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The Discriminative Stimulus Properties Of Morphine And U-50,488h In A Three-Key Assay: A Mu And Kappa Opioid Discrimination In The Pigeon, Malath Makhay
Dissertations
Opiate drugs have been classified in two-choice assays according to their ability to produce generalization in animals to the prototypicix opiate, morphine, versus vehicle, or to the k opioid, U -50,488H versus vehicle injections (Picker & Dykstra, 1987). A three-choice discrimination procedure, in which subjects discriminate among morphine, U -50,488H , and vehicle injections, might afford a greater degree of precision in characterizing the subjective effects of opioids. The feasibility of such a procedure was demonstrated in the present study, in which five pigeons were trained to discriminate among injections of 5 .6 m g/kg morphinel 5 .6 m g/kg …