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Full-Text Articles in Medicine and Health Sciences
Dielectric Properties Measurements Of Brown And White Adipose Tissue In Rats From 0.5 To 10 Ghz, Dario B. Rodrigues, Paul R. Stauffer, E. Colebeck, A. Z. Hood, S. Salahi, P. F. Maccarini, E. Topsakal
Dielectric Properties Measurements Of Brown And White Adipose Tissue In Rats From 0.5 To 10 Ghz, Dario B. Rodrigues, Paul R. Stauffer, E. Colebeck, A. Z. Hood, S. Salahi, P. F. Maccarini, E. Topsakal
Department of Radiation Oncology Faculty Papers
Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity. Although imaging techniques are available to detect subsurface BAT, there are currently no viable methods for continuous acquisition of BAT energy expenditure. Microwave (MW) radiometry is an emerging technology that allows the quantification of tissue temperature variations at depths of several centimeters. Such temperature differentials may be correlated with variations in metabolic rate, thus providing a quantitative approach to monitor BAT metabolism. In order to optimize MW radiometry, numerical and experimental phantoms with accurate dielectric properties …
Bonded Cumomer Analysis Of Human Melanoma Metabolism Monitored By 13c Nmr Spectroscopy Of Perfused Tumor Cells., Alexander A Shestov, Anthony Mancuso, Seung-Cheol Lee, Lili Guo, David S Nelson, Jeffrey C Roman, Pierre-Gilles Henry, Dennis B. Leeper, Ian A Blair, Jerry D Glickson
Bonded Cumomer Analysis Of Human Melanoma Metabolism Monitored By 13c Nmr Spectroscopy Of Perfused Tumor Cells., Alexander A Shestov, Anthony Mancuso, Seung-Cheol Lee, Lili Guo, David S Nelson, Jeffrey C Roman, Pierre-Gilles Henry, Dennis B. Leeper, Ian A Blair, Jerry D Glickson
Department of Radiation Oncology Faculty Papers
A network model for the determination of tumor metabolic fluxes from (13)C NMR kinetic isotopomer data has been developed and validated with perfused human DB-1 melanoma cells carrying the BRAF V600E mutation, which promotes oxidative metabolism. The model generated in the bonded cumomer formalism describes key pathways of tumor intermediary metabolism and yields dynamic curves for positional isotopic enrichment and spin-spin multiplets. Cells attached to microcarrier beads were perfused with 26 mm [1,6-(13)C2]glucose under normoxic conditions at 37 °C and monitored by (13)C NMR spectroscopy. Excellent agreement between model-predicted and experimentally measured values of the rates of oxygen and glucose …