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Human T-Cell Leukemia Virus Type 1 And Strongyloides Stercoralis: Partners In Pathogenesis, Adam Dykie, Tharaka Wijesinghe, Arnold B Rabson, Kiran Madugula, Christian Farinas, Sydney Wilson, David Abraham, Pooja Jain

Department of Microbiology and Immunology Faculty Papers

Infection with human T-cell leukemia/lymphoma virus type 1 (HTLV-1) has been associated with various clinical syndromes including co-infection with Strongyloides stercoralis, which is an intestinal parasitic nematode and the leading cause of strongyloidiasis in humans. Interestingly, HTLV-1 endemic areas coincide with regions citing high prevalence of S. stercoralis infection, making these communities optimal for elucidating the pathogenesis of co-infection and its clinical significance. HTLV-1 co-infection with S. stercoralis has been observed for decades in a number of published patient cases and case series; however, the implications of this co-infection remain elusive. Thus far, data suggest that S. stercoralis increases …