Medicine and Health Sciences Commons^™

Survey Of Sensory Diet Use Among California Occupational Therapy Practitioners, Morganne Peterson, Allison Hunt, Emily White

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to examine the use of sensory diets in the field of occupational therapy. This study investigated the use of sensory diets among California occupational therapy practitioners. A mixed-methods design was used to collect data through an online survey. The survey was sent out to members of the Occupational Therapy Association of California (OTAC) and received 98 respondents within one month. Participants worked among various clinical settings and implemented sensory diets with various client populations. Practitioners reported using terms such as “sensory strategies,” “sensory tools,” and “sensory supports” which indicates an overall misunderstanding associated with …

Combinational Therapy To Mitigate Α-Dicarbonyl Toxicity, Jessica Ramirez

Dissertations, Masters Theses, Capstones, and Culminating Projects

Diabetes mellitus is a metabolic disease characterized by hyperglycemia that affects 30 million children and adults in the United States alone. Patients suffering from diabetes have high concentrations of reactive α-dicarbonyls (α-DCs) like, methylglyoxal (MGO). The abundance of α-DCs form advanced glycation end products (AGEs); in turn, the accumulation of AGEs has been linked to secondary complications. Secondary complications include diabetic neuropathy, nephropathy and cardiomyopathy. A recently discovered TRPA-1-Nrf-2 pathway is a conserved mechanism in vertebrates and invertebrates that detoxifies α-DCs; however, regulators that activate the detoxification mechanism are currently unknown. Several supplement grade compounds were screened for TRPA-1-Nrf2 induced …

Poct Testing And Importance Of Operator Lock-Out, Nuha Fadlalla

Dissertations, Masters Theses, Capstones, and Culminating Projects

Point-of-Care Testing (POCT) is usually performed at the patient’s bedside by healthcare providers other than laboratory- trained professionals. Rapid growth of POCT is supported by numerous factors which include healthcare provider efficiency, improving diagnostic insight and better patient outcomes. This project study is done to make sure POCT users have adequate training to ensure and enhance the quality and patient safety. The individual performing these tests to be trained properly before he/she is approved to operate the POC devices. One method to ensure POCT operators have met the required training is the lock out approach which will not allow them …

Measuring The Outcomes Of Therapeutic Listening In Children With Learning And Developmental Disabilities, Hannah Tashjian, Donielle Hair, Phoebe Taasan

Dissertations, Masters Theses, Capstones, and Culminating Projects

Anecdotal reports of the Therapeutic Listening ®-Quickshifts (TL-Q) technique report positive effects on child behavior but the individualized approach requires further supporting evidence. TL-Q is an individualized sound-based program used to facilitate sensory processing skills and is believed to improve interpersonal, social, and cognitive skills (Frick & Hacker, 2001). This study examines the use of a standardized protocol to measure the specific outcomes of the TL-Q program using a practice-based evidence (PBE) approach for the purpose of aggregating data for clinical practice. The protocol was used to measure the outcomes of the TL-Q program in a convenience sample of 23 …

Functional Cognitive Activities For Adults With Traumatic Brain Injury: Pilot Case Studies, Ajay Pala, Karen Huang, Ashley Cook

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of these pilot case studies were to investigate the effectiveness of the Functional Cognitive Activities for Adults with Brain Injury: A Sequential Approach (FCA) in generalizing functional cognitive skills across meaningful occupations for adults with traumatic brain injury (TBI). This study was a pretest-posttest design consisted of two participants with TBI.

Both participants attended 14 out of the 16 intervention sessions, twice-a-week for eight-weeks. Pretest-posttest measurements, including the Canadian Occupational Performance Measure (COPM), Kohlman Evaluation of Living Skills, and Goal Attainment Scale (GAS), were used to measure changes in occupational performance. Additionally, a four-month follow-up phone interview using …

Managing Fatigue With Technology For Individuals With Multiple Sclerosis, Janie Grant, May Anne Gamueda, America Ortega, Jordan Song

Dissertations, Masters Theses, Capstones, and Culminating Projects

OBJECTIVE: The purpose of this study was to investigate whether the use of a mobile health application (mHealth app) in conjunction with energy conservation management techniques will result in a decrease in fatigue for adults with multiple sclerosis.

METHOD: Using a quantitative, exploratory, pre-posttest design, we examined outcomes associated with the use of the mHealth app, Pace My Day, by seven participants during one chosen task over two weeks. The app reinforced the use of energy conservation management techniques during the chosen task. Outcome measures included Modified Fatigue Impact Scale (MFIS) and Canadian Occupational Performance Measure (COPM).

RESULTS: There was …

Collaborative Practices In Special Education: An Exploratory Study, Blanka Pentek, Katherine Sadoff, Evelyn Tang

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: This exploratory survey study examined collaborative practices of professionals working in special education. The basis for the survey was the Conceptual Model of Collaboration (CMC), created by Hess and colleagues (2017).

Methods: 27 professionals who work in special education participated. Cross tabulation tests and Pearson's correlation tests were run to determine relationships between the variables.

Results: The findings indicated that the majority of participants value collaboration for student outcomes and professional development. Most participants agreed on common facilitators and barriers to collaboration. Collaboration primarily takes place in IEP meetings, through email and text messaging and is frequent in all …

Pilot Study: Assistive Technology As A Vocational Support For Individuals With Autism Spectrum Disorder, Erin Chaffee, Tina Ho, Kevin Ng

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this pilot study was to determine the effectiveness of video-based instruction (VBI) to support completion of vocational tasks. A mixed-method approach was utilized to explore the use of VBI on a personal digital assistant with individuals with autism spectrum disorder (ASD). Using two assembling cooking tasks, researchers investigated the level of independence with task completion through written instruction versus VBI. The results indicated a small non-significant increase in the level of independence with task completion during the VBI task independent of intelligence quotient (IQ) levels. Participant’s feedback of VBI was also noted as positive to help learn …

Older Adults’ Perspective: Exploring The Experience Of Owning A Guide Dog, Jeffrey Kou, Yvonne Lam, Patricia Lyons, Susan Nguyen

Dissertations, Masters Theses, Capstones, and Culminating Projects

Guide dogs have been shown to be an effective assistive device that can help older adults with low vision navigate their community and improve overall well-being. Despite vast research conducted on pet therapy and dog companionship, limited research exists on the facilitators and barriers of owning a dog guide among older adults with low vision. The purpose of this qualitative phenomenological study is to explore the facilitators and barriers of owning a guide dog as experienced by older adults with low vision participating in Guide Dogs for the Blind (GDB) organization. Data were gathered among seven participants using semi-structured phone …

Age-Related Changes In Visual Processing Speed: A Pilot Study Using The Motor Free Visual Perception Test- 4, Amber Zadravecz, Kassidy Ha, Lauren Gollnick, Stephanie Pawek, Zoe Studer

Dissertations, Masters Theses, Capstones, and Culminating Projects

Older adults are at a significantly increased risk of being involved in motor vehicle accidents. Evidence reveals that visual processing speed decreases with age, which may impact driving. The Motor-Free Visual Perception Test- Third Edition (MVPT-3) is used as a pre-driving assessment and has an age-normed Response Time Index that measures visual processing speed. In 2015, a new version, the new Motor-Free Visual Perception Test- Fourth Edition (MVPT-4), was published. The new MVPT-4 does not yet demonstrate its utility in measuring visual processing speed. The purpose of this study was to explore if differences in visual processing speed between younger …

Living With Fragile X Syndrome: Occupations As An Outcome Measure In A Clinical Trial, Theresa Chase, Ty Duong, Ana Baldinger, Kaylee Gothelf

Dissertations, Masters Theses, Capstones, and Culminating Projects

The purpose of this study was to evaluate the use of semi-structured interviews as an outcome measure in a clinical trial for children with fragile X syndrome (FXS). A qualitative approach was used to analyze twenty-five parent interviews with children with FXS who participated in a double-blind medication trial. Each participant received either sertraline or a placebo. The aim of this research was to assess differences in occupational functioning in the sertraline group and placebo group, that may not have been detected with the use quantitative outcome measures alone. Results showed greater improvements in the sertraline group in areas of …

Resilience And Protective Factors In Older Adults, Jessica Mcclain, Katelyn Gullatt, Caroline Lee

Dissertations, Masters Theses, Capstones, and Culminating Projects

Evidence suggests resilience promotes successful aging in place and protective factors promote resilience. This study sought to investigate whether or not the combination of three protective factors, physical health, social support, and self-efficacy are all of equal importance in predicting resilience among Marin County older adults, or if some individual protective factors have a greater impact on resilience than the others. Fifty-eight participants ages 62 and higher were recruited from senior community programs and personal contacts. Four self-report questionnaires were completed by the participants in this exploratory, cross-sectional, quantitative design. SPSS was used for a descriptive and multivariate analyses to …

Evaluating The Effectiveness Of A Formal Dementia Care Training Program: Abilities Care Experts™, Carmen Joaquin, Michelle D'Amato, April Perez, Louiza Alexandria Villarina, Sophie E. Miller

Dissertations, Masters Theses, Capstones, and Culminating Projects

Overview: Abilities Care Experts™ (ACE™) is an educational training program for nursing staff who care for individuals with dementia in skilled nursing facilities (SNF). The objective of the program is to provide the nursing staff with knowledge, and methods to engage residents’ remaining abilities in order to maximize occupational participation using a stage-specific dementia care approach. ACE™ training has yet to be evaluated for effectiveness in a controlled study design.

Objectives: This study sought to evaluate the effectiveness of the ACE™ training.

Design: The study employed a quantitative, cross-sectional, quasi-experimental design.

Participants: A total of 29 CNAs, 13 ACE™ trained …

Measuring Physiological Responses To Sensation In Typical Adults, Sarah Button, Kristen Christensen, Emily Minor

Dissertations, Masters Theses, Capstones, and Culminating Projects

Objective: Sensory processing issues can have a large negative impact on the ability to participate in daily occupations such as ADLs, access to work, school and leisure environments, and social interactions (Dunn, 2001). The evidence documenting sensory processing issues in adults is sparse. Physiological information can be used as objective evidence to support the claim that those with over-responsivity to sensations are experiencing their environment differently than the typical population. Understanding more about sensory processing in adults may lead to increased recognition of the problem and more opportunities for intervention to increase occupational participation. The purpose of this quantitative study …

Optimization Of Braf V600 Assay As A 2-Step Real-Time Pcr Protocol, Mimi Phuong

Dissertations, Masters Theses, Capstones, and Culminating Projects

The QClamp® BRAF Codon Specific Mutation Detection Kit is a real-time PCR assay for the detection of somatic mutations in codon 600 Valine at exon 15 in the BRAF gene which encodes the serine/threonine protein kinase, using purified DNA. The V600E mutation is the most common BRAF gene mutation found in human cancers. This mutation leads to production of a BRAF protein that is abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even …

Different Methodologies To Characterize And Diagnose Sickle Cell Disease In Both Developed And Developing Nations, Mohammed Alharbi

Dissertations, Masters Theses, Capstones, and Culminating Projects

Sickle cell disease (SCD) is a genetic blood disorder that causes the RBC to become sickle shaped due to a mutation in the β-globin gene encoding the protein hemoglobin. This disease causes reduced oxygen carrying capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant monitoring of this disease is essential. The following review focuses on various methodologies that have emerged in the diagnosis of SCD. Also, low cost methods that can be easily …

Implementation Plan To Integrate The Nanosphere Verigene Assay In A High-Volume Reference Laboratory And The Anticipated Workflow Benefits To Adopting Rapid Blood Culture Testing, Sofia Nazar

Dissertations, Masters Theses, Capstones, and Culminating Projects

Laboratory processing pathways have a significant impact on the overall management of patients with sepsis. Retrieval and isolation of the suspected pathogen from a patient blood culture specimen is required for a definitive diagnosis of bacterial septicemia. Reference laboratories are high-volume facilities most often located some distance away from the collecting facility. Given the lengthy work up already required for blood culture pathogen analysis, reference laboratories must identify ways to optimize every step of the blood culture pathway in the effort to decrease turnaround time and mitigate lag time to final pathogen identification incurred by prolonged collection-to-incubation times. Rapid molecular …

Determination Of The Feasibility Of Using Cell-Free Dna (Cfdna) In The Q-Clamp Kras Codon Specific Mutation Test, Manuel Garcia

Dissertations, Masters Theses, Capstones, and Culminating Projects

KRAS is a proto-oncogene which was first identified in Kirsten rat sarcoma virus. The normal KRAS protein performs an essential function in normal tissue signaling and a mutation of a KRAS gene is an essential step in the development of many cancers. Q-Clamp® KRAS codon specific mutation test is an in vitro real-time qualitative PCR assay for the detection of mutations in the targeted regions and KRAS mutation often serves as a useful marker in drug response. The Q-Clamp® KRAS codon specific mutation test experiment was performed using cell-free extracted DNA (cfDNA) instead of FFPE extracted DNA. The results of …

A Change Of Heart: Internal Narratives, Forgiveness & Health, Keiko Ehret

Dissertations, Masters Theses, Capstones, and Culminating Projects

In this thesis I investigate the interconnectedness of forgiveness as a narrative, as a philosophical, religious and cultural phenomenon, and the ways in which forgiveness is increasingly being used as a vehicle for improving health and psychological well-being. By threading together how scholars in a variety of fields have approached these areas of study, we can better understand the way the interdisciplinary nature of forgiveness grants access to heal not merely relationships with others, but also our bodies, our minds, and our relationship with ourselves.

Important to my investigation is understanding that the life circumstances that prompt forgiveness consist of …

Identification Of Substrate-Selective Histone Deacetylases And Their Inhibitors That Mediate Her2 Transcript Stability, Mariah Alejo

Dissertations, Masters Theses, Capstones, and Culminating Projects

Breast cancer is the most common malignancy diagnosed in women. 15-20% of these cancers overexpress the HER2 (ERRB2) oncoprotein. HER2-positive breast cancers are generally aggressive and are associated with poor prognosis. Unfortunately, only a mere 30% of HER2-positve patients respond to therapies when they are used as a single agent. Combining therapeutics can potentially lead to synergy and improved anticancer efficacy, and there is clearly a need for the development of new HER2-directed therapeutics. Newer approaches include the utilization of histone deacetylase (HDAC) inhibitors. It has been observed that HDAC inhibitors can induce the rapid decay of oncogenic transcripts such …

Novel Effects Of Prefoldin Pathway On Intestinal Homeostasis Via Dietary Restriction In Drosophila Melanogaster, Jesse Simons

Dissertations, Masters Theses, Capstones, and Culminating Projects

The field of medicine research is embroiled in a battle against aging. Particular focus is on the extension of lifespan and health-span. Lifespan duration is affected by many factors, one of which is the maintenance of the intestines of the organism. Homeostasis of the intestines is controlled by the regulation of intestine cell apoptosis and intestine cell proliferation. My research explores the role of two protein subunits found in a complex which may have possible functions in the regulation of these processes. The overall complex is formed from six subunit proteins, some of which are known to assist in other …

Increasing Functional Task Performance In Adults With Low Vision, Carrie Payne, Lauren Kufer

Dissertations, Masters Theses, Capstones, and Culminating Projects

This critically appraised topic explores the functional task performance of adults with low vision utilizing tactile vision substitution systems, specifically tongue display units (TDUs). TDUs are a novel assistive device that functions to provide artificial vision to those with low vision. TDUs pixelate images captured on a camera the person wears and the images are translated via electronic stimulation on the tongue to paint a picture. Two studies that measured functional task performance utilizing a TDU with adults with low vision were explored. Examples of functional tasks measured include word recognition, object recognition, and orientation and mobility tasks. The studies …

Validation Of The Medication Box Task Assessment, Katherine Blank, Alison Chandler, Malcolm Isely, Serena Soria, Yamin Zaw

Dissertations, Masters Theses, Capstones, and Culminating Projects

There are a limited number of validated occupation-based cognitive assessments that are feasible in clinical settings. For individuals with acquired brain injury (ABI), ecologically valid cognitive assessments are needed to understand how cognition influences functional performance. This study implemented a quantitative exploratory correlational design using a battery of gold standard tabletop cognitive assessments as criterion measurements against the Medication Box Task assessment, an occupation-based cognitive assessment. Eight participants completed the test battery. The student researchers used Pearson correlations to analyze each participant’s scores on the Medication Box Task assessment and the scores on the battery of gold standard assessments. Results …

Fall Risk Reduction Using Lifestyle-Integrated Functional Exercise (Life), Kayla L. Comer, Tiffany Huang, Kelly Schmidt, Matthew W. Tong

Dissertations, Masters Theses, Capstones, and Culminating Projects

As the population and longevity of older adults’ increases, the prevalence of falls is becoming an ever-growing issue. Falls in older adults may lead to sedentary behavior, decreased independence, and lower quality of life. Evidence has shown that traditional exercise programs emphasizing strength and balance can decrease the fall risk in older adults, but may be difficult to sustain over time. Emerging evidence suggests that exercises that are integrated into daily life, as seen in the Lifestyle-integrated Functional Exercise (LiFE) program, may have a more lasting effect in reducing fall risk in older adults. This study explored the effectiveness of …

The Effects Of Therapeutic Listening On Bilateral Coordination, Avery Wilson, Mios Buccat, Amanda Grace Irao, Morgan Mousley, Michael Yra Munchua

Dissertations, Masters Theses, Capstones, and Culminating Projects

Therapeutic Listening® is an intervention increasingly used by occupational therapists despite the lack of supporting evidence in current literature. Therapeutic Listening® is a sound-based treatment developed by Sheila Frick, OTR/L, rooted in sensory integration. The purpose of this continuation study was to compare the quality of bilateral movement in typically developing children after either listening to Therapeutic Listening® Bilateral Coordination Quick Shift or listening to white noise. This study used a randomized control pretest-posttest experimental design to analyze posture, smooth and continuous movement, effort, precision, and arm/leg movements. Specific items were further analyzed after eliminating those with a strong ceiling …

Efficacy Of Therapeutic Listening® Quickshifts In Children With Sensory Processing Difficulties, Shannon Preto, Ann Malloy, Bryant Luong

Dissertations, Masters Theses, Capstones, and Culminating Projects

Few empirical studies provide evidence for the effectiveness of Therapeutic Listening - Quickshifts (TL-Q). However, anecdotally, therapists and clients report TL-Q produces consistent positive results as an intervention for children with learning and developmental problems. In this study, the researchers examined the effectiveness of TL-Q intervention for five children with sensory processing difficulties to improve participation and function in (1) self-regulation and arousal, (2) activities of daily living (ADLs), (3) social/emotional skills, and (4) sensorimotor skills. Over the course of an 8-week prospective study, the researchers conducted a pre-test, post-test, prospective case study. During the intervention period, occupational therapist with …

Sleep As An Occupation In College Students: A Mixed Method Study, Charlotte Sally, Savannah Hancock, Rhianna Wallace, Jacqueline M. Bloom

Dissertations, Masters Theses, Capstones, and Culminating Projects

Sleep is an emerging area of research and practice for occupational therapists. The purpose of this study was to identify and investigate how college students’ cognitive perceptions and beliefs about sleep affect their quality of sleep. Four college students participated in qualitative interviews investigating their sleep beliefs and attitudes. The students also completed a two-week daily sleep diary to report their sleep beliefs, attitudes, and daily living patterns. Four emerging themes were identified from the interviews: beliefs about sleep patterns related to temporal structure of sleep, stress, daytime performance associated with sleep, and conflicting beliefs about sleep. Daily sleep diaries …

Implementing Multifactorial Education Modules With Older Adults: Individualized And Interactive Fall Prevention Education, Salvador Chavez, Jocelle Flores, Rachelle Yambao

Dissertations, Masters Theses, Capstones, and Culminating Projects

Falls are a significant concern for community-dwelling older adults (OAs), with one in four OAs reporting a fall every year. Occupational therapy students collaborated with first responders of the Novato Fire District to identify gaps in fall prevention community outreach programs and found that many interventions lack an interactive or individualized approach. Based on the gap analysis and current literature, seven education modules were developed to address key risk factors including home safety hazards, polypharmacy, fear of falling, and strength and balance exercises. Thirty community-dwelling OAs participated in the education modules that were implemented at two senior community sites in …

The Duc Healthy Aging Website: Providing Online Occupation-Based Information, Haley Caruthers, Samantha Talavera, Jackeline Ulloa, Stephanie Vera

Dissertations, Masters Theses, Capstones, and Culminating Projects

Access to current, evidence-based health information is an important step to the promotion of health and wellness for all age groups, including OAs. Since the virtual world is easily accessible and is being used more frequently by OAs, an effective way to convey relevant up-to-date health information is through a website devoted to the dissemination of health promotion information tailored for OAs, including tips for integrating healthy habits into their lifestyle. Dominican University of California’s (DUC) Healthy Aging website, developed in May 2014, contains relevant and evidence-based research, including activities and local community based programs that promote healthy aging on …

Occupational Therapy In The Intensive Care Unit, Kelsie Colombini, Kristen M. Henderson, Michelle Huie, Courtney Malachowski

Dissertations, Masters Theses, Capstones, and Culminating Projects

In recent years, the number of inpatient cardiovascular surgeries has significantly increased in hospitals around America. Occupational therapists in the intensive care unit (ICU) at Mills-Peninsula Medical Center (Burlingame, California) lack a standard protocol for addressing physical, cognitive, and psychosocial factors in patients post cardiac surgery. Furthermore, individuals’ experience and clinical reasoning frequently guides interventions rather than current evidence. The American Occupational Therapy Association’s Centennial Vision encourages occupational therapists to pursue science-driven practices and provide evidence-based interventions. In response to this Vision, an evidence-based clinical pathway was developed for the occupational therapists at Mills-Peninsula Medical Center. The clinical pathway facilitates …