studies included in this paper were reviewed based on the research design and the cognitive outcome measures employed. Additionally, the secondary measures of health utilized by study investigators were also evaluated. Of the eight studies …

Assessing The Ordinality Of Response Bias With Item Response Models: A Case Study Using The Phq-9, Venessa N. Singhroy

Dissertations, Theses, and Capstone Projects

Improper scale usage in psychological and clinical assessment is an important problem. If respondents do not use the scales in a consistent manner, the reliability of a composite is likely to be attenuated. This is particularly problematic when particular items are singled out for special treatment or when subscales are of interest, not just a total score. This study used both non-parametric and parametric item response theory (IRT) methods to gain further insight into the validity of the PHQ-9, a dual purpose instrument that assesses the severity of depressive symptoms using nine Likert-scale items and allows the investigator to establish …

Noise Levels In The Neonatal Intensive Care Unit: A Systematic Review, Esther Cohn

Dissertations, Theses, and Capstone Projects

Advisor: Carol A. Silverman, Ph.D., M.P.H.

Objective: The purpose of this systematic review is to investigate noise levels in the Neonatal Intensive Care Unit (NICU) in order to see if they are in compliance with the American Academy of Pediatrics (AAP) proposed standards. This investigation also aims to compare noise levels among various NICU conditions in order to best hospital conditions for noise reduction.

Methods: A comprehensive search of the literature utilizing various peer-reviewed databases through the City University of New York (CUNY) Graduate Center Library was conducted to identify relevant studies on noise levels in the NICUs. Articles that …

Speech Perception In Mandarin- And Cantonese-Speaking Children With Cochlear Implants: A Systematic Review, Sum Yee Fong

Dissertations, Theses, and Capstone Projects

Background: Current cochlear implants are limited in their ability to convey pitch and tone information. Poor representation of pitch and tone information in cochlear implants hinders lexical tone perception for cochlear-implant users who speak tonal languages such as Mandarin and Cantonese. As the demand for cochlear implants in China is increasing, it is necessary to understand the speech perception abilities of Mandarin and Cantonese-speaking cochlear-implant users and the factors that contribute to improved speech perception for these users.

Objective: The purpose of this investigation is to perform a systematic review on the speech perception abilities in children with cochlear implants …